Results 181 to 190 of about 16,728 (252)

Hyper-RAG: combating LLM hallucinations using hypergraph-driven retrieval-augmented generation. [PDF]

Nat Commun
Feng Y, Hu H, Ying S, Hou X, Liu S, Yang M, Li J, Du S, Zheng N, Hu H, Gao Y.   +10 more
europepmc   +1 more source

Ammonification Process Is Limited by Transformation of Medium Molecular Weight Nitrogenous Organics but Not Hydrolysis of Proteins

Advanced Science, EarlyView.
A multi‐level analytical framework, integrating protein‐level persistence analysis, nontargeted HRMS formula tracking, peptide‐level proteomics, and targeted monomer quantification under varying redox conditions, together with FMO calculations reveal that ammonification is limited by medium molecular weight nitrogenous multimers.
Jing Li, Junjie Qiu, Fan Lü, Hua Zhang, Pinjing He   +4 more
wiley   +1 more source

A graph retrieval-augmented generation pipeline for systematic drug target discovery: validation and application to ocular neovascularization. [PDF]

Brief Bioinform
Mun Y, Ma DJ, Kim HK, Joo K, Park SJ, Woo SJ, Park KH.   +6 more
europepmc   +1 more source

Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution

Advanced Science, EarlyView.
MCKcat, a deep learning framework combining multi‐scale convolution and cross‐attention, accurately predicts enzyme turnover number (kcat) by fusing sequence and reaction representations. It couples with rational design in a two‐step strategy for Bacillus aryabhattai laccase engineering, achieving a 75% positive rate with synergistically enhanced ...
Fengya Ge, Xiangyang Ma, Jiyan Li, Mengxiang Wang, Fuping Lu, Yihan Liu, Lin Wang   +6 more
wiley   +1 more source

MuseRAG++: a deep retrieval-augmented generation framework for semantic interaction and multi-modal reasoning in virtual museums. [PDF]

Sci Rep
Hu Y.
europepmc   +1 more source

SAT1‐Induced Spermidine Depletion Potentiates Food Allergy

Advanced Science, EarlyView.
Spermidine depletion, driven by upregulated spermidine/spermine N1‐acetyltransferase (SAT1), potentiates food allergy by promoting mast cell degranulation through autophagy suppression. SAT1 physically interacts with the long noncoding RNA Cdk19os to inhibit Atg5 and Atg7, disrupting autophagic flux.
Manman Liu, Beiyu Zhang, Junjuan Wang, Yue Jiang, Shiwen Han, Qianwei Wang, Lingyu Zeng, Jinfeng Wang, Huilian Che   +8 more
wiley   +1 more source

Automated candidate confounder scoping for adjustment in clinical research: a retrieval-augmented generation approach. [PDF]

BioData Min
Li J, Wu K, Wang X, Tao R, Ma Y, Lv H, Zhao X, Lan Y, Li L, Wang L.   +9 more
europepmc   +1 more source

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Retrieval-Augmented Generation-Enabled Multimodal Large Language Model for Histopathologic Grading of Cutaneous Squamous Cell Carcinoma and Melanocytic Nevi. [PDF]

Cancers (Basel)
Mijares J, Gan E, Jairath NK, Hamad J, Alomari A, Ramachandran V, Que SKT.   +6 more
europepmc   +1 more source