Results 71 to 80 of about 138,036 (346)

Sorting Nexins in Protein Homeostasis

Cells, 2020
Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and damaged organelles from the cell by three major pathways; the ubiquitin-proteasome system, the autophagy-lysosomal pathway, and the endo-lysosomal pathway.
Sara E. Hanley, Katrina F. Cooper
doaj   +1 more source

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Cell Reports, 2017
Summary Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the ...
Bethan S. Kilpatrick, Emily R. Eden, Leanne Hockey, Elizabeth Yates, C. Futter, Sandip Patel   +5 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Biogenesis of the sorting endosome: The role of Rab5 [PDF]

, 2000
Rab5 is a regulatory guanosine triphosphatase that is associated with the sorting endosome and participates in endosomal membrane fusion reactions. Recent experiments have provided insights into Rab5 function by demonstrating direct links between Rab5 ...
Woodman, Philip G.; id_orcid
core   +1 more source

Endosome maturation is orchestrated by inside-out proton signaling through a Na+/H+ exchanger and pH-dependent Rab GTPase cycling

Nature Communications
Endosome maturation requires lumen acidification. Is progressive lumen acidification sensed by cytosolic-side molecules driving maturation? We show here that proton efflux through the endosomal Na⁺/H⁺ Exchanger (NHE6) activates the late endosome master ...
YouJin Lee, Qing Ouyang, Li Ma, Morgan Fleishman, Hasib Aamir Riaz, Michael Schmidt, Jeffrey L. Dupree, Anupam Mondal, Priyesh Mohanty, Jeetain Mittal, Oliver Beckstein, David G. Lambright, Eric M. Morrow   +12 more
doaj   +1 more source

Conformational change of apolipoprotein A-I and HDL formation from model membranes under intracellular acidic conditions

Journal of Lipid Research, 2008
The molecular mechanism by which nascent HDL forms via the interaction of apolipoprotein A-I (apoA-I) and transmembrane ABCA1 is poorly understood. Here, because ABCA1 has been reported to localize to acidic intracellular compartments, including the ...
Masakazu Fukuda, Minoru Nakano, Masakazu Miyazaki, Masafumi Tanaka, Hiroyuki Saito, Satoe Kobayashi, Masaharu Ueno, Tetsurou Handa   +7 more
doaj   +1 more source

Annexin A1 Tethers Membrane Contact Sites that Mediate ER to Endosome Cholesterol Transport

Developmental Cell, 2016
Summary Membrane contact sites between the ER and multivesicular endosomes/bodies (MVBs) play important roles in endosome positioning and fission and in neurite outgrowth.
Emily R. Eden, Elena Sánchez-Heras, A. Tsapara, A. Sobota, T. Levine, C. Futter   +5 more
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Novel Factors at Endoplasmic Reticulum-Endosome Contact Sites [PDF]

, 2018
The endoplasmic reticulum is the cell’s platform for protein and lipid synthesis. Not only does the ER perform these functions, but it also regulates other organelles through membrane contact sites.
Hoyer, Melissa J.
core   +3 more sources

3D Computational Modeling of Defective Early Endosome Distribution in Human iPSC-Based Cardiomyopathy Models

Cells
Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes.
Hafiza Nosheen Saleem, Nadezda Ignatyeva, Christiaan Stuut, Stefan Jakobs, Michael Habeck, Antje Ebert   +5 more
doaj   +1 more source