Results 51 to 60 of about 138,036 (346)

P Systems with Endosomes

open access: yesInternational Journal of Computers Communications & Control, 2009
P Systems are computing devices inspired by the structure and the func- tioning of a living cell. A P System consists of a hierarchy of membranes, each of them containing a multiset of objects, a set of evolution rules, and possibly other membranes. Evolution rules are applied to the objects of the same membrane with maximal parallelism.
BARBUTI, ROBERTO   +3 more
openaire   +7 more sources

Vanadate-inhibited endosome fusion. [PDF]

open access: yes, 2014
HEK293 cells stably expressing TLR4-CFP/MD-2 were untreated (A.), stimulated with Na3VO4 (500 µM) (B.), LPS-Cy5 (2 µg/ml) (C.), or prestimulated for 10 min with Na3VO4 and stimulated for 1 h with LPS (D.).
Roman Jerala (165758)   +3 more
core   +1 more source

The Parkinson’s Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network

open access: yesCell Reports, 2020
Summary: Mutations in Leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease (PD). However, the precise function of LRRK2 remains unclear. We report an interaction between LRRK2 and VPS52, a subunit of the Golgi-associated retrograde protein ...
Alexandra Beilina   +16 more
doaj   +1 more source

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

open access: yesCell, 2016
SUMMARY VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes through which lipids are exchanged across adjacent bilayers.
Rui Dong   +5 more
semanticscholar   +1 more source

The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases

open access: yesMembranes, 2012
Eukaryotic cells have complicated membrane systems. The outermost plasma membrane contains various substructures, such as invaginations and protrusions, which are involved in endocytosis and cell migration.
Fatemeh Safari, Shiro Suetsugu
doaj   +1 more source

Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

open access: yesJournal of Cell Biology, 2017
Contacts between endosomes and the endoplasmic reticulum (ER) promote endosomal tubule fission, but the mechanisms involved and consequences of tubule fission failure are incompletely understood. We found that interaction between the microtubule-severing
Rachel Allison   +13 more
semanticscholar   +1 more source

Identification of Rab30 as a novel regulator of tubular endosomes

open access: yesCell Structure and Function
Tubular-shaped recycling endosomes, known as tubular endosomes, are present in certain types of cells, including HeLa cells, and they regulate the recycling of clathrin-independent endocytosed (CIE) cargo proteins to the plasma membrane.
Shumpei Nakashima, Mitsunori Fukuda
doaj   +1 more source

Atg8ylation as a general membrane stress and remodeling response

open access: yesCell Stress, 2021
The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
doaj   +1 more source

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome

open access: yesFrontiers in Immunology, 2017
Toll-like receptor (TLR)-7 is an endosomal innate immune sensor capable of detecting single-stranded ribonucleic acid. TLR7-mediated induction of type I interferon and other inflammatory cytokine production is important in antiviral immune responses ...
Carlene Petes, N. Odoardi, Katrina Gee
semanticscholar   +1 more source

Guiding Endosomal Maturation [PDF]

open access: yesCell, 2010
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
Cabrera, Margarita, Ungermann, Christian
openaire   +2 more sources

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