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Retinol-binding protein 4, insulin resistance and pregnancy

Metabolism, 2012
Sir, the recent publication on retinol-binding protein 4 (RBP4), insulin resistance (IR) and pregnancy is very interesting [1]. Khovidhunkit et al concluded, “Serum RBP4 levels in pregnancy are not associated with IR.” [1]. This report is very interesting but is discordant with previous reports. RBP4 is discussed in terms of its clinical correlation to
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Effects of retinol binding protein-4 on vascular endothelial cells

Biochemical and Biophysical Research Communications, 2011
The study was designed to investigate the effect of retinol binding protein (RBP)-4 on the phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) pathways, which mediate the effects of insulin in vascular endothelial cells. The effects of RBP4 on nitric oxide (NO) and insulin-stimulated endothelin-1 (ET-1) secretion and on ...
Kohzo, Takebayashi, Ryouichi, Sohma, Yoshimasa, Aso, Toshihiko, Inukai   +3 more
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Retinol-Binding Protein 4 and Insulin Resistance

New England Journal of Medicine, 2006
To the Editor: Graham et al. (June 15 issue)1 report that serum levels of retinol-binding protein 4 (RBP4) correlated with the magnitude of insulin resistance in various subjects. However, RBP4 and plasma insulin levels were dissociated in subjects who did not have an improvement in insulin sensitivity after exercise.1 Thus, we believe that the ...
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Retinol-Binding Protein 4 in Patients with Gestational Diabetes Mellitus

Journal of Women's Health, 2010
It is still unknown if serum retinol-binding protein 4 (RBP4) relates to metabolic control and the occurrence of gestational diabetes mellitus (GDM). We studied RBP4 levels in patients with insulin-treated GDM and healthy pregnant women twice during pregnancy.Sixty-three women with GDM and 38 healthy pregnant women were included. Serum RBP4 levels were
Katharina, Klein, Dagmar, Bancher-Todesca, Heinz, Leipold, Martin, Knöfler, Peter, Haslinger, Ammon, Handisurya, Alexandra, Kautzky-Willer, Christof, Worda   +7 more
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Retinol-binding protein 4, fetal overgrowth and fetal growth factors

Pediatric Research, 2019
Retinol-binding protein 4 (RBP-4) is an adipokine involved in regulating insulin sensitivity which would affect fetal growth. It is unclear whether RBP-4 is associated with fetal overgrowth, and unexplored which fetal growth factor(s) may mediate the association.In the Shanghai Birth Cohort, we studied 125 pairs of larger-for-gestational-age (LGA ...
Meng-Nan, Yang, Guang-Hui, Zhang, Kun, Du, Wen-Juan, Wang, Yu, Dong, Hua, He, Huei-Chen, Chiu, Yu-Na, Guo, Fengxiu, Ouyang, Jun, Zhang, Xiao-Lin, Hua, Zhong-Cheng, Luo   +11 more
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Retinol-binding protein-4 in experimental and clinical metabolic disease

Expert Review of Molecular Diagnostics, 2008
Retinol-binding protein-4 (RBP4), a 21-kDa protein synthesized in the liver and adipose tissue, has recently been described as a murine adipokine involved in the development of insulin resistance. The expression of the gene encoding RBP4 was increased in the adipose tissue, but not in the liver, of insulin-resistant adipose GLUT4(-/-) mice and five ...
Maximilian, von Eynatten, Per M, Humpert
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Application of an allosteric model to describe the interactions among retinol binding protein 4, transthyretin, and small molecule retinol binding protein 4 ligands

Analytical Biochemistry, 2009
Retinol binding protein 4 (RBP4) is a serum protein that serves as the major transport protein for retinol (vitamin A). Recent reports suggest that elevated levels of RBP4 are associated with insulin resistance and that insulin sensitivity may be improved by reducing serum RBP4 levels. This can be accomplished by administration of small molecules, such
Peter, Coward, Marion, Conn, Jie, Tang, Fei, Xiong, Anthony, Menjares, Jeff D, Reagan   +5 more
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Retinol binding protein 4 and its membrane receptors: a metabolic perspective

Hormone Molecular Biology and Clinical Investigation, 2015
Abstract Nearly a decade of intense research has passed since the first report linking circulating retinol binding protein 4 (RBP4) to the development of insulin resistance. By now, a variety of underlying mechanisms have been identified; some of them are adherent to the canonical role of this circulating protein, which is to transport ...
Ronja, Fedders, Matthias, Muenzner, Michael, Schupp   +2 more
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Circulating retinol-binding protein 4 and metabolic syndrome in the elderly

Wiener Medizinische Wochenschrift, 2011
Retinol-binding protein (RBP) 4, a human adipokine that specifically binds to retinol, has been reported to provide a link between obesity and insulin resistance. Plasma RBP4 concentration may be under the influence of age and obesity, but only a few studies has investigated this link in elderly individuals.
Nazanin, Mostafaie, Christian, Sebesta, Sonja, Zehetmayer, Susanne, Jungwirth, Klaus R, Huber, Margareta, Hinterberger, Thomas, Leitha, Jörg, Hofman, Milos, Hejtman, Karl, Schrattbauer, Walter, Krugluger, Karl-Heinz, Tragl, Peter, Fischer   +12 more
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Retinol Binding Protein 4: Role in Diabetes and Cancer

2016
Vitamin A, retinol, circulates in blood associated with retinol-binding protein 4 (RBP4). It was reported that the level of circulating RBP4 is often elevated in obese mice and humans and that, under these circumstances, the protein induces insulin resistance.
Daniel C. Berry, Noa Noy
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