Results 101 to 110 of about 138,036 (346)

Evidence for a symmetrical requirement for Rab5-GTP in in vitro endosome-endosome fusion [PDF]

, 1998
Early endosome fusion, which has been extensively characterized using an in vitro reconstitution assay, is Rab5-dependent. To examine the requirement for Rab5 on both fusion partners, we prepared cytosol and endosomes depleted of Rab5.
Stahl, D. Philip, Hoffenberg, Simon, Roberts, Richard, Barbieri, M. Alejandro, Dickey, F. Burton, Pomrehn, Andrea, Mukhopadhyay, Amitabha   +6 more
core   +1 more source

Intracellular Trafficking Pathways of Edwardsiella tarda: From Clathrin- and Caveolin-Mediated Endocytosis to Endosome and Lysosome

Frontiers in Cellular and Infection Microbiology, 2017
Edwardsiella tarda is a Gram-negative bacterium that can infect a broad range of hosts including humans and fish. Accumulating evidences have indicated that E. tarda is able to survive and replicate in host phagocytes.
Zhi-hai Sui, Zhi-hai Sui, Zhi-hai Sui, Haijiao Xu, Hongda Wang, Shuai Jiang, Shuai Jiang, Heng Chi, Heng Chi, Li Sun, Li Sun   +10 more
doaj   +1 more source

Massive Intracellular Biodegradation of Iron Oxide Nanoparticles Evidenced Magnetically at Single-Endosome and Tissue Levels.

ACS Nano, 2016
Quantitative studies of the long-term fate of iron oxide nanoparticles inside cells, a prerequisite for regenerative medicine applications, are hampered by the lack of suitable biological tissue models and analytical methods.
Francois Mazuel, Ana Espinosa, N. Luciani, M. Reffay, R. Le Borgne, L. Motte, K. Desboeufs, A. Michel, T. Pellegrino, Y. Lalatonne, C. Wilhelm   +10 more
semanticscholar   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The role of the recycling endosome in regulating lamellipodia formation and macrophage migration [PDF]

, 2011
Cell migration is a highly complex process that requires the extension of cell membrane in the direction of travel. This membrane is continuously remodeled to expand the leading edge and alter its membrane properties.
Murray, Rachael, Veale, Kelly J., Offenhäuser, Carolin, Murray, Rachael Z., Veale, Kelly   +4 more
core   +1 more source

Endosomal and Phagosomal SNAREs [PDF]

Physiological Reviews, 2018
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein family is of vital importance for organelle communication. The complexing of cognate SNARE members present in both the donor and target organellar membranes drives the membrane fusion required for intracellular transport.
Ilse Dingjan, Peter T. A. Linders, Danielle R. J. Verboogen, Natalia H. Revelo, Martin ter Beest, Geert van den Bogaart   +5 more
openaire   +4 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Preferential association of syntaxin 8 with the early endosome [PDF]

, 2000
Members of the syntaxin family play a fundamental role in vesicle docking and fusion of diverse transport events. We have molecularly characterized syntaxin 8, a novel member of the syntaxin family.
Loh, E., Subramaniam, V. N., Horstmann, H., Habermann, A., Hong, W., Xu, Y., Griffiths, G., Coe, J., Hong, W. J., Subramaniam, V.N.   +9 more
core  

SNX15 links clathrin endocytosis to the PtdIns(3)P early endosome independent of the APPL1 endosome [PDF]

, 2013
Sorting nexins (SNXs) are key regulators of the endosomal network. In designing an RNAi-mediated loss-of-function screen, we establish that of thirty human SNXs only SNX3, SNX5, SNX9, SNX15 and SNX21 appear to regulate EGF receptor degradative sorting ...
Yarwood, Sam, Martin-Serrano, Juan, Cullen, Peter J, McGough, Ian J, Hemmings, Oliver J, May, Margaret T, Danson, Chris, Heesom, Kate J, Verkade, Paul, Brown, Edward, Carlton, Jeremy G   +10 more
core   +1 more source