Results 31 to 40 of about 10,879 (101)

Atg8ylation as a general membrane stress and remodeling response

Cell Stress, 2021
The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj   +1 more source

Endosome maturation, transport and functions.

, 2014
Efficient sorting of the material internalized by endocytosis is essential for key cellular functions and represents a, if not the, major trafficking pathway in mammalian cells.
Vacca F, Gruenberg J, Scott CC
core   +1 more source

Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors

Frontiers in Cell and Developmental Biology, 2021
Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell stimulating factor but we now know that the cytokine plays a pivotal role in the orchestration of ...
Dirk Schmidt-Arras, Stefan Rose-John
doaj   +1 more source

CD40, autophagy and Toxoplasma gondii

Memorias do Instituto Oswaldo Cruz, 2009
Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles.
Carlos S Subauste
doaj   +1 more source

Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation [PDF]

, 2006
in mammalian cells, epidermal growth factor (EGF) stimulation promotes multivesicular body (MVB) formation and inward vesiculation within MVB. Annexin 1 is required for EGF-stimulated inward vesiculation but not MVB formation, demonstrating that MVB ...
C. E. Futter, M. Razi, Razi, M, Futter, CE   +3 more
core  

Rab11-FIP3 is a cell cycle-regulated phosphoprotein [PDF]

, 2012
<b>BACKGROUND:</b> Rab11 and its effector molecule, Rab11-FIP3 (FIP3), associate with recycling endosomes and traffic into the furrow and midbody of cells during cytokinesis.
Xinzi Yu, Simon, G, Glenn Simon, Prekeris, R., Simon, G., Matheson Johanne, Miller, MC, Collins, L.L., Miller, M Clare, Otani Tetsuhisa, Rytis Prekeris, M Clare Miller, Hayashi, S, Yu Xinzi, Prekeris Rytis, Yu, X, Otani, Tetsuhisa, Gould, Gwyn W, Matheson, J., Prekeris, R, Shigeo Hayashi, Gould, GW, Louise L Collins, Miller, M.C., Wu, C., Collins, LL, Christine Wu, Hayashi, Shigeo, Collins Louise L, Hayashi Shigeo, Simon, Glenn, Yu, Xinzi, Miller M Clare, Simon Glenn, Otani, T, Matheson, Johanne, Yu, X., Gould, G.W., Wu, Christine, Collins, Louise L, Gwyn W Gould, Tetsuhisa Otani, Wu, C, Johanne Matheson, Otani, T., Hayashi, S., Prekeris, Rytis, Wu Christine, Matheson, J, Gould Gwyn W   +49 more
core   +1 more source

Sorting Nexins in Protein Homeostasis

Cells, 2020
Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and damaged organelles from the cell by three major pathways; the ubiquitin-proteasome system, the autophagy-lysosomal pathway, and the endo-lysosomal pathway.
Sara E. Hanley, Katrina F. Cooper
doaj   +1 more source

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling

Nature Communications
Endosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na⁺/H⁺ Exchanger (NHE6) activates the late endosome master ...
YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L. Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, Eric M. Morrow   +12 more
doaj   +1 more source

Conformational change of apolipoprotein A-I and HDL formation from model membranes under intracellular acidic conditions

Journal of Lipid Research, 2008
The molecular mechanism by which nascent HDL forms via the interaction of apolipoprotein A-I (apoA-I) and transmembrane ABCA1 is poorly understood. Here, because ABCA1 has been reported to localize to acidic intracellular compartments, including the ...
Masakazu Fukuda, Minoru Nakano, Masakazu Miyazaki, Masafumi Tanaka, Hiroyuki Saito, Satoe Kobayashi, Masaharu Ueno, Tetsurou Handa   +7 more
doaj   +1 more source

Microscopy images for the endosome detection task

, 2019
This is the dataset images and the ground truth annotation of the locations of the ...
Lin Dongyun (6404678), Lin Dongyun
core   +1 more source