Results 1 to 10 of about 11,758 (252)

Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus [PDF]

Advanced Science
The vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans‐Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation.
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
doaj   +4 more sources

Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model [PDF]

Acta Neuropathologica Communications
Disruptions in synaptic transmission and plasticity are early hallmarks of Alzheimer’s disease (AD). Endosomal trafficking, mediated by the retromer complex, is essential for intracellular protein sorting, including the regulation of amyloid precursor ...
David Ramonet, Anna Daerr, Martin Hallbeck   +2 more
doaj   +5 more sources

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein [PDF]

Stem Cell Reports, 2018
Summary: Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer’s disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here,
Jessica E. Young, Lauren K. Fong, Harald Frankowski, Gregory A. Petsko, Scott A. Small, Lawrence S.B. Goldstein   +5 more
doaj   +7 more sources

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer [PDF]

Nature Communications
Retromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs).
Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins   +10 more
doaj   +3 more sources

Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response [PDF]

Cells, 2021
Sodium metabisulfite (Na2S2O5) is widely used as a preservative in the food and wine industry. However, it causes varying degrees of cellular damage to organisms.
Xuejiao Jin, Huihui Zhao, Min Zhou, Jie Zhang, Tingting An, Wenhao Fu, Danqi Li, Xiuling Cao, Beidong Liu   +8 more
doaj   +2 more sources

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

Neurobiology of Disease, 2012
The retromer complex plays an important role in intracellular transport, is highly expressed in the hippocampus, and has been implicated in the trafficking of the amyloid precursor protein (APP).
Akhil Bhalla, Christopher P. Vetanovetz, Etienne Morel, Zeina Chamoun, Gilbert Di Paolo, Scott A. Small   +5 more
doaj   +2 more sources

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

eLife, 2018
The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious ...
Bo Li, Chouin Wong, Shihong Max Gao, Rulan Zhang, Rongbo Sun, Yulong Li, Yan Song   +6 more
doaj   +2 more sources

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis [PDF]

Nature Communications, 2020
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer ...
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino   +18 more
doaj   +2 more sources

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50 [PDF]

, 2016
Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs
Cullen, Peter J., Dengjel, Jörn, Diedrich, Britta, Heesom, Kate J., Kvainickas, Arunas, Nägele, Heike, Orgaz, Ana Jimenez, Steinberg, Florian   +7 more
core   +4 more sources

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins [PDF]

, 2016
The retromer complex acts as a scaffold for endosomal protein complexes that sort integral membrane proteins to various cellular destinations. The retromer complex is a heterotrimer of VPS29, VPS35, and VPS26.
Adam P. Jellett, Arighi, Balana, Bean, Bean, Brett M. Collins, Burd, Cai, Chan, Chapin, Chris M. Danson, Cullen, Damseh, Frances C. Tilley, Freeman, Gallon, Gomez, Gustavsson, Harbour, Harbour, Hesketh, Ian McGough, Joubert, Kate J. Heesom, Kerr, Kevin A. Wilkinson, Kirsty J. McMillan, Lauffer, MacLeod, Matthew Gallon, McGough, McGough, Muhammad, Peter J. Cullen, Phillips-Krawczak, Popoff, Rovelet-Lecrux, Seaman, Seaman, Seaman, Seaman, Shannon, Shi, Small, Steinberg, Steinberg, Temkin, Thomas Clairfeuille, Vardarajan, Vilariño-Güell, Vilariño-Güell, Wang, Yoshimura, Zavodszky, Zimprich   +54 more
core   +5 more sources