Results 1 to 10 of about 9,718 (138)

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein [PDF]

Stem Cell Reports, 2018
Summary: Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer’s disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here,
Jessica E. Young, Lauren K. Fong, Harald Frankowski, Gregory A. Petsko, Scott A. Small, Lawrence S.B. Goldstein   +5 more
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Proteomic Identification of Cytokeratin 19 Association with Retromer Reveals a Connection with Cellular Dynamics [PDF]

Cells
Retromer is an evolutionarily conserved protein complex first identified in budding yeast. It was originally described for its essential role in endosome-to-Golgi retrieval of lysosomal hydrolase receptors. Retromer is now known to mediate trafficking of
Marcel Verges
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Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus [PDF]

Advanced Science
The vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans‐Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation.
Dingyang Zhang, Jiexiong Hu, Yonghe Hong, Yuping Fan, Minghui Peng, Yakubu Saddeeq Abubakar, Shujing Liang, Nan Jiang, Lili Lin, Xiaohong Pan, Huakun Zheng, Naweed I. Naqvi, Zonghua Wang, Wenhui Zheng   +13 more
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Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model [PDF]

Acta Neuropathologica Communications
Disruptions in synaptic transmission and plasticity are early hallmarks of Alzheimer’s disease (AD). Endosomal trafficking, mediated by the retromer complex, is essential for intracellular protein sorting, including the regulation of amyloid precursor ...
David Ramonet, Anna Daerr, Martin Hallbeck   +2 more
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Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer [PDF]

Nature Communications
Retromer mediates endosomal retrieval of transmembrane proteins in all eukaryotes and was first discovered in yeast in complex with the Vps5 and Vps17 sorting nexins (SNXs).
Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer, Brett M. Collins   +10 more
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Hybrid endosomal coats contain different classes of sorting nexins [PDF]

The EMBO Journal
Endosomes are protein sorting stations, where multiple membrane coats form tubulovesicular carriers exporting proteins to the Golgi, the plasma membrane, or endo-lysosomal compartments.
Navin Gopaldass, Sudeshna Roy Chowdhury, Ana Catarina Alves, Lydie Michaillat Mayer, Véronique Comte-Misérez, Andreas Mayer   +5 more
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Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function [PDF]

eLife
ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number of biological outputs includes control of tuberculosis in animal models.
Masroor Ahmad Paddar, Fulong Wang, Einar S Trosdal, Emily Hendrix, Yi He, Michelle R Salemi, Michal Mudd, Jingyue Jia, Thabata Duque, Ruheena Javed, Brett S Phinney, Vojo Deretic   +11 more
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The Sorting and Transport of the Cargo Protein CcSnc1 by the Retromer Complex Regulate the Growth, Development, and Pathogenicity of Corynespora cassiicola [PDF]

Journal of Fungi
In eukaryotes, the retromer complex is critical for the transport of cargo proteins from endosomes to the trans-Golgi network (TGN). Despite its importance, there is a lack of research on the retromer-mediated transport of cargo proteins regulating the ...
Shuyuan Cheng, Yunfei Long, Xiaoyang Zhang, Bing Liu, Shuilin Song, Genghua Li, Yuzhuan Hu, Lei Du, Quanxing Wang, Junxi Jiang, Guihong Xiong   +10 more
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Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2022
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby ...
Shun Yoshida, Shun Yoshida, Takafumi Hasegawa   +2 more
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Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. [PDF]

PLoS Pathogens, 2015
Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or the ...
Andreea Popa, Wei Zhang, Megan S Harrison, Kylia Goodner, Teymur Kazakov, Edward C Goodwin, Alex Lipovsky, Christopher G Burd, Daniel DiMaio   +8 more
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