Results 21 to 30 of about 10,879 (101)

Vaccinia Virus Infection Requires Maturation of Macropinosomes. [PDF]

, 2015
The prototypic poxvirus, vaccinia virus (VACV), occurs in two infectious forms, mature virions (MVs) and extracellular virions (EVs). Both enter HeLa cells by inducing macropinocytic uptake.
Mercer, Jason, Rizopoulos, Zaira, Balistreri, G, Kilcher, S, Mercer, J, Syedbasha, M, Kilcher, Samuel, Helenius, Ari, Balistreri, Giuseppe, Rizopoulos, Z, Syedbasha, Mohammedyaseen, Martin, Caroline K., Martin, CK, Helenius, A, Rizopoulos Z, Balistreri G, Syedbasha M, Kilcher S, Martin CK, Mercer J, Helenius A   +20 more
core   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
doaj   +1 more source

Astrocytes Are a Key Target for Neurotropic Viral Infection

Cells, 2023
Astrocytes are increasingly recognized as important viral host cells in the central nervous system. These cells can produce relatively high quantities of new virions.
Maja Potokar, Robert Zorec, Jernej Jorgačevski   +2 more
doaj   +1 more source

Structure of cellular ESCRT-III spirals and their relationship to HIV budding

eLife, 2014
The ESCRT machinery along with the AAA+ ATPase Vps4 drive membrane scission for trafficking into multivesicular bodies in the endocytic pathway and for the topologically related processes of viral budding and cytokinesis, but how they accomplish this ...
Anil G Cashikar, Soomin Shim, Robyn Roth, Michael R Maldazys, John E Heuser, Phyllis I Hanson   +5 more
doaj   +1 more source

Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking [PDF]

, 2017
Retromer is a multimeric protein complex that mediates endosome-to-TGN and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's and Parkinson's disease.
Peter K. Kim, Yip, Christopher M, Wurtele, Hugo, Lefrancois, Stephane, Sauvageau, Etienne, Graziana Modica, Stephane Lefrancois, Olga Skorobogata, Hugo Wurtele, Vissa, Adriano, Kim, Peter K, Christopher M. Yip, Etienne Sauvageau, Skorobogata, Olga, Modica, Graziana, Adriano Vissa   +15 more
core   +1 more source

The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

Cell Reports, 2020
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein ...
Alexandra Beilina, Luis Bonet-Ponce, Ravindran Kumaran, Jennifer J. Kordich, Morié Ishida, Adamantios Mamais, Alice Kaganovich, Sara Saez-Atienzar, David C. Gershlick, Dorien A. Roosen, Laura Pellegrini, Vlad Malkov, Matthew J. Fell, Kirsten Harvey, Juan S. Bonifacino, Darren J. Moore, Mark R. Cookson   +16 more
doaj   +1 more source

The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases

Membranes, 2012
Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration.
Fatemeh Safari, Shiro Suetsugu
doaj   +1 more source

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
core   +1 more source

Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions [PDF]

, 1985
The composition of hepatic endosome subfractions was compared directly with that of plasma membranes and Golgi-apparatus fractions. The neutral lipid and phospholipid composition of two endosome subfractions separated on Nycodenz gradients from a parent ...
Evans, William Howard, Hardison, W. G.
core   +4 more sources

Identification of Rab30 as a novel regulator of tubular endosomes

Cell Structure and Function
Tubular-shaped recycling endosomes, known as tubular endosomes, are present in certain types of cells, including HeLa cells, and they regulate the recycling of clathrin-independent endocytosed (CIE) cargo proteins to the plasma membrane.
Shumpei Nakashima, Mitsunori Fukuda
doaj   +1 more source