Results 121 to 130 of about 9,787 (196)

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5 [PDF]

, 2017
Legionella pneumophila can cause Legionnaires’ disease and replicates intracellularly in a distinct Legionella-containing vacuole (LCV). LCV formation is a complex process that involves a plethora of type IV-secreted effector proteins.
Bärlocher, K, Hilbi, H, Hohl, M, Hutter, CAJ, Letourneur, F, Seeger, MA, Steiner, B, Swart, AL, Welin, A   +8 more
core   +4 more sources

Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection

Nature Communications, 2016
The retromer complex is a multi-protein component of the endosomal protein sorting machinery. Here, Sangaré et al. identify unique features in the retromer complex of the parasite Toxoplasma gondii, and show that it is crucial for the biogenesis of ...
Lamba Omar Sangaré, Tchilabalo Dilezitoko Alayi, Benoit Westermann, Agnes Hovasse, Fabien Sindikubwabo, Isabelle Callebaut, Elisabeth Werkmeister, Frank Lafont, Christian Slomianny, Mohamed-Ali Hakimi, Alain Van Dorsselaer, Christine Schaeffer-Reiss, Stanislas Tomavo   +12 more
doaj   +1 more source

Mroh1, a lysosomal regulator localized by WASH-generated actin [PDF]

, 2017
The steps leading to constitutive exocytosis are poorly understood. In Dictyostelium WASH complex mutants, exocytosis is blocked, so cells that take up fluorescent dextran from the medium retain it and remain fluorescent.
Altschul, Andrade, Buchan, Buckley, Burki, Carnell, Chisholm, de Marcos Lousa, Derivery, Derivery, Derivery, Duleh, Finn, Fox, Gautreau, Gillingham, Gomez, Gomez, Grinthal, Groves, Harbour, Harbour, Hashiguchi, Helfer, Holliday, Huotari, Huss, Jia, Jia, King, King, Kuspa, Lima, Marshansky, Mezulis, Mitchell, Nagel, Park, Puthenveedu, Schneider, Shi, Simpson, Smith, Trinkle-Mulcahy, Veltman, Veltman, Veltman, Vetter, Xu, Yang, Yang, Zech   +51 more
core   +2 more sources

Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. [PDF]

, 2012
Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles remains challenging. Here, we describe a multivariate proteomics approach to analyzing clathrin-coated vesicles (CCVs) from HeLa cells. siRNA knockdown of coat
Abou Jamra, Antrobus, Bergeron, Blondeau, Booth, Borner, Burgos, Chekulaeva, Cheng, Cole, Cox, Daniela A. Sahlender, Dell’Angelica, Dergai, Drenckhahn, Dunkley, Eisenberg, Field, Gary S. Bhumbra, Georg H.H. Borner, Girard, Hall, Hirst, Hirst, Hirst, Hirst, Hubner, Ishihama, Janes, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, McGough, McPherson, Miller, Moreno-De-Luca, Newmyer, Ohta, Ong, Patrycja Kozik, Robin Antrobus, Robinson, Robinson, Royle, Schneider, Schröder, Seaman, Shimizu, Simpson, Stenmark, Tanenbaum, Tiwari, Traub, Verkerk, Yoshimura   +54 more
core   +1 more source

Amino acid substitution equivalent to human chorea-acanthocytosis I2771R in yeast Vps13 protein affects its binding to phosphatidylinositol 3-phosphate [PDF]

, 2017
The rare human disorder chorea-acanthocytosis (ChAc) is caused by mutations in hVPS13A gene. The hVps13A protein interacts with actin and regulates the level of phosphatidylinositol 4-phosphate (PI4P) in the membranes of neuronal cells.
Ayscough, K.R., Flis, K., Grynberg, M., Kaminska, J., Rzepnikowska, W., Urbanek, A., Zoladek, T.   +6 more
core   +2 more sources

The Retromer Complex: From Genesis to Revelations

Trends in Biochemical Sciences, 2021
The retromer complex has a well-established role in endosomal protein sorting, being necessary for maintaining the dynamic localisation of hundreds of membrane proteins that traverse the endocytic system. Retromer function and dysfunction is linked with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, and many pathogens, both ...
openaire   +3 more sources

Sortilin is associated with the chlamydial inclusion and is modulated during infection [PDF]

, 2016
© 2016. Published by The Company of Biologists Ltd. Chlamydia species are obligate intracellular pathogens that have a major impact on human health. The pathogen replicates within an intracellular niche called an inclusion and is thought to rely heavily ...
Huston, WM, Kerr, MC, Teasdale, RD, Teo, WX   +3 more
core   +1 more source

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways. [PDF]

, 2012
The FERM-like domain-containing sorting nexins of the SNX17/SNX27/SNX31 family have been proposed to mediate retrieval of transmembrane proteins from the lysosomal pathway.
Arighi, Bass, Burden, Carlton, Carlton, Caswell, Cullen, Cullen, Dozynkiewicz, Florian Steinberg, Ghai, Gomez, Grant, Harterink, Huss, Johannes, Jović, Kate J. Heesom, Lane, Lauffer, Lee, Li, Lobert, Margadant, Mark D. Bass, Moser, Muhammad, Peter J. Cullen, Roca-Cusachs, Salicioni, Seaman, Seet, Stockinger, Temkin, Tiwari, van Kerkhof, Wassmer, Wassmer, White, Worby, Zech   +40 more
core   +2 more sources

BLOC-1 and BLOC-3 regulate VAMP7 cycling to and from melanosomes via distinct tubular transport carriers. [PDF]

, 2016
Endomembrane organelle maturation requires cargo delivery via fusion with membrane transport intermediates and recycling of fusion factors to their sites of origin.
Amanda Acosta-Ruiz, Anderson, Barlowe, Bennett, Boissy, Bonifacino, Bright, Brooks, Bultema, Bultema, Burgo, Burgo, Cai, Chen, Chiang, Cullinane, Cédric Delevoye, Danglot, Danglot, David J. Owen, Delevoye, Delevoye, Dell’Angelica, Dennis, Di Pietro, Domanska, Dorothy C. Bennett, Elena V. Sviderskaya, Fader, Fader, Gardner, Geoffrey G. Hesketh, Gerondopoulos, Ghiani, Gordon, Graça Raposo, Hesketh, Huang, Huizing, Ilse Hurbain, J. Paul Luzio, Jahn, Jani, Kent, Lane, Loftus, Lopes, Luzio, Marks, Martina, Martinez-Arca, Maryse Romao, McGough, Megan K. Dennis, Meng, Michael S. Marks, Mohrmann, Molino, Morita, Nazarian, Newell-Litwa, Nguyen, Nguyen, Orlow, Osanai, Philip S. Goff, Prekeris, Pryor, Pu, Richmond, Ryder, Salazar, Schäfer, Setty, Setty, Seward, Sitaram, Sitaram, Suzuki, Sviderskaya, Takeuchi, Tamura, Tamura, Theos, Thierry Galli, Vijayasaradhi, Wade, Wang, Wasmeier, Wassmer, Wei, Wei, Yatsu, Zhang   +93 more
core   +2 more sources