Results 91 to 100 of about 201,939 (281)

Mass spectrometry in ocular drug research

open access: yesMass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo   +6 more
wiley   +1 more source

Involving the parents of preterm babies

open access: yesCommunity Eye Health Journal, 2017
The prevention, detection and treatment of ROP is a team responsibility. Parents are important members of the team and their involvement is essential in ensuring optimal visual outcomes.
Julie Flanagan   +2 more
doaj  

Deficits in trabecular bone microarchitecture in young women with Type 1 diabetes mellitus [PDF]

open access: yes, 2015
Context: The pathophysiological mechanism of increased fractures in young adults with Type 1 Diabetes Mellitus (T1DM) is unclear. Objective: Case:control study of trabecular bone microarchitecture and vertebral marrow adiposity in young women with ...
Al-Daghri   +49 more
core   +1 more source

Glucose‐Responsive PAGR1‐Regulated Skeletal Muscle Gene Program Controls Systemic Glucose Homeostasis and Hepatic Metabolism

open access: yesAdvanced Science, EarlyView.
The study reveals that PAXIP1‐associated glutamate‐rich protein 1 (PAGR1), a glucose‐responsive regulator in skeletal muscle, modulates systemic glucose homeostasis and hepatic metabolism. Muscle‐specific PAGR1 deletion enhances insulin signaling, promotes glucose transporter 4 (GLUT4) translocation, and protects against high‐fat‐diet‐induced insulin ...
Chenyun Ding   +19 more
wiley   +1 more source

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

open access: yesAdvanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong   +9 more
wiley   +1 more source

Refractive Index‐Corrected Light‐Sheet Microscopy for Macro‐View Cardiovascular Imaging

open access: yesAdvanced Science, EarlyView.
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Enbo Zhu   +13 more
wiley   +1 more source

Macrophage Derived Galectin‐3 Promotes Renal Fibrosis and Diabetic Kidney Disease by Enhancing TGFβ1 Signaling

open access: yesAdvanced Science, EarlyView.
Macrophage‐derived Galectin‐3 amplifies TGFβ1 signaling to drive diabetic kidney fibrosis: a novel therapeutic target. Abstract Over 30% of patients with type 2 diabetes develop diabetic kidney disease (DKD), which has emerged as a major contributor to end stage renal disease.
Yibing Chen   +17 more
wiley   +1 more source

Magnetically Controllable and Degradable Milliscale Swimmers as Intraocular Drug Implants

open access: yesAdvanced Science, EarlyView.
Magnetically controllable degradable milliscale swimmers (MDMS) offer a promising alternative to commercial intraocular drug implants, reducing complications like implant dislocation and uncontrolled drug release. MDMS achieve high velocities in ocular environments, enable real‐time imaging, and deliver drugs effectively without disrupting retinal ...
Erdost Yildiz   +8 more
wiley   +1 more source

Enhanced Multitask Learning with Attention Sparse Routing Mechanism for Intelligent Diabetes Prediction

open access: yesAdvanced Intelligent Systems, EarlyView.
The model leverages patient time‐space information for pattern feature representations. Encoders extract first and second‐order features, aggregated with categorical embeddings and dense features. Task‐specific and shared experts use gated networks, with a dispatch layer routing information for diabetes risk evaluation and blood glucose prediction ...
Yingshuai Wang   +8 more
wiley   +1 more source

Takayasu Arteritis Presenting as Bilateral Ocular Ischemic Syndrome

open access: yesVascular Specialist International, 2020
A 26-year-old female came in with progressive blurring of vision. She had developed memory loss and complained of headache, significant weight loss, and exertional left calf pain after prolonged walking.
Ramon B. Larrazabal   +2 more
doaj   +1 more source

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