Results 71 to 80 of about 6,502 (203)

A hybrid coloboma and optic disc pit associated with macular retinoschisis

BMC Ophthalmology, 2019
Background To report and describe an unusual case of a patient with optic disc pit in one eye and optic disc coloboma with a focal pit associated with macular retinoschisis in the other eye. Case presentation A 21-year-old woman presented with optic disc
Ricardo Yuji Abe, Camila Ishii Iguma, Lorena Campos Wen   +2 more
doaj   +1 more source

AAV Gene Therapy Drug Development and Translation of Engineered Ocular and Neurotropic Capsids: A Systematic Review Using Natural Language Processing

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Natural AAV serotypes often lack specificity and efficiency, leading to off‐target effects and a low therapeutic index. To overcome these limitations of naturally occurring serotypes, there has been a keen interest in the field to engineer novel capsids to enhance tissue and cell‐specific targeting, resulting in a high number of published ...
Chinaza Agbim, Heng‐Yi Wu, Chloe Kim, Elizabeth Mutter‐Rottmayer, Shraddha Sadekar, Milica Markovic   +5 more
wiley   +1 more source

Expression Profiling Analysis Reveals Key MicroRNA– mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa [PDF]

, 2018
PURPOSE. The aim of this study was to identify differentially expressed microRNAs (miRNAs) that might play an important role in the etiology of retinal degeneration in a genetic mouse model of retinitis pigmentosa (rd10 mice) at initial stages of the ...
Anasagasti, Ander, Barandika, Olatz, Caffarel, María M., Ezquerra-Inchausti, Maitane, López de Munain Arregui, Adolfo José, Muñoz-Culla, Maider, Otaegui Bichot, David, Ruiz-Ederra, Javier   +7 more
core   +2 more sources

A fast protocol for photodynamic therapy in exudative choroidal circumscribed hemangioma: Early laser irradiance after end of verteporfin infusion

Acta Ophthalmologica, Volume 103, Issue 7, Page 831-841, November 2025.
Abstract Purpose The aim of the study is to compare the risk of first‐line photodynamic therapy (PDT) failure according to the PDT protocol performed in patients with exudative choroidal circumscribed hemangioma (CCH). Methods We retrospectively included patients from 11 European centres in France, Italy and Denmark.
Paul Dubar, Thibaud Mathis, Emilie Hucteau, Juliette Thariat, Maxime Nhari, Célia Maschi, Carsten Faber, Jens Folke Kiilgaard, Carlo Mosci, Catherine Favard, Sarah Tick, Anh‐Minh Nguyen, Jean‐Pierre Caujolle, Marie‐Noëlle Delyfer, Laurence Rosier   +14 more
wiley   +1 more source

Distinguishing features of microvascular abnormalities in high myopia retinoschisis via multimodal imaging

Photodiagnosis and Photodynamic Therapy
Purpose: To report the differences between microvascular abnormalities (MVAs) and retinal vasculitis in patients with high myopia (HM) and retinoschisis and discuss the efficacy of treatments, including corticosteroids, and posterior vitreous detachment (
Yunhan Tao, Xuhui Chen, Tao Li, Xian Zhang, Xufang Sun   +4 more
doaj   +1 more source

Retinal Viral Gene Therapy: Impact of Route of Administration on Serious Adverse Events—A Systematic Review

Clinical &Experimental Ophthalmology, Volume 53, Issue 8, Page 967-985, November 2025.
ABSTRACT Background To explore the prevalence of serious adverse events (SAEs) associated with retinal viral gene therapy and to examine trends influencing SAE occurrences in human gene therapy surgeries and pre‐clinical animal trials. Methods Literature review was performed to identify peer‐reviewed human and animal studies relevant to viral gene ...
Aubrey Berger, Ciera D. Johnson, Alan D. Marmorstein, Brittni A. Scruggs   +3 more
wiley   +1 more source

Stellate Nonhereditary Idiopathic Foveomacular Retinoschisis: Cataract Surgery

Case Reports in Ophthalmological Medicine, 2022
Purpose. We present the first case described in the literature of cataract surgery in a patient with stellate nonhereditary idiopathic foveomacular retinoschisis (SNIF). Methods. In this case report, we describe the extensive workup we did on our patient,
Sofie Van der Auwera, Oscar Kallay
doaj   +1 more source

Cellular Imaging Of The Tapetal-like Reflex In Carriers Of RPGR-associated Retinopathy [PDF]

, 2017
PURPOSE: To examine the features of the tapetal-like reflex (TLR) in female carriers of RPGR-associated retinopathy by means of adaptive optics scanning light ophthalmoscopy (AOSLO) and spectral domain optical coherence tomography.
Carroll, J, Dubra, A, Kalitzeos, A, Kasilian, M, Langlo, C, Michaelides, M, Samra, R, Strampe, M, Tee, JJL, Webster, AR   +9 more
core   +1 more source

Decoding the Genetic Puzzle of Inherited Retinal Dystrophies: Novel Insights From a Turkish Cohort

Clinical Genetics, Volume 108, Issue 5, Page 532-552, November 2025.
This study analyzes 94 IRD patients from a Turkish cohort using a 141‐gene NGS panel, achieving a 74% diagnostic yield. The identification of 28 novel variants highlights the genetic diversity of IRDs in Türkiye and underscores the value of population‐specific molecular testing.
Şenol Demir, Esra Arslan Ateş, Orkun Sevik, Bengisu Sözer, Tuğba Köse, Özlem Şahin, Ahmet Arman, Bilgen Bilge Geçkinli   +7 more
wiley   +1 more source

Exploring AAV‐Mediated Gene Therapy for Inner Ear Diseases: from Preclinical Success to Clinical Potential

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu, Wuhui He, Yun Xiao, Qiong Wu, Qing Zhang, Tiesong Zhang, Lei Xu, Xinyi Pang   +7 more
wiley   +1 more source