Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites
Developmental Cell, 2021 Summary ER tubules form and maintain membrane contact sites (MCSs) with endosomes. How and why these ER-endosome MCSs persist as endosomes traffic and mature is poorly understood.
Haoxi Wu, Gia Voeltz
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A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission
Cell, 2018 Summary ER membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo sorting domains on endosome buds.
Qi Robert Zhong +2 more
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Lipid Transfer–Dependent Endosome Maturation Mediated by Protrudin and PDZD8 in Neurons
Frontiers in Cell and Developmental Biology, 2020 Endosome maturation refers to the conversion of early endosomes (EEs) to late endosomes (LEs) for subsequent fusion with lysosomes. It is an incremental process that involves a combination of endosome fusion and fission and which occurs at contact sites ...
Michiko Shirane
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A novel live-cell imaging assay reveals regulation of endosome maturation [PDF]
eLife, 2021 Cell-cell communication is an essential process in life, with endosomes acting as key organelles for regulating uptake and secretion of signaling molecules.
Maria Podinovskaia +3 more
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STARD 3 mediates endoplasmic reticulum‐to‐endosome cholesterol transport at membrane contact sites
EMBO Journal, 2017 StAR‐related lipid transfer domain‐3 (STARD3) is a sterol‐binding protein that creates endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad between sterol uptake and synthesis pathways, impacts the intracellular ...
Wendling Corinne +2 more
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Distribution and Co-localization of endosome markers in cells
Heliyon, 2019 Clathrin mediated endocytosis is one pathway for internalization of extracellular nano materials into cells [1, 2]. In this pathway, proteins attached to receptors and the internalized materials are encapsulated in clathrin coated membrane vesicles that ...
Lindsay J. Shearer, Nils O. Petersen
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A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes
Journal of Biological Chemistry, 2022 Exosomes are small extracellular vesicles of ∼30 to 150 nm that are secreted by all cells, abundant in all biofluids, and play important roles in health and disease. However, details about the mechanism of exosome biogenesis are unclear. Here, we carried
Francis K. Fordjour +4 more
semanticscholar +1 more source
Endosome positioning coordinates spatially-selective GPCR signaling
bioRxiv, 2022 G protein-coupled receptors (GPCRs), a class of critical regulators of mammalian physiology, can initiate unique functional responses depending on the subcellular compartment of their activation.
B. Willette, Nikoleta G. Tsvetanova
semanticscholar +1 more source
Cell Reports, 2023 Summary: Intracellular organelles of mammalian cells communicate with one another during various cellular processes. The functions and molecular mechanisms of such interorganelle association remain largely unclear, however.
Aya O. Satoh +8 more
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Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery
Biomedical Technology, 2023 In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-
Ruoyu Cheng +2 more
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