Results 11 to 20 of about 9,787 (196)
Retromer in Synaptic Function and Pathology [PDF]
Frontiers in Synaptic Neuroscience, 2018 The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network (TGN) or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including ...
Lennart Brodin +2 more
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Retromer disruption promotes amyloidogenic APP processing [PDF]
Neurobiology of Disease, 2011 Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in ...
Christopher P. Sullivan +7 more
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The emerging role of retromer in neuroprotection [PDF]
Current Opinion in Cell Biology, 2017 Efficient sorting and transportation of integral membrane proteins, such as ion channels, nutrient transporters, signalling receptors, cell-cell and cell-matrix adhesion molecules is essential for the function of cellular organelles and hence organism ...
Cullen, Peter J +2 more
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Current Opinion in Cell Biology, 2008 The retromer is a heteropentameric complex that associates with the cytosolic face of endosomes and mediates retrograde transport of transmembrane cargo from endosomes to the trans-Golgi network. The mammalian retromer complex comprises a sorting nexin dimer composed of a still undefined combination of SNX1, SNX2, SNX5 and SNX6, and a cargo-recognition
Juan S, Bonifacino, James H, Hurley
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Current Biology, 2017 Lucas and Hierro introduce the retromer and its role in endosomal protein sorting and trafficking.
María, Lucas, Aitor, Hierro
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Retromer complex proteins are decreased in Down syndrome (DS) brains and correlate inversely with brain amyloidosis. However, whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of DS remains unknown ...
Mary Elizabeth Curtis +3 more
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Retromers in Alzheimer’s Disease [PDF]
Neurodegenerative Diseases, 2012 Amyloid-β peptide (Aβ), the key pathogenic agent in Alzheimer’s disease (AD), is released after sequential proteolytic cleavage of the transmembrane amyloid precursor protein (APP). β-Site APP-cleaving enzyme 1 (BACE1) cleaves APP in early endosomes, and the cause of increased BACE cleavage of APP in AD is not fully resolved yet.
Siegenthaler, Barbara +1 more
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Retromer revisited: Evolving roles for retromer in endosomal sorting [PDF]
Journal of Cell Biology, 2017 The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol.
John P. Chamberland, Brigitte Ritter
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Going Forward with Retromer [PDF]
Developmental Cell, 2014 The retromer complex is well known to mediate retrograde transport from endosomes to the Golgi. In a recent issue of Neuron, Choy et al. (2014) identify a function for retromer in supporting fast, local delivery of neurotransmitter receptors from endosomes to the dendritic plasma membrane.
Farias, Ginny G. +2 more
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Understanding the contributions of VPS35 and the retromer in neurodegenerative disease
Neurobiology of Disease, 2022 Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD).
Erin T. Williams +3 more
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