Results 81 to 90 of about 138,036 (346)
Frontiers in Immunology, 2018 Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance.
Steve Swain +8 more
doaj +1 more source
SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway
MedComm, 2021 SARS‐CoV‐2 is an enveloped positive‐sense RNA virus that depends on host factors for all stages of its life. Membrane receptor ACE2 is a well‐established factor for SARS‐CoV‐2 docking.
Lin Zhao +5 more
doaj +1 more source
Drosophila Rab2 controls endosome-lysosome fusion and LAMP delivery to late endosomes
Autophagy, 2018 Rab2 is a conserved Rab GTPase with a well-established role in secretory pathway function and phagocytosis. Here we demonstrate that Drosophila Rab2 is recruited to late endosomal membranes, where it controls the fusion of LAMP-containing biosynthetic ...
V. K. Lund, K. Madsen, O. Kjaerulff
semanticscholar +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
A new Rab7 effector controls phosphoinositide conversion in endosome maturation [PDF]
, 2017 Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol.
Bettina Winckler, James E. Casanova
core +1 more source
The many disguises of the signalling endosome
FEBS Letters, 2018 Neurons are highly complex and polarised cells that must overcome a series of logistic challenges to maintain homeostasis across their morphological domains.
David Villarroel-Campos +2 more
semanticscholar +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Syntaxin 11 binds Vti1b and regulates late endosome to lysosome fusion in macrophages [PDF]
, 2011 Syntaxin 11 (Stx11) is a SNARE protein enriched in cells of the immune system. Loss or mutation of Stx11 results in familial hemophagocytic lymphohistiocytosis type-4 (FHL-4), an autosomal recessive disorder of immune dysregulation characterized by high ...
Murray, Rachael +14 more
core +1 more source
Septins as modulators of endo-lysosomal membrane traffic
Frontiers in Cell and Developmental Biology, 2016 Septins constitute a family of GTP-binding proteins, which assemble into non-polar filaments in a nucleotide-dependent manner. These filaments can be recruited to negatively charged membrane surfaces.
Kyungyeun Song +2 more
doaj +1 more source
Cancer Biology & Medicine, 2020 Objectives: Improper activation of Wnt/β-catenin signaling has been implicated in human diseases. Beyond the well-studied glycogen synthase kinase 3β (GSK3β) and casein kinase 1 (CK1), other kinases affecting Wnt/β-catenin signaling remain to be defined.
Danmin Ou +10 more
doaj +1 more source