Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases [PDF]
Frontiers in Physiology, 2022 The morbidity and mortality of cardiovascular diseases (CVDs) have been increasing year by year all over the world and expanding greatly to the younger population, which becomes the leading causes of death globally that threatens human life safety ...
Yanjing Ji +3 more
doaj +5 more sources
Retinol-binding protein-4 and nonalcoholic fatty liver disease [PDF]
Chinese Medical Journal, 2022 . Nonalcoholic fatty liver disease (NAFLD) is becoming increasingly common as the global economy grows and living standards improve. Timely and effective preventions and treatments for NAFLD are urgently needed.
Hangkai Huang, Chengfu Xu, Yuanyuan Ji
doaj +4 more sources
Retinol and retinol binding protein 4 levels and COVID-19: a Mendelian randomization study [PDF]
BMC Pulmonary MedicineBackground The Corona Virus Disease 2019 (COVID-19) pandemic has struck globally. Whether the related proteins of retinoic acid (RA) signaling pathway are causally associated with the risk of COVID-19 remains unestablished.
Haixia Wang +5 more
doaj +4 more sources
Elevated Serum Retinol Binding Protein 4 is Associated with the Risk of Diabetic Cardiomyopathy [PDF]
Reviews in Cardiovascular Medicine, 2022 Background: Retinol binding protein 4 (RBP4), a biomarker for insulin resistance in type 2 diabetes (DM), is increased in heart failure. This case-control study aims to determine the association between serum RBP4 levels and diabetic cardiomyopathy (DCM).
Haihua Shan +8 more
doaj +4 more sources
Retinol and Retinol Binding Protein 4 Levels and Cardiometabolic Disease Risk. [PDF]
Circ Res, 2022 Background: Despite mechanistic studies linking retinol and RBP4 (retinol binding protein 4) to the pathogenesis of cardiovascular diseases (CVD) and type 2 diabetes (T2D), epidemiological evidence is still conflicting. We investigated whether conflicting results of previous studies may be explained by differences in the ...
Schiborn C +10 more
europepmc +8 more sources
Interplay between Fatty Acid Binding Protein 4, Fetuin-A, Retinol Binding Protein 4 and Thyroid Function in Metabolic Dysregulation [PDF]
Metabolites, 2022 Signalling between the tissues integrating synthesis, transformation and utilization of energy substrates and their regulatory hormonal axes play a substantial role in the development of metabolic disorders.
Daniela Dadej +2 more
doaj +2 more sources
RPB4 and pathogenesis of diabetes [PDF]
The Journal of Clinical Endocrinology & Metabolism, 2007 Obesity is an important risk factor for a number of chronic diseases that impose a huge burden on individuals and society. Recently it has become clear that adipose tissue-secreted products may play a significant role in mediating many obesity-related ...
Kumar, Sudhesh +1 more
core +3 more sources
Identification and Characterization of a Non-retinoid Ligand for Retinol-binding Protein 4 Which Lowers Serum Retinol-binding Protein 4 Levels in Vivo [PDF]
Journal of Biological Chemistry, 2009 Retinol-binding protein 4 (RBP4) transports retinol from the liver to extrahepatic tissues, and RBP4 lowering is reported to improve insulin sensitivity in mice. We have identified A1120, a high affinity (K(i) = 8.3 nm) non-retinoid ligand for RBP4, which disrupts the interaction between RBP4 and its binding partner transthyretin.
Alykhan Motani +16 more
openalex +4 more sources
The Clinical Significance of Urinary Retinol-Binding Protein 4: A Review. [PDF]
Int J Environ Res Public Health, 2022 Effective biomarkers for early diagnosis, prognostication, and monitoring in renal diseases (in general) comprise an unmet need. Urinary retinol-binding protein 4, which is the most sensitive indicator of renal tubular damage, holds great promise as a universal biomarker for renal pathologies, in which tubular injury is the driving force.
Ratajczyk K +8 more
europepmc +4 more sources
Serum retinol-binding protein 4 levels in polycystic ovary syndrome [PDF]
Endocrine Connections, 2019 Objective: Serum levels of retinol-binding protein 4 (RBP4), an adipokine thought to affect systemic insulin sensitivity, were compared between women with polycystic ovary syndrome (PCOS) and non-PCOS controls to evaluate the association of RBP4 with ...
Shilpa Lingaiah +5 more
doaj +6 more sources