Results 21 to 30 of about 138,036 (346)
mBio, 2021 In filamentous fungi, 1,8-dihydroxynaphthalene (DHN) melanin is a major component of the extracellular matrix, endowing fungi with environmental tolerance and some pathogenic species with pathogenicity.
Xue Chen +11 more
doaj +1 more source
Nature Communications, 2020 Endosomes are compositionally dynamic organelles that regulate signaling, nutrient status and organelle quality by specifying whether material entering the cells will be shuttled back to the cell surface or degraded by the lysosome.
Yael Elbaz-Alon +8 more
semanticscholar +1 more source
Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking [PDF]
Journal of Cell Science, 2017 Retromer is a multimeric protein complex that mediates endosome-to-TGN and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's and Parkinson's disease.
G. Modica +7 more
semanticscholar +3 more sources
Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse
ACS Chemical Biology, 2020 Cell-penetrating peptides (CPPs) are capable of delivering membrane-impermeable cargoes (including small molecules, peptides, proteins, nucleic acids, and nanoparticles) into the cytosol of mammalian cells and have the potential to revolutionize ...
Ashweta Sahni, Ziqing Qian, D. Pei
semanticscholar +1 more source
A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling
eLife, 2021 Membrane protein recycling systems are essential for maintenance of the endosome-lysosome system. In yeast, retromer and Snx4 coat complexes are recruited to the endosomal surface, where they recognize cargos. They sort cargo and deform the membrane into
Sho W Suzuki +5 more
doaj +1 more source
eLife, 2021 In eukaryotic cells, intracellular components are organized by the microtubule motors cytoplasmic dynein-1 (dynein) and kinesins, which are linked to cargos via adaptor proteins.
Jenna R Christensen +6 more
doaj +1 more source
Plasticity of early endosomes [PDF]
Journal of Cell Science, 1992 ABSTRACT We observed that the structural organization of early endosomes was significantly modified after cell surface biotinylation followed by incubation in the presence of low concentrations of avidin. Under these conditions early endosomes increased in size to form structures which extended over several micrometres and which had an ...
Parton, R. G. +3 more
openaire +4 more sources
p120 catenin recruits HPV to γ-secretase to promote virus infection.
PLoS Pathogens, 2020 During internalization and trafficking, human papillomavirus (HPV) moves from the cell surface to the endosome where the transmembrane protease γ-secretase promotes insertion of the viral L2 capsid protein into the endosome membrane.
Mara Calypso Harwood +4 more
doaj +1 more source
Oncotarget, 2015 Phosphoinositide 3-kinase (PI3K) and AKT define a signaling network that regulates important biological processes such as cell cycle, survival, metabolism and motility, all of which are disrupted in cancer (Figure (Figure1)1) [1]. Hyperactivation of PI3K leads to increased production of phosphoinositide (PI) species such as PI(3,4,5)P3 and PI(3,4)P2 ...
Chew, Chen Li +2 more
openaire +2 more sources
Rabaptin5 is recruited to endosomes by Rab4a and Rabex5 to regulate endosome maturation [PDF]
, 2014 Membrane trafficking between organelles is fundamental to the existence of eukaryotic cells. A multitude of proteins is involved in membrane trafficking, acting as building blocks for transport carriers, regulators of transport, and targeting and fusion ...
Kälin, Simone
core +1 more source