Results 131 to 140 of about 9,787 (196)

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Nature Communications, 2018
Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C.
Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen   +8 more
doaj   +1 more source

Oxidation of retromer complex controls mitochondrial translation. [PDF]

Nature
Reactive oxygen species (ROS) underlie human pathologies including cancer and neurodegeneration1,2. However, the proteins that sense ROS levels and regulate their production through their cysteine residues remain ill defined. Here, using systematic base-editing and computational screens, we identify cysteines in VPS35, a member of the retromer ...
Zhang J, Ali MY, Chong HB, Tien PC, Woods J, Noble C, Vornbäumen T, Ordulu Z, Possemato AP, Harry S, Fonticella JM, Fellah L, Harrison D, Ge M, Khandelwal N, Huang Y, Chauvin M, Bischof AT, Hambelton GM, Gohar MF, Zhang S, Choi M, Bouberhan S, Oliva E, Mino-Kenudson M, Pavlova NN, Lawrence M, Gainor JF, Beausoleil SA, Bardeesy N, Mostoslavsky R, Pépin D, Ott CJ, Liau B, Bar-Peled L.   +34 more
europepmc   +3 more sources

Wnt signalling and cancer stem cells [PDF]

, 2009
[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult ...
A. Bafico, A. Bejsovec, A. Bejsovec, A. Jenny, A. Mani, A. Mudher, A. Patapoutian, A. Rattner, A. Safholm, A.E. Chen, A.J. Mikels, A.J. Simmonds, A.M. Jacobson, B. Hoang, C. Bänziger, C. Genderen van, C. Mosimann, C. Wilson, C. Wu, C.T. Jordan, D. Strutt, D. Wawrzak, D.A. Tice, D.M. Lehman, D.R. Soprano, D.Y. Coudreuse, E. Park, E. Piters, F. Li, F. Li, F. Li, F. Li, F. Li, F. Reichsman, F.J. Staal, G. Aslanidi, G. Schulte, G.S. Wilkie, H. Hikasa, H. Hu, H. Huang, H. Liang, H.G. Palmer, H.S. Melkonyan, I. Nishisho, I. Oishi, J. Calisto De, J. Dejmek, J. Huelsken, J. Huelsken, J. Mao, J. Shao, J.A. Pospisilik, J.C. Hsieh, J.D. Axelrod, J.H. Xiao, J.R. Seifert, Jesús Espada, K. Bartscherer, K. Itoh, K. Lin, K. Maiese, K. Maiese, K. Maiese, K.A. Kim, K.W. Kinzler, L. Alonso, L. Barandon, L. Dubois, L. Ling, L. Ma, L. Monnier, L. Ouko, L. Song, L.I. Rachek, L.R. Howe, M. Boutros, M. D’Amico, M. Heuvel van den, M. Kishida, M. Vergés, M. Wehrli, M. Wetering van de, M.D. Castellone, M.J. Thun, M.M. Moline, Moisés B. Calvo, N. Barker, N. Kinoshita, N. Kremenevskaja, N.A. Graham, N.S. Tolwinski, O. Aguilera, P. Polakis, P. Salins, P.J. Morin, P.J. Morin, R. Nusse, R. Nusse, R. Nusse, R.H. Giles, R.J. Garriock, R.T. Moon, S. Fre, S. Shah, S. Shah, S. Shibamoto, S. Sumanas, S. Wu, S.G. Hwang, S.M. Foord, Silvia Díaz-Prado, T. Grigoryan, T. Ishitani, T. Ishitani, T. Liu, T. Matsui, T. Reya, T. Reya, T.A. Westfall, V. Greco, V. Korinek, V. Korinek, V.A. Schans van de, V.L. Katanaev, Vanessa Medina, W. Ching, W. Lu, W. Wu, W. Yan, W.C. Forrester, W.E. Lowry, X. Guo, X. He, X. Lin, X. Tu, X. Zeng, Y.F. Guo, Z.Z. Chong   +138 more
core   +2 more sources

Regulation of the endosomal SNX27-retromer by OTULIN

Nature Communications, 2019
OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 ...
Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander, Daniel Krappmann   +12 more
doaj   +1 more source

On the fate of early endosomes [PDF]

, 2017
Proteins are endocytosed by various pathways into the cell. All these pathways converge at the level of the early endosome. The fate of the early endosome and how proteins are sorted into recycling and late endosomes/multi-vesicular body is a matter of ...
Spang, Anne
core  

The possible impact of sortilin in reducing HBsAg expression in chronic hepatitis B [PDF]

, 2016
Hepatitis B virus (HBV) infection is a major global health problem. Chronically infected people are at risk for progressive hepatic fibrosis and consequent cirrhosis.
Besharat, S., Darvishi, Z., Katoonizadeh, A., Mohamadkhani, A., Moossavi, S., Poustchi, H., Roshandel, G.   +6 more
core  

OXR1 maintains the retromer to delay brain aging under dietary restriction

Nature Communications
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR.
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi   +23 more
doaj   +1 more source

Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface

Computational and Structural Biotechnology Journal
The stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic ...
Elisa Fagnani, Francesco Bonì, Pierfausto Seneci, Davide Gornati, Luca Muzio, Eloise Mastrangelo, Mario Milani   +6 more
doaj   +1 more source

VPS35 and retromer dysfunction in Parkinson's disease

Philosophical Transactions of the Royal Society B: Biological Sciences
The vacuolar protein sorting 35 ortholog ( VPS35 ) gene encodes a core component of the retromer complex essential for the endosomal sorting and recycling of transmembrane cargo. Endo-lysosomal pathway deficits are suggested to play a role in the pathogenesis of neurodegenerative diseases ...
Jordan Rowlands, Darren J. Moore
openaire   +2 more sources

Retromer-dependent lysosomal stress in Parkinson's disease

Philosophical Transactions of the Royal Society B: Biological Sciences
While causative mutations in complex disorders are rare, they can be used to extract a biological pathway whose pathogenicity can generalize to common forms of the disease. Here we begin by relying on the biological consequences of mutations in LRRK2 and VPS35, genetic causes of autosomal-dominant Parkinson's disease, to hypothesize that ‘Retromer ...
Dario R. Alessi, Peter J. Cullen, Mark Cookson, Kalpana M. Merchant, Scott A. Small   +4 more
openaire   +3 more sources