Results 61 to 70 of about 5,652,471 (282)

Função renal de pacientes de unidade de terapia intensiva: creatinina plasmática e proteína carreadora do retinol urinário Renal function of intensive care unit patients: plasma creatinine and urinary retinol-binding protein

Revista Brasileira de Terapia Intensiva, 2008
OBJETIVOS: A avaliação precoce da disfunção renal usando marcadores usuais não supre uma indicação quer da sensitividade e da especificidade da disfunção renal de pacientes críticos.
Cristina Satoko Mizoi, Cassiane Dezoti, Maria de Fátima Fernandes Vattimo   +2 more
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Adipocyte-Specific Over-Expression of Retinol-Binding Protein 4 (RBP4) Causes Hepatic Steatosis in Mice

Hepatology, 2016
There is considerable evidence that both retinoids and retinol‐binding protein 4 (RBP4) contribute to the development of liver disease. To understand the basis for this, we generated and studied transgenic mice that express human RBP4 (hRBP4 ...
Seung-Ah Lee, Jason J. Yuen, Hong-Feng Jiang, Barbara B. Kahn, William S. Blaner   +4 more
semanticscholar   +1 more source

Bacterially Expressed Rat Retinol-binding Protein is Functional for Retinol and Transthyretin Bindings.

Journal of Nutritional Science and Vitaminology, 1996
Retinol-binding protein (RBP) was expressed in Escherichia coli using the cDNA for rat RBP, and characterized. The expressed RBP was fused to maltose-binding protein (MBP) at the N-terminal end (MBP-RBP), and MBP was enzymatically removed from the MBP-RBP with proteinase factor Xa.
YAMAMOTO, Yuji, YOSHIZAWA, Tatsuya, MANO, Hiroshi, MASUSHIGE, Shoichi, KATO, Shigeaki   +4 more
openaire   +3 more sources

Ligand Binding Induces Conformational Changes in Human Cellular Retinol-binding Protein 1 (CRBP1) Revealed by Atomic Resolution Crystal Structures*

Journal of Biological Chemistry, 2016
Important in regulating the uptake, storage, and metabolism of retinoids, cellular retinol-binding protein 1 (CRBP1) is essential for trafficking vitamin A through the cytoplasm.
J. Silvaroli, J. M. Arne, S. Chelstowska, P. Kiser, Surajit Banerjee, M. Golczak   +5 more
semanticscholar   +1 more source

Retinol-Binding Protein Interferes with Transthyretin-Mediated β‑Amyloid Aggregation Inhibition

, 2018
β-Amyloid (Aβ) aggregation is causally linked to Alzheimer’s disease. On the basis of in vitro and transgenic animal studies, transthyretin (TTR) is hypothesized to provide neuroprotection against Aβ toxicity by binding to Aβ and inhibiting its ...
Regina M. Murphy, Regina M. Murphy (1553098), Parth Mangrolia, Parth Mangrolia (5578865)   +3 more
core   +1 more source

Characteristics of retinol accumulation from serum retinol-binding protein by cultured Sertoli cells [PDF]

, 1989
The uptake of retinol was examined in cultured Sertoli cells when retinol was provided as a complex with the transport protein retinol-binding protein (RBP). Sertoli cells accumulated [3H]retinol in a time- and temperature-dependent manner. At 32 °C, the
Shingleton, Janet L, Ong, David E, Skinner, Michael K   +2 more
core   +1 more source

Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC

Advanced Science, EarlyView.
Coexisting DCIS and IDC samples are profiled using spatial transcriptomics, single‐cell RNA sequencing, and single‐cell DNA sequencing. Integrative multi‐omics analysis reveals distinct malignant epithelial and microenvironmental features between DCIS and IDC, which are further validated using Xenium and multiplex immunohistochemistry.
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang, Tao Xing, Qihuang Zhang, Ulf Schmitz, Zhiyong Ding, Nicola Crosetto, Bingqiang Liu, Qifeng Yang   +18 more
wiley   +1 more source

Subcellular localization of retinoids, retinoid-binding proteins, and acyl-CoA:retinol acyltransferase in rat liver

Journal of Lipid Research, 1987
Studies were conducted to define the subcellular localization of endogenous retinoids (vitamin A), retinoid-binding proteins, and acyl-CoA:retinol acyltransferase (ARAT) in liver and to determine whether their distributions were affected by hepatic ...
E H Harrison, W S Blaner, D S Goodman, A C Ross   +3 more
doaj   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source