Results 71 to 80 of about 1,062,230 (224)
, 2001 We have developed systems of two types for NTCIR2. One is an enhenced version of the system we developed for NTCIR1 and IREX. It submitted retrieval results for JJ and CC tasks. A variety of parameters were tried with the system.
Isahara, Hitoshi +4 more
core +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
IEEE AccessThis paper introduces an innovative content-based image retrieval system for precise and effective retrieval of satellite images. The system integrates liquid autoencoders with shearlet transforms to derive robust feature representations from satellite ...
Sai Bhargav Kasetty, K. Rajakumar
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Dublin City University at CLEF 2004: experiments with the ImageCLEF St Andrew's collection [PDF]
, 2004 For the CLEF 2004 ImageCLEF St Andrew's Collection task the Dublin City University group carried out three sets of experiments: standard cross-language information retrieval (CLIR) runs using topic translation via machine translation (MT), combination ...
Groves, Declan +5 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Evaluation Criteria of Information Retrieval Systems: What We Know and What We Do Not Know
Iranian Journal of Information Processing & Management, 2014 Evaluation of information retrieval systems is one of the greatest challenges for information science specialists, because determining the performance of a system depends on judgment of the relevance of documents provided by the system to the user's ...
Nadjla Hariri +3 more
doaj
Efficient AUC Optimization for Information Ranking Applications
, 2016 Adequate evaluation of an information retrieval system to estimate future performance is a crucial task. Area under the ROC curve (AUC) is widely used to evaluate the generalization of a retrieval system. However, the objective function optimized in many
C Cortes +6 more
core +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source