Beyond a gatekeeper: the non-classical signaling role of STRA6 in driving endothelial senescence and atherosclerosis [PDF]
Frontiers in ImmunologyEndothelial cell (EC) senescence is a fundamental driver of atherosclerosis. This review posits that the primary pathogenic role of Stimulated by Retinoic Acid 6 (STRA6) in the endothelium is not its canonical vitamin A transport but its non-classical ...
Yong Yuan +7 more
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Severe dengue in children associates with dysregulation of lipid homeostasis, complement cascade and retinol transport [PDF]
Clinical and Translational Medicine, 2023 Aleksha Panwar +11 more
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BiomedicinesBackground: The protein that binds to retinol 4 (RBP4), is a lipocalin-family protein, secreted primarily by the adipose tissue and the liver, and has also been reported to be produced by other tissues, including the kidney.
María Paz Nieto-Bona +2 more
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The Potential Role of Retinol-Binding Protein 4 in Heart Failure: A Review [PDF]
Reviews in Cardiovascular MedicineHeart failure (HF) is a heterogeneous clinical syndrome, the prevalence of which is increasing among younger adults, promoting global concern due to its significant morbidity and mortality.
Jiayi Liu, Yaping Wang
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Biological Functions of RBP4 and Its Relevance for Human Diseases
Frontiers in Physiology, 2021 Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.
Julia S. Steinhoff +3 more
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The transport of retinol in human plasma [PDF]
FEBS Letters, 1969 Evidence in support of the view that tryptophanrich prealbumin [l] may serve as the specific transport protein for retinol in human plasma has previously been reported by Alvsaker, Haugli and Laland [2]. Since thyroxine is transported partly by this protein [3] , thyroxine and retinol would then share the same transport protein. In order to investigate
Johannessen, S. +2 more
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An in vitro model for vitamin A transport across the human blood–brain barrier
eLife, 2023 Vitamin A, supplied by the diet, is critical for brain health, but little is known about its delivery across the blood–brain barrier (BBB). Brain microvascular endothelial-like cells (BMECs) differentiated from human-derived induced pluripotent stem ...
Chandler B Est, Regina M Murphy
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Identification of Transthyretin Tetramer Kinetic Stabilizers That Are Capable of Inhibiting the Retinol-Dependent Retinol Binding Protein 4-Transthyretin Interaction [PDF]
, 2021 Dissociation of transthyretin (TTR) tetramers may lead to misfolding and aggregation of pro-amyloidogenic monomers, which underlies TTR amyloidosis (ATTR) pathophysiology.
Arun, Raja +7 more
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Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis
Molecular Metabolism, 2020 Objective: Transformation of white into brown fat (“browning”) reduces obesity in many preclinical models and holds great promise as a therapeutic concept in metabolic disease. Vitamin A metabolites (retinoids) have been linked to thermogenic programming
Anna Fenzl +11 more
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Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source