Results 11 to 20 of about 138,036 (346)
Early endosomes and endosomal coatomer are required for autophagy [PDF]
Journal of Cell Biology, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal pathway allowing content degradation.
Razi, M. +2 more
openaire +8 more sources
Fission of tubular endosomes triggers endosomal acidification and movement. [PDF]
PLoS ONE, 2011 The early endosome acts as a sorting station for internalized molecules destined for recycling or degradation. While recycled molecules are sorted and delivered to tubular endosomes, residual compartments containing molecules to be degraded undergo ...
Kumi Mesaki +4 more
doaj +4 more sources
Early Endosome Morphology in Health and Disease [PDF]
Advances in Experimental Medicine and Biology, 2018 Early endosomes are organelles that receive macromolecules and solutes from the extracellular environment. The major function of early endosomes is to sort these cargos into recycling and degradative compartments of the cell.
Gulpreet Kaur, Aparna Lakkaraju
semanticscholar +3 more sources
Endosome–lysosome fusion [PDF]
Biochemical Society Transactions, 2010 The delivery of endocytosed cargo to lysosomes occurs through kissing and direct fusion of late endosomes/MVBs (multivesicular bodies) and lysosomes. Live-cell and electron microscopy experiments together with cell-free assays have allowed us to describe the characteristics of the delivery process and determine the core protein machinery required for ...
J Paul, Luzio +2 more
openaire +3 more sources
The EMBO Journal, 2011 Being deeply connected to signalling, cell dynamics, growth, regulation, and defence, endocytic processes are linked to almost all aspects of cell life and disease. In this review, we focus on endosomes in the classical endocytic pathway, and on the programme of changes that lead to the formation and maturation of late endosomes/multivesicular bodies ...
Jatta Huotari, A. Helenius
semanticscholar +4 more sources
Endosome-dependent trafficking and secretion of ApoE. [PDF]
, 2023 (A-C) Microtubule-dependent motility of intracellular ApoE-CD63 double-positive structures. (A) Mean squared displacement (MSD) of general ApoE and CD63 trafficking in mock and colchicine-treated cells.
Karl Rohr (41937) +9 more
core +1 more source
PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission
Journal of Cell Biology, 2021 ORP10 localizes in a PI4P-dependent manner at ER–endosome membrane contact sites tethered by ORP9 and VAP, where it mediates countertransport of PI4P and PS. This in turn supplies endosomes with PS, thereby promoting EHD1 recruitment and endosome fission.
Asami Kawasaki +9 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 There is an urgent need to develop effective therapeutic strategies including immunomodulators to combat influenza A virus (IAV) infection. Influenza A viruses increase ROS production, which suppress anti-viral responses and contribute to pathological ...
Eunice E. To +17 more
doaj +1 more source
eLife, 2021 Actin filaments (F-actin) have been implicated in various steps of endosomal trafficking, and the length of F-actin is controlled by actin capping proteins, such as CapZ, which is a stable heterodimeric protein complex consisting of α and β subunits ...
Dawei Wang +6 more
doaj +1 more source
Regulation of Endosomal Sorting and Maturation by ER-Endosome Contact Sites
Contact, 2022 Endosomes are a heterogeneous population of intracellular organelles responsible for sorting, recycling, or transporting internalized materials for degradation.
Steve Jean, Sonya Nassari
doaj +1 more source