Results 91 to 100 of about 138,036 (346)
Transport at the recycling endosome [PDF]
Current Opinion in Cell Biology, 2010 The recycling endosome (RE) has long been considered as a sub-compartment of the early endosome that recycles internalized cargoes to the plasma membrane. The RE is now appreciated to participate in a more complex set of intracellular itineraries. Key cargo molecules and transport factors that act in these pathways are being identified.
Victor W, Hsu, Rytis, Prekeris
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Rubicon controls endosome maturation as a Rab7 effector [PDF]
, 2010 The activation and recruitment of the small GTPase Rab7 to early endosome is a critical step for early to late endosome maturation, a process that requires the class III phosphatidylinositol 3-kinase (PI3KC3) and GTPase regulators. However, the molecular
Wiebke Westphal +4 more
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The Curious Case of Arenavirus Entry, and Its Inhibition
Viruses, 2012 Arenaviruses comprise a diverse family of enveloped negative-strand RNA viruses that are endemic to specific rodent hosts worldwide. Several arenaviruses cause severe hemorrhagic fevers in humans, including Junín and Machupo viruses in South America and ...
Joanne York, Jack H. Nunberg
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Moesin and cortactin control actin-dependent multivesicular endosome biogenesis. [PDF]
, 2016 W e have used in vivo and in vitro strategies to study the mechanisms of multivesicular en dosomes biogenesis . We f ou nd that, while annexinA2 and Arp2/3 mediate F - actin nucleation and branching, respectively , the ERM ...
Scott, CC +3 more
core +1 more source
Frontiers in Cellular Neuroscience, 2016 AGAP1 is an Arf1 GTPase activating protein that interacts with the vesicle-associated protein complexes adaptor protein 3 (AP-3) and Biogenesis of Lysosome Related Organelles Complex-1 (BLOC-1). Overexpression of AGAP1 in non-neuronal cells results in an
Miranda Arnold +11 more
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Synaptic Vesicle Recycling and the Endolysosomal System: A Reappraisal of Form and Function
Frontiers in Synaptic Neuroscience, 2022 The endolysosomal system is present in all cell types. Within these cells, it performs a series of essential roles, such as trafficking and sorting of membrane cargo, intracellular signaling, control of metabolism and degradation.
Daniela Ivanova +5 more
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ER–endosome contacts master the ins and outs of secretory endosomes
Journal of Cell Biology, 2022 What defines whether an endosome follows the degradative pathway or fuses with the plasma membrane to release exosomes? In this issue of JCB, Fredrik Verweij and colleagues (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202112032) demonstrate how secretory endosomes are guided by ER–endosome contacts to take a cellular detour and several identity ...
Eva Maria Wenzel, Camilla Raiborg
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Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source