Results 121 to 130 of about 11,758 (252)

Retromer localizes to autophagosomes during HCV replication [PDF]

Virologica Sinica, 2017
In summary, we propose a model for the role of retromer in HCV replication. Upon HCV infection, retromer may provide double-membrane autophagosomal membranes for HCV replication. Our studies suggested a novel link between retromer and autophagy in HCV replication, which may provide new therapeutic targets for antiviral therapy.
Peiqi Yin, Zhi Hong, Leiliang Zhang, Youyang Ke   +3 more
openaire   +2 more sources

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5 [PDF]

, 2017
Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins.
Bärlocher, K, Hilbi, H, Hohl, M, Hutter, CAJ, Letourneur, F, Seeger, MA, Steiner, B, Swart, AL, Welin, A   +8 more
core   +4 more sources

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration [PDF]

, 2017
Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD).
Bandopadhyay, Rina, Daniel, Guillaume, Fiser, Aris, Glauser, Liliane, Lees, Andrew, Lewis, Patrick A., Moore, Darren J., Moser, Roger, Schneider, Bernard L., Sheerin, Una-Marie, Troncoso, Juan C., Tsika, Elpida   +11 more
core  

Single-cell-based system to monitor carrier driven cellular auxin homeostasis [PDF]

, 2013
Background: Abundance and distribution of the plant hormone auxin play important roles in plant development. Besides other metabolic processes, various auxin carriers control the cellular level of active auxin and, hence, are major regulators of cellular
Barbez, Elke, Friml, Jiří, Kleine-Vehn, Jürgen, Laňková, Martina, Maizel, Alexis, Pařezová, Markéta, Petrášek, Jan, Zažímalová, Eva   +7 more
core   +3 more sources

In an older‐age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p‐tau217

Alzheimer's &Dementia, Volume 21, Issue 11, November 2025.
Abstract INTRODUCTION Asymptomatic extracranial carotid atherosclerotic disease (aECAD) has been associated with Alzheimer's disease (AD), but the earliest cognitive deficits in this hallmark vascular population are largely unknown. METHODS A total of 182 participants 50–85 years of age with ≥2 vascular comorbidities with/without aECAD were evaluated ...
Summan Zahra, Scott R. French, Juan C. Arias, Madeline Ally, Haley Wiskoski, Cris Escareno, Emma Heitkamp, Franchell Vazquez, Madison Hillis, Gavin Culwell, Karthik Ainapurapu, Caronae M. Howell, Kevin Johnson, Deniz Karakay, Karthik Rayasam, Lindsay Taylor, Cody Kraemer, Luis Leon, Scott Berman, Federico Yanquez, Joshua Balderman, Joseph Sabat, Olivia Hung, Layla Lucas, Edward J. Bedrick, Francesca Vitali, Raza Mushtaq, Maria Altbach, Theodore P. Trouard, Ali Bilgin, Eric M. Reiman, Gene E. Alexander, Craig C. Weinkauf   +32 more
wiley   +1 more source

From Mitochondria to Immunity: The Emerging Roles of Mitochondria‐Derived Vesicles and Small Extracellular Vesicles in Cellular Communication and Disease

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
ABSTRACT According to the endosymbiotic theory of mitochondrial origin, an α‐proteobacterium entered a prokaryotic cell and, through symbiosis, evolved into the mitochondria—the powerhouse of the cell. Like other bacteria, the α‐proteobacteria generate their own extracellular vesicles (EVs), a trait that was passed onto the mitochondria, enabling them ...
Rostyslav Horbay, Vasyl Syrvatka, Artem Bedzay, Mikaela van der Merwe, Dylan Burger, Shawn T. Beug   +5 more
wiley   +1 more source

Mroh1, a lysosomal regulator localized by WASH-generated actin [PDF]

, 2017
The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent.
Altschul, Andrade, Buchan, Buckley, Burki, Carnell, Chisholm, de Marcos Lousa, Derivery, Derivery, Derivery, Duleh, Finn, Fox, Gautreau, Gillingham, Gomez, Gomez, Grinthal, Groves, Harbour, Harbour, Hashiguchi, Helfer, Holliday, Huotari, Huss, Jia, Jia, King, King, Kuspa, Lima, Marshansky, Mezulis, Mitchell, Nagel, Park, Puthenveedu, Schneider, Shi, Simpson, Smith, Trinkle-Mulcahy, Veltman, Veltman, Veltman, Vetter, Xu, Yang, Yang, Zech   +51 more
core   +2 more sources

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, Volume 25, Issue 21-22, Page 102-150, November 2025.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Unveiling the cryo-EM structure of retromer

Biochemical Society Transactions, 2020
Retromer (VPS26/VPS35/VPS29) is a highly conserved eukaryotic protein complex that localizes to endosomes to sort transmembrane protein cargoes into vesicles and elongated tubules. Retromer mediates retrieval pathways from endosomes to the trans-Golgi network in all eukaryotes and further facilitates recycling pathways to the plasma membrane in ...
Mintu Chandra, Amy K. Kendall, Lauren P. Jackson   +2 more
openaire   +3 more sources

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5

Nature Communications, 2016
Retromer is recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. Here, the authors report the interaction between a GTPase-activating protein TBC1d5 and Rab7, examine the biochemical details of the interaction with retromer, and discuss ...
Da Jia, Jin-San Zhang, Fang Li, Jing Wang, Zhihui Deng, Mark A. White, Douglas G. Osborne, Christine Phillips-Krawczak, Timothy S. Gomez, Haiying Li, Amika Singla, Ezra Burstein, Daniel D. Billadeau, Michael K. Rosen   +13 more
doaj   +1 more source