Results 111 to 120 of about 11,758 (252)
Abeta and Tau impair retromer‐mediated cargo trafficking via distinct mechanisms [PDF]
, 2023 Hui Ye, Vanuli Arya, Joshua M. Shulman
openalex +1 more source
Journal of Inflammation Research, 2021 Alessia Filippone, Tiffany Smith, Domenico Pratico Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USACorrespondence: Domenico PraticoAlzheimer’s Center at Temple, Lewis Katz School of Medicine ...
Filippone A, Smith T, Pratico D
doaj
Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy. [PDF]
PLoS ONE, 2017 Vps35 (vacuolar protein sorting 35) is a major component of retromer that selectively promotes endosome-to-Golgi retrieval of transmembrane proteins. Dysfunction of retromer is a risk factor for the pathogenesis of Parkinson's disease (PD) and Alzheimer ...
Wei Liu +6 more
doaj +1 more source
Movement Disorders, Volume 40, Issue 12, Page 2746-2769, December 2025.Abstract Background The RAB32 p.Ser71Arg variant is a novel cause of monogenic Parkinson's disease (PD), for which detailed phenotypic information is currently scarce. Objectives Our aim was to clinically and biologically characterize individuals with PARK‐RAB32 to gain insights into genotype–phenotype relationships, disease severity, and underlying ...
Teresa Kleinz +27 more
wiley +1 more source
VPS35 or retromer as a potential target for neurodegenerative disorders: barriers to progress. [PDF]
Expert Opin Ther TargetsIntroduction Vacuolar Protein Sorting 35 (VPS35) is pivotal in the retromer complex, governing transmembrane protein trafficking within cells, and its dysfunction is implicated in neurodegenerative diseases.
Wu A, Lee D, Xiong WC.
europepmc +2 more sources
Traffic into silence: endomembranes and post-transcriptional RNA silencing. [PDF]
, 2014 microRNAs (miRNAs) and small interfering RNAs (siRNAs) are small RNAs that repress gene expression at the post-transcriptional level in plants and animals. Small RNAs guide Argonaute-containing RNA-induced silencing complexes to target RNAs in a sequence-
Chen, Xuemei +2 more
core +3 more sources
From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae
Yeast, Volume 42, Issue 12, Page 283-302, December 2025.Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior +2 more
wiley +1 more source
Exosome Tethering Requires Tetherin Homodimerisation
Biology of the Cell, Volume 117, Issue 12, December 2025.Rather than being released from cells, exosomes can be retained at the plasma membrane via the protein tetherin. Here, we demonstrate that exosome tethering requires the formation of tetherin homodimers, and that mutations in tetherin that impair homodimer formation impair exosome tethering.
Yağmur Yıldızhan +5 more
wiley +1 more source
Actin polymerization in the endosomal pathway, but not on the Coxiella-containing vacuole, is essential for pathogen growth. [PDF]
PLoS Pathogens, 2018 Coxiella burnetii is an intracellular bacterium that replicates within an expansive phagolysosome-like vacuole. Fusion between the Coxiella-containing vacuole (CCV) and late endosomes/multivesicular bodies requires Rab7, the HOPS tethering complex, and ...
Heather E Miller +2 more
doaj +1 more source
Genetic Correlates of Brain Aging on MRI and Cognitive Test Measures: A Genome-Wide Association and Linkage Analysis in the Framingham Study [PDF]
, 2007 BACKGROUND: Brain magnetic resonance imaging (MRI) and cognitive tests can identify heritable endophenotypes associated with an increased risk of developing stroke, dementia and Alzheimer's disease (AD).
Atwood, Larry D. +10 more
core +3 more sources