Results 61 to 70 of about 138,036 (346)
Microscopy images for the endosome detection task [PDF]
, 2019 This is the dataset images and the ground truth annotation of the locations of the ...
Lin Dongyun (6404678), Lin Dongyun
core +1 more source
Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors
Frontiers in Cell and Developmental Biology, 2021 Interleukin-6 (IL-6) is the name-giving cytokine of a family of eleven members, including IL-6, CNTF, LIF, and IL-27. IL-6 was first recognized as a B-cell stimulating factor but we now know that the cytokine plays a pivotal role in the orchestration of ...
Dirk Schmidt-Arras, Stefan Rose-John
doaj +1 more source
Rab5-mediated endosome formation is regulated at the trans-Golgi network
Communications Biology, 2019 Early endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from
M. Nagano +3 more
semanticscholar +1 more source
CD40, autophagy and Toxoplasma gondii
Memorias do Instituto Oswaldo Cruz, 2009 Toxoplasmagondii represents a pathogen that survives within host cells by preventing the endosomal-lysosomal compartments from fusing with the parasitophorous vacuoles.
Carlos S Subauste
doaj +1 more source
Rab11 regulates recycling through the pericentriolar recycling endosome
Journal of Cell Biology, 1996 Small GTPases of the rab family are crucial elements of the machinery that controls membrane traffic. In the present study, we examined the distribution and function of rab11. Rab11 was shown by confocal immunofluorescence microscopy and EM to colocalize
O. Ullrich +4 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Role of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval
PLoS Biology, 2018 The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phenotype
Jennifer Hirst +4 more
semanticscholar +1 more source
Cloud storage for endosomes [PDF]
The EMBO Journal, 2016 Coordinated regulation of vesicle trafficking is critical for the proper functioning of a cell. The bulk of cellular transport vesicles are sequestered in a “perinuclear cloud”, with only a small fraction released to the cell periphery. Jongsma et al (2016) found that the ER‐associated E3 ubiquitin ligase RNF26 is responsible for establishing and ...
Teegan, Dellibovi-Ragheb +1 more
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Distinct roles for Tsg101 and Hrs in multivesicular body formation and inward vesiculation [PDF]
, 2006 in mammalian cells, epidermal growth factor (EGF) stimulation promotes multivesicular body (MVB) formation and inward vesiculation within MVB. Annexin 1 is required for EGF-stimulated inward vesiculation but not MVB formation, demonstrating that MVB ...
C. E. Futter +3 more
core