Results 151 to 160 of about 11,758 (252)

The retromer and retriever systems are conserved and differentially expanded in parabasalids

Journal of Cell Science
Early endosomes sort transmembrane cargo either for lysosomal degradation or retrieval to the plasma membrane or the Golgi complex. Endosomal retrieval in eukaryotes is governed by the anciently homologous retromer or retriever complexes.
A. Shinde, Jitka Kučerová, J. Dacks, Jan Tachezy   +3 more
semanticscholar   +1 more source

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

Nature Communications, 2018
Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C.
Ian J. McGough, Reinoud E. A. de Groot, Adam P. Jellett, Marco C. Betist, Katherine C. Varandas, Chris M. Danson, Kate J. Heesom, Hendrik C. Korswagen, Peter J. Cullen   +8 more
doaj   +1 more source

Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. [PDF]

, 2012
Despite recent advances in mass spectrometry, proteomic characterization of transport vesicles remains challenging. Here, we describe a multivariate proteomics approach to analyzing clathrin-coated vesicles (CCVs) from HeLa cells. siRNA knockdown of coat
Abou Jamra, Antrobus, Bergeron, Blondeau, Booth, Borner, Burgos, Chekulaeva, Cheng, Cole, Cox, Daniela A. Sahlender, Dell’Angelica, Dergai, Drenckhahn, Dunkley, Eisenberg, Field, Gary S. Bhumbra, Georg H.H. Borner, Girard, Hall, Hirst, Hirst, Hirst, Hirst, Hubner, Ishihama, Janes, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, McGough, McPherson, Miller, Moreno-De-Luca, Newmyer, Ohta, Ong, Patrycja Kozik, Robin Antrobus, Robinson, Robinson, Royle, Schneider, Schröder, Seaman, Shimizu, Simpson, Stenmark, Tanenbaum, Tiwari, Traub, Verkerk, Yoshimura   +54 more
core   +1 more source

Evidence for a Golgi-to-endosome protein sorting pathway in Plasmodium falciparum.

PLoS ONE, 2014
During the asexual intraerythrocytic stage, the malaria parasite Plasmodium falciparum must traffic newly-synthesized proteins to a broad array of destinations within and beyond the parasite's plasma membrane.
Priscilla Krai, Seema Dalal, Michael Klemba   +2 more
doaj   +1 more source

Mapping the endosomal proximity proteome reveals Retromer as a hub for RAB GTPase regulation

bioRxiv
Endosomal retrieval and recycling of integral cargo proteins is essential for cell, tissue and organism-level development and homeostasis and is orchestrated through a specialised retrieval sub-domain on the endosomal vacuole.
Antón-Plágaro C, Chen K, Guo Q, Liu M, Evans AJ, Lewis PA, Heesom KJ, Wilkinson KA, Collins BM, Cullen PJ.   +9 more
europepmc   +2 more sources

P4-ATPase endosomal recycling relies on multiple retromer-dependent localization signals. [PDF]

Mol Biol Cell
Type IV P-type ATPases (P4-ATPases) are lipid flippases that generate an asymmetric membrane organization essential for cell viability. The five budding yeast P4-ATPases traffic between the Golgi complex, plasma membrane, and endosomes but how they are ...
Jiménez M, Kyoung CK, Nabukhotna K, Watkins D, Jain BK, Best JT, Graham TR.   +6 more
europepmc   +2 more sources

On the fate of early endosomes [PDF]

, 2017
Proteins are endocytosed by various pathways into the cell. All these pathways converge at the level of the early endosome. The fate of the early endosome and how proteins are sorted into recycling and late endosomes/multi-vesicular body is a matter of ...
Spang, Anne
core  

A therapeutic roadmap to restore the SORL1‐retromer recycling complex [PDF]

Alzheimers Dement
Genetic, cell biology and autopsied brain tissue studies indicate that deficits in the SORL1‐retromer complex play a critical role in the pathogenesis of Alzheimer’s disease (AD).
Merchant K.
europepmc   +2 more sources

EhVps35, a retromer component, is involved in the recycling of the EhADH and Gal/GalNac virulent proteins of Entamoeba histolytica

Frontiers in Parasitology
The retromer is a highly conserved eukaryotic complex formed by the cargo selective complex (CSC) and the sorting nexin (SNX) dimer subcomplexes. Its function is protein recycling and recovery from the endosomes to conduct the target molecules to the ...
Joselin Díaz-Valdez, R. Javier‐Reyna, S. Montaño, Daniel Talamás-Lara, Esther Orozco   +4 more
semanticscholar   +1 more source

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network [PDF]

, 2007
Tatyana Y. Belenkaya, Yihui Wu, Xiaofang Tang, Bo Zhou, L Cheng, Yagya V. Sharma, Yan Dong, Erica M. Selva, Xinhua Lin   +8 more
openalex   +1 more source