Results 191 to 200 of about 49,871 (252)

Inhibition of late sodium current prevents pathological hyperactivation of calcium/calmodulin‐dependent protein kinase IIδ in a murine model of acute doxorubicin‐related cardiotoxicity

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Doxorubicin (DOX) is a highly effective anthracycline, whose clinical application for cancer is limited by cardiotoxicity. The mechanisms underlying doxorubicin‐induced toxic cardiomyopathy (DICM) involve electrophysiological remodelling with intracellular Na+ overload because of increased late INa and hyperactivation of
Anna‐Lena Feder, Anna‐Maria Pfützenreuter, Lea Maria Funke, Maria Johanna Baier, Daniel Tarnowski, Laura Stengel, Lars Siegfried Maier, Can Martin Sag   +7 more
wiley   +1 more source

Alternaria TeA toxin activates a chloroplast retrograde signaling pathway to facilitate JA-dependent pathogenicity. [PDF]

Plant Commun
Shi J, Wang H, Li M, Mi L, Gao Y, Qiang S, Zhang Y, Chen D, Dai X, Ma H, Lu H, Kim C, Chen S.   +12 more
europepmc   +1 more source

Alcohol-induced CYP2E1, mitochondrial dynamics and retrograde signaling in human hepatic 3D organoids. [PDF]

Free Radic Biol Med, 2020
Angireddy R, Chowdhury AR, Zielonka J, Ruthel G, Kalyanaraman B, Avadhani NG.   +5 more
europepmc   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, EarlyView.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source

Modulation of early gene expression responses to water deprivation stress by the E3 ubiquitin ligase ATL80: implications for retrograde signaling interplay. [PDF]

BMC Plant Biol
Méndez-Gómez M, Sierra-Cacho D, Jiménez-Morales E, Guzmán P.   +3 more
europepmc   +1 more source

Bile‐Derived Exosomal miR‐196a/‐196b as Diagnostic Biomarkers Associated With Tumor Progression in Biliary Tract Cancer

Cancer Science, EarlyView.
Bile‐derived exosomal miR‐196a and miR‐196b are identified as novel biomarkers for biliary tract cancer. Serum miR‐196a levels are significantly elevated in advanced disease with metastasis, while both miRNAs contribute to tumor progression by promoting cancer cell proliferation and invasion.
Naotaka Kugiyama, Katsuya Nagaoka, Takehisa Watanabe, Michihiro Yoshida, Tadashi Toyohara, Cheng Pan, Kenyu Hashimoto, Fumiya Otsuka, Shinya Ushijima, Yukiko Uramoto, Hajime Iwasaki, Motohiro Yoshinari, Shunpei Hashigo, Kazuki Hayashi, Itaru Naitoh, Fumihiro Okumura, Hiromu Kondo, Kaiki Anbe, Hiromitsu Hayashi, Yoshihiro Komohara, Yasuhito Tanaka   +20 more
wiley   +1 more source

Processionary Moth Exposure in Europe: Toxic–Irritant and Immunoglobulin E‐Mediated Endotypes, Diagnosis and Management

Clinical &Experimental Allergy, EarlyView.
Most reactions are toxic–irritant, driven by epithelial injury and neuro‐inflammatory activation. IgE‐mediated allergy is less common but may cause immediate systemic reactions. Endotype differentiation guides diagnosis, risk stratification and management.
Prasad Dasari, Josefine Haas, Wolfgang Rohe, Kai Gloyna, Christoph Viebahn, Susann Forkel, Michael Szardenings, Christine Stadelmann, Michael P. Schön, Timo Buhl   +9 more
wiley   +1 more source

Mitochondrially mediated RNA interference, a retrograde signaling system affecting nuclear gene expression. [PDF]

Heredity (Edinb)
Plazzi F, Le Cras Y, Formaggioni A, Passamonti M.   +3 more
europepmc   +1 more source

Continuing automated insulin delivery systems during hospitalisation with type 1 diabetes: A thematic literature review

Diabetic Medicine, EarlyView.
Abstract Aims A thematic review that identifies and summarises available evidence for people with Type 1 diabetes (T1D) continuing automated insulin delivery (AID) systems in the hospital setting, primarily with a focus on assessing the in‐hospital safety and efficacy of AID use.
Hannah Cunningham, Alicia Jenkins, David N. O'Neal, Melissa H. Lee   +3 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source