Results 131 to 140 of about 11,758 (252)
PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly
Cell Reports, 2017 Summary: The tumor suppressor PTEN executes cellular functions predominantly through its phosphatase activity. Here we identified a phosphatase-independent role for PTEN during vesicular trafficking of the glucose transporter GLUT1.
Swapnil Rohidas Shinde +1 more
doaj +1 more source
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease [PDF]
, 2016 Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing ...
Andresen, Thomas Lars +10 more
core +2 more sources
Endocrinology and the brain: Corticotropin-Releasing Hormone signaling [PDF]
, 2017 Corticotropin-releasing hormone (CRH) is a key player of basal and stress activated responses in the hypothalamic-pituitary-adrenal axis (HPA) and in extrahypothalamic circuits, where it functions as a neuromodulator to orchestrate humoral and behavioral
Armando, Natalia Giannina +3 more
core +2 more sources
The Journal of Physiology, Volume 603, Issue 22, Page 6921-6947, November 15, 2025.Abstract figure legend Nhe6 knockout mice (lower right) show age‐dependent weight loss resulting from lower fat accumulation in adipocytes, similar to Christianson's syndrome patients with NHE6 loss of function mutations. NHE6 is a Na+/H+ exchanger that regulates endosomal pH (pHendo) required for delivery of cargo, including fat and glucose ...
Ruby Gupta +7 more
wiley +1 more source
Phosphorylation on serine 72 modulates Rab7A palmitoylation and retromer recruitment.
J Cell SciThe small GTPase Rab7A has a key role in regulating membrane trafficking at late endosomes. By interacting with several different effectors, this small GTPase controls late endosome mobility, orchestrates fusion events between late endosomes and ...
Modica G +6 more
europepmc +2 more sources
Functional coupling of microtubules to membranes - implications for membrane structure and dynamics [PDF]
, 2012 The microtubule network dictates much of the spatial patterning of the cytoplasm, and the coupling of microtubules to membranes controls the structure and positioning of organelles and directs membrane trafficking between them.
Stephens, David J
core +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.ABSTRACT Background Muscle RING finger (MuRF) proteins are striated muscle‐specific E3 ubiquitin ligases essential for muscle homeostasis. Whereas MuRF1 is well known for its role in muscle atrophy, MuRF2 and MuRF3 contribute to microtubule stabilization, influencing muscle differentiation and function.
Ning Li +13 more
wiley +1 more source
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor. [PDF]
, 2016 Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ...
Benovic, Jeffrey L. +6 more
core +2 more sources
Nature Communications, 2016 The retromer complex is a multi-protein component of the endosomal protein sorting machinery. Here, Sangaré et al. identify unique features in the retromer complex of the parasite Toxoplasma gondii, and show that it is crucial for the biogenesis of ...
Lamba Omar Sangaré +12 more
doaj +1 more source
Sortilin is associated with the chlamydial inclusion and is modulated during infection [PDF]
, 2016 © 2016. Published by The Company of Biologists Ltd. Chlamydia species are obligate intracellular pathogens that have a major impact on human health. The pathogen replicates within an intracellular niche called an inclusion and is thought to rely heavily ...
Huston, WM +3 more
core +1 more source