NETs‐CD44‐IL‐17A Feedback Loop Drives Th17‐Mediated Inflammation in Behçet's Uveitis
Advanced Science, EarlyView.In experimental autoimmune uveitis (EAU), neutrophils interact with T helper 17 (Th17) cells through neutrophil extracellular traps (NETs) to exert a pro‐inflammatory effect. In vitro and in vivo experiments identify that NETs promote IL‐17A secretion in Th17 cells via CD44, and increasing IL‐17A further induces more NETs formation.
Yi Wu +11 more
wiley +1 more source
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Detection of Diabetic Anomalies in Retinal Images using Morphological Cascading Decision Tree [PDF]
arXiv, 2020 This research aims to develop an efficient system for screening of diabetic retinopathy. Diabetic retinopathy is the major cause of blindness. Severity of diabetic retinopathy is recognized by some features, such as blood vessel area, exudates, haemorrhages and microaneurysms.
arxiv
Grading diabetic retinopathy (DR) using the Scottish grading protocol
Community Eye Health Journal, 2016 Although traditionally the features of DR have been identified through direct ophthalmoscopy or slit lamp biomicroscopy, digital photography is more sensitive than direct ophthalmoscopy and is comparable to slit lamp examination by a trained observer.
Sonia Zachariah +2 more
doaj
Classification of pathology in diabetic eye disease [PDF]
, 2005 Proliferative diabetic retinopathy is a complication of diabetes that can eventually lead to blindness. Early identification of this complication reduces the risk of blindness by initiating timely treatment.
Cesar, R.M., Jr. +3 more
core
Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]
, 2016 Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W +5 more
core +2 more sources
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, EarlyView.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
Correlation between global statistics and Romanian prevalence of rethinopathy of prematurithy (ROP) [PDF]
Romanian Journal of Medical Practice, 2016 The active discovery of risk factors among pregnant women could lead to a decrease în premature births in Romania which are currently above the European average – 9% over 6.5%.
Daniela POPESCU, Dumitru MATEI
doaj +1 more source
Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat. [PDF]
, 2019 Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics
Blodi, Barbara A +10 more
core
Optimizing Measurement of Vascular Endothelial Growth Factor in Small Blood Samples of Premature Infants [PDF]
, 2019 To establish a method that allows for the reliable assessment of vascular endothelial growth factor (VEGF-A) concentrations in very small blood samples of preterm infants. Systemic VEGF measurements are important in view of the most appropriate Anti-VEGF
Lopez Yomayuza, Claudia C. +3 more
core +1 more source