Results 31 to 40 of about 2,128,430 (249)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Mapping of the extracellular RBP4 ligand binding domain on the RBPR2 receptor for Vitamin A transport

Frontiers in Cell and Developmental Biology, 2023
The distribution of dietary vitamin A/all-trans retinol/ROL throughout the body is critical for maintaining retinoid function in peripheral tissues and for retinoid delivery to the eye in the support of visual function.
Rakesh Radhakrishnan, Matthias Leung, Ashish K. Solanki, Glenn P. Lobo, Glenn P. Lobo, Glenn P. Lobo   +5 more
doaj   +1 more source

CD8+ T cell memory is sustained in mice by hepatic stellate cells

Hepatology, EarlyView., 2022
HSC role in memory CD8+ T cell maintenance. Abstract Background and Aims Long‐lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8+ cytotoxic T cells (MemCD8TCs) is thought to be mediated by IL‐15/IL‐15R heterodimer (15HD)‐expressing myeloid cells.
Yi‐Ting Chen, Yu‐Chia Su, Yee‐Ern Or, Chin‐Fu Cheng, John T. Kung   +4 more
wiley   +1 more source

Proxy markers of serum retinol concentration, used alone and in combination, to assess population vitamin A status in Kenyan children: a cross-sectional study [PDF]

, 2015
Background Serum retinol concentration determined by high-performance liquid chromatography (HPLC) is recommended by the World Health Organization to assess population vitamin A status.
Inge D Brouwer, Verhoef, H., Elise F Talsma, Alida Melse-Boonstra, Brouwer, Inge D, Hulshof, Paul JM, Talsma, E.F., Anne S Mburu-de Wagt, Paul JM Hulshof, Hans Verhoef, Talsma, Elise F, Mburu-de Wagt, Anne S, Melse-Boonstra, Alida, Brouwer, I.D., Hulshof, P.J.M., Mburu-de Wagt, A.S., Verhoef, Hans, Boonstra, A., Talsma, E.F.; Verhoef, H.; Brouwer, I.D.; Mburu-de Wagt, A.S.; Hulshof, P.J.M.; Melse-Boonstra, A.   +18 more
core   +2 more sources

A multicompartmental model of vitamin A kinetics in rats with marginal liver vitamin A stores.

Journal of Lipid Research, 1985
A linear, first-order, constant-coefficient multicompartmental model is presented which describes the dynamics of [3H]retinol turnover in adult rats with normal plasma retinol concentrations but low liver stores (less than 100 micrograms of retinol ...
M H Green, L Uhl, J B Green
doaj   +1 more source

Confocal Raman imaging reveals the impact of retinoids on human breast cancer via monitoring the redox status of cytochrome c

Scientific Reports, 2023
This paper expands the current state of knowledge on impact of retinoids on redox status of cytochrome c in cancers. Little is known how the expression of cytochromes may influence the development of cancers.
Jakub Maciej Surmacki, Halina Abramczyk
doaj   +1 more source

A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish

Cells, 2020
Dietary vitamin A/all-trans retinol/ROL plays a critical role in human vision. ROL circulates bound to the plasma retinol-binding protein (RBP4) as RBP4-ROL. In the eye, the STRA6 membrane receptor binds to circulatory RBP4 and internalizes ROL. STRA6 is,
Ashish K. Solanki, Altaf A. Kondkar, Joseph Fogerty, Yanhui Su, Seok-Hyung Kim, Joshua H. Lipschutz, Deepak Nihalani, Brian D. Perkins, Glenn P. Lobo   +8 more
doaj   +1 more source

Evidence for an Essential Role of Megalin in Transepithelial Transport of Retinol [PDF]

Journal of the American Society of Nephrology, 1999
Abstract. Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By immunocytochemistry of human, rat, and mouse renal proximal tubules, a strong staining in apical endocytic vacuoles, lysosomes, endoplasmic reticulum, Golgi, and basal ...
Christensen, Erik Ilsø, Moskaug, J.Ø., Vorum, Henrik, Jacobsen, Christian, Gundersen, T.E., Nykjær, Anders; id_orcid 0000-0001-6422-6736, Blomhoff, R., Willnow, T.E., Moestrup, Søren Kragh   +8 more
openaire   +3 more sources

Retinol Esterification Activity Contributes to Retinol Transport in Stellate Cells.

Cell Structure and Function, 1999
The mechanisms of retinol transport and accumulation in hepatic stellate cells (HSC) remain to be elucidated. Our previous studies suggested that retinol esterification activity, particularly lecithin:retinol acyltransferase (LRAT) activity, in liver retinoid metabolism is important to elucidate the relationship between retinol uptake by HSC and the ...
T, Matsuura, S, Hasumura, S, Nagamori, K, Murakami   +3 more
openaire   +3 more sources