An HPLC-MS/MS method for the separation of α-retinyl esters from retinyl esters. [PDF]
J Chromatogr B Analyt Technol Biomed Life Sci, 2016 Enzymatic cleavage of the nonsymmetric provitamin A carotenoid α-carotene results in one molecule of retinal (vitamin A), and one molecule of α-retinal, a biologically inactive analog of true vitamin A. Due to structural similarities, α-retinyl esters and vitamin A esters typically coelute, resulting in the overestimation of vitamin A originating from ...
Goetz HJ +6 more
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Journal of Lipid Research, 1995 Previous studies have indicated the presence of both neutral and acid, bile salt-independent retinyl ester hydrolases associated with plasma membrane and endosome fractions of rat liver homogenates. In the present studies, chylomicrons containing tritium-
E H Harrison, M Z Gad, A C Ross
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Retinyl esters are hydrolyzed in early endosomes of J774 macrophages
Journal of Lipid Research, 1999 The aim of the current study was to identify the subcellular compartment(s) responsible for the hydrolysis of chylomicron remnant-retinyl esters, in J774.1 cells.
E. Hagen +4 more
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Isolation and Characterization of a Microsomal Acid Retinyl Ester Hydrolase [PDF]
Journal of Biological Chemistry, 2005 Previous work demonstrated both acid and neutral, bile salt-independent retinyl ester hydrolase activities in rat liver homogenates. Here we present the purification, identification, and characterization of an acid retinyl ester hydrolase activity from solubilized rat liver microsomes.
Thomas Linke +2 more
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Cultured Müller cells from mammals can synthesize and accumulate retinyl esters. [PDF]
Exp Eye Res, 2012 Betts BS, Obregon I, Tsin AT.
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Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CCl<sub>4</sub>-Induced Liver Injury. [PDF]
Liver IntABSTRACT Background and Aims Advanced liver disease leads to liver fibrosis that is characterised by the activation of non‐parenchymal stellate cells, accumulation of extracellular matrix proteins, and the loss of hepatic vitamin A stores. To date, the molecular mechanisms and enzymes mediating the loss of hepatic vitamin A stores are incompletely ...
Wagner C +11 more
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Vitamin A Supplementation Increases the Uptake of Chylomicron Retinyl Esters into the Brain of Neonatal Rats Raised under Vitamin A-Marginal Conditions. [PDF]
J Nutr, 2016 Hodges JK, Tan L, Green MH, Ross AC.
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Dietary Vitamin A Impacts Refractory Telogen
Frontiers in Cell and Developmental Biology, 2021 Hair follicles cycle through periods of growth (anagen), regression (catagen), rest (telogen), and release (exogen). Telogen is further divided into refractory and competent telogen based on expression of bone morphogenetic protein 4 (BMP4) and wingless ...
Liye Suo +6 more
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Retinol metabolism in the mollusk Osilinus lineatus indicates an ancient origin for retinyl ester storage capacity. [PDF]
PLoS ONE, 2012 Although retinoids have been reported to be present and active in vertebrates and invertebrates, the presence of mechanisms for retinoid storage in the form of retinyl esters, a key feature to maintain whole-organism retinoid homeostasis, have been ...
Manuel Gesto +3 more
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Hepatic Retinyl Ester Hydrolases and the Mobilization of Retinyl Ester Stores [PDF]
Nutrients, 2016 For mammals, vitamin A (retinol and metabolites) is an essential micronutrient that is required for the maintenance of life. Mammals cannot synthesize vitamin A but have to obtain it from their diet. Resorbed dietary vitamin A is stored in large quantities in the form of retinyl esters (REs) in cytosolic lipid droplets of cells to ensure a constant ...
Lukas Grumet +2 more
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