Results 101 to 110 of about 9,787 (196)

Retromer localizes to autophagosomes during HCV replication [PDF]

Virologica Sinica, 2017
In summary, we propose a model for the role of retromer in HCV replication. Upon HCV infection, retromer may provide double-membrane autophagosomal membranes for HCV replication. Our studies suggested a novel link between retromer and autophagy in HCV replication, which may provide new therapeutic targets for antiviral therapy.
Peiqi Yin, Zhi Hong, Leiliang Zhang, Youyang Ke   +3 more
openaire   +2 more sources

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson’s disease

Cell Death Discovery
Since the identification of vacuolar protein sorting (VPS) 35, as a causative molecule for familial Parkinson’s disease (PD), retromer-mediated endosomal machinery has been a rising factor in the pathogenesis of the disease.
Shun Yoshida, Takafumi Hasegawa, Takaaki Nakamura, Kazuki Sato, Naoto Sugeno, Shun Ishiyama, Kiyotoshi Sekiguchi, Muneshige Tobita, Atsushi Takeda, Masashi Aoki   +9 more
doaj   +1 more source

Actin polymerization in the endosomal pathway, but not on the Coxiella-containing vacuole, is essential for pathogen growth. [PDF]

PLoS Pathogens, 2018
Coxiella burnetii is an intracellular bacterium that replicates within an expansive phagolysosome-like vacuole. Fusion between the Coxiella-containing vacuole (CCV) and late endosomes/multivesicular bodies requires Rab7, the HOPS tethering complex, and ...
Heather E Miller, Charles L Larson, Robert A Heinzen   +2 more
doaj   +1 more source

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. [PDF]

, 2016
Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ...
Benovic, Jeffrey L., Bowman, Shanna L., Du, Yang, Irannejad, Roshanak, Puthenveedu, Manojkumar A., Tian, Xufan, von Zastrow, Mark   +6 more
core   +2 more sources

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Harold Bae, Catherine E Costello, Matthew Au, Lingyi Lynn Deng, Mengze Li, Qingyan Xiang, Heeju Noh, Lance Pflieger, Cory Funk, Noa Rappaport, Marianne Nygaard, Meghan I Short, Michael Brent, Stefano Monti, Stacy L Andersen, Thomas T Perls   +20 more
wiley   +1 more source

The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking

eLife, 2018
The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious ...
Bo Li, Chouin Wong, Shihong Max Gao, Rulan Zhang, Rongbo Sun, Yulong Li, Yan Song   +6 more
doaj   +1 more source

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis

Nature Communications, 2020
ALS is a neurodegenerative disease characterized by loss of motor neurons. Here, the authors showed that reduced levels of the VSP35 subunit in the retromer complex is a conserved ALS feature and identified a new lead compound increasing retromer ...
Luca Muzio, Riccardo Sirtori, Davide Gornati, Simona Eleuteri, Andrea Fossaghi, Diego Brancaccio, Leonardo Manzoni, Linda Ottoboni, Luca De Feo, Angelo Quattrini, Eloise Mastrangelo, Luca Sorrentino, Emanuele Scalone, Giancarlo Comi, Luciana Marinelli, Nilo Riva, Mario Milani, Pierfausto Seneci, Gianvito Martino   +18 more
doaj   +1 more source

Single-cell-based system to monitor carrier driven cellular auxin homeostasis [PDF]

, 2013
Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular
Barbez, Elke, Friml, Jiří, Kleine-Vehn, Jürgen, Laňková, Martina, Maizel, Alexis, Pařezová, Markéta, Petrášek, Jan, Zažímalová, Eva   +7 more
core   +3 more sources

Alzheimer's disease Stage 1 and 2: Biology, diagnostics, and treatment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Advances in biomarker technology, digital cognitive assessments, and amyloid‐targeting therapies have redefined the opportunities for accurate and early diagnosis and care of Alzheimer's disease (AD). These advances also create new possibilities for intervention before the onset of cognitive impairment.
Suzanne E. Schindler, Oskar Hansson, Alicia Algeciras‐Schimnich, Jalayne J. Arias, Brent Beasley, Gill Farrar, Nicole R. Fowler, Sarah M. Hartz, Clifford R. Jack, Linus Jönsson, Geoffrey Joyce, Claire J. Lansdall, Paul Maruff, Niklas Mattsson‐Carlgren, Catherine Jane Mummery, Jennifer Murphy, Hamid Okhravi, Ronald C. Petersen, Rema Raman, Christopher Randolph, Marie Reeberg Sass, Eric M. Reiman, Gemma Salvadó, Michael Schöll, Eric Siemers, Reisa A. Sperling, Tricia Thornton‐Wells, Rosanna Tortelli, Duygu Tosun, Lawren Vandevrede, Nicolas Villain, Stacie Weninger, Alette M. Wessels, Jin Zhou, Maria C. Carrillo, Christopher J. Weber   +35 more
wiley   +1 more source