Results 11 to 20 of about 11,758 (252)
Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function [PDF]
eLifeATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number of biological outputs includes control of tuberculosis in animal models.
Masroor Ahmad Paddar +11 more
doaj +4 more sources
The Sorting and Transport of the Cargo Protein CcSnc1 by the Retromer Complex Regulate the Growth, Development, and Pathogenicity of Corynespora cassiicola [PDF]
Journal of FungiIn eukaryotes, the retromer complex is critical for the transport of cargo proteins from endosomes to the trans-Golgi network (TGN). Despite its importance, there is a lack of research on the retromer-mediated transport of cargo proteins regulating the ...
Shuyuan Cheng +10 more
doaj +3 more sources
Retromer promotes the lysosomal turnover of mtDNA. [PDF]
Sci AdvMitochondrial DNA (mtDNA) is exposed to multiple insults produced by normal cellular function. Upon mtDNA replication stress, the mitochondrial genome transfers to endosomes for degradation. Using proximity biotinylation, we found that mtDNA stress leads
Kakanj P +10 more
europepmc +4 more sources
γ-secretase facilitates retromer-mediated retrograde transport.
J Cell SciRetromer mediates retrograde transport of protein cargoes from endosomes to the trans-Golgi network (TGN). γ-secretase is a protease that cleaves the transmembrane domain of its target proteins.
Takeo Y, Crite M, Mehmood K, DiMaio D.
europepmc +7 more sources
Retromer in Synaptic Function and Pathology [PDF]
Frontiers in Synaptic Neuroscience, 2018 The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network (TGN) or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including ...
Lennart Brodin +2 more
doaj +3 more sources
Retromer disruption promotes amyloidogenic APP processing [PDF]
Neurobiology of Disease, 2011 Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in ...
Christopher P. Sullivan +7 more
doaj +3 more sources
Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. [PDF]
Proc Natl Acad Sci U S AEndosomal membrane trafficking is mediated by specific protein coats and formation of actin-rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27–Retromer assembly interacts with ...
Guo Q +10 more
europepmc +3 more sources
Current Opinion in Cell Biology, 2008 The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition
Juan S. Bonifacino, James H. Hurley
+9 more sources
The emerging role of retromer in neuroprotection [PDF]
Current Opinion in Cell Biology, 2017 Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism ...
Cullen, Peter J +2 more
core +9 more sources
Dysregulation of SNX1-retromer axis in pharmacogenetic models of Parkinson’s disease
Cell Death DiscoverySince the identification of vacuolar protein sorting (VPS) 35, as a causative molecule for familial Parkinson’s disease (PD), retromer-mediated endosomal machinery has been a rising factor in the pathogenesis of the disease.
Shun Yoshida +9 more
doaj +2 more sources