Results 61 to 70 of about 10,879 (101)

SNX-BAR-mediated endosome tubulation is coordinated with endosome maturation

, 2011
Endosomal sorting is essential for cell homeostasis. Proteins targeted for degradation are retained in the maturing endosome vacuole while others are recycled to the cell surface or sorted to the biosynthetic pathway via tubular transport carriers ...
Verkade, P, Cullen, PJ, van Weering, JRT, Paul Verkade, Peter J. Cullen, Jan R.T. van Weering   +5 more
core   +1 more source

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes [PDF]

, 2008
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease.
B. O’Malley, J. A. D. Wattis, H. Blackburn, H. M. Byrne, L. Pickersgill, O'Malley, B, Panovska, J, Pickersgill, L, Blackburn, H, Byrne, HM, K. G. Jackson, Wattis, JAD, Jackson, KG, J. Panovska, Panovska, J., O'Malley, B., Pickersgill, L., Wattis, J.A.D., Jackson, K.G., Blackburn, H., Byrne, H.M.   +20 more
core   +1 more source

Cytoplasmic dynein and early endosome transport [PDF]

, 2015
Microtubule-based distribution of organelles/vesicles is crucial for the function of many types of eukaryotic cells and the molecular motor cytoplasmic dynein is required for transporting a variety of cellular cargos toward the microtubule minus ends ...
Xiang, X, Yao, X, Qiu, R, Arst, HN, Pealva, MA, Zhang, J   +5 more
core   +1 more source

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

Neurobiology of Disease, 2014
Dementia with Lewy bodies (DLB), Parkinson’s disease (PD) and multiple system atrophy are characterized by the deposition of disease-associated α-synuclein.
Gabor G. Kovacs, Leonid Breydo, Ryan Green, Viktor Kis, Gina Puska, Péter Lőrincz, Laura Perju-Dumbrava, Regina Giera, Walter Pirker, Mirjam Lutz, Ingolf Lachmann, Herbert Budka, Vladimir N. Uversky, Kinga Molnár, Lajos László   +14 more
doaj   +1 more source

Rab21 recruits EEA1 and competes with Rab5 for Rabex-5 activation

Frontiers in Cell and Developmental Biology
Rab5 is a key regulator of early endosomal traffic and fusion. It shares its localization and guanine nucleotide exchange factor Rabex-5 with the less characterized member of the Rab5 subfamily Rab21.
Francisco Yanguas, Cinzia Progida
doaj   +1 more source

PIKfyve regulates the endosomal localization of CpG oligodeoxynucleotides to elicit TLR9-dependent cellular responses.

PLoS ONE, 2013
TLR9 is a receptor for oligodeoxynucleotides that contain unmethylated CpG motifs (CpG). Because TLR9 resides in the endoplasmic reticulum during the quiescence state, CpG binding to TLR9 requires membrane trafficking, which includes the maturation of ...
Kaoru Hazeki, Masami Uehara, Kiyomi Nigorikawa, Osamu Hazeki   +3 more
doaj   +1 more source

A cycling cis-Golgi protein mediates endosome-to-Golgi traffic.

, 2018
Toxins can invade cells by using a direct endosome-to-Golgi endocytic pathway that bypasses late endosomes/prelysosomes. This is also a route used by endogenous proteins, including GPP130, which is an integral membrane protein retrieved via the bypass ...
Adam Linstedt (3889318), Rajalaxmi Natarajan (5062478)   +1 more
core   +1 more source

Vanadate-inhibited endosome fusion.

, 2014
HEK293 cells stably expressing TLR4-CFP/MD-2 were untreated (A.), stimulated with Na3VO4 (500 µM) (B.), LPS-Cy5 (2 µg/ml) (C.), or prestimulated for 10 min with Na3VO4 and stimulated for 1 h with LPS (D.).
Roman Jerala (165758), Mateja Manček-Keber (165733), Mojca Zelnikar (573284), Mojca Benčina (540231)   +3 more
core   +1 more source

ESCRT proteins, endosome organization and mitogenic receptor down-regulation

, 2009
Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface.
Woodman, Philip; id_orcid
core   +1 more source

SNX15 links clathrin endocytosis to the PtdIns(3)P early endosome independent of the APPL1 endosome

, 2013
Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss-of-function screen, we establish that of thirty human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting ...
Yarwood, Sam, Martin-Serrano, Juan, Cullen, Peter J, McGough, Ian J, Hemmings, Oliver J, May, Margaret T, Danson, Chris, Heesom, Kate J, Verkade, Paul, Brown, Edward, Carlton, Jeremy G, Carlton, Jeremy G; id_orcid   +11 more
core   +1 more source