Results 21 to 30 of about 9,787 (196)
eLife, 2020 Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye +10 more
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Membrane-associated proteins in giardia lamblia [PDF]
, 2018 The manner in which membrane-associated proteins interact with the membrane defines their subcellular fate and function. This interaction relies on the characteristics of the proteins, their journey after synthesis, and their interaction with other ...
Feliziani, Constanza +2 more
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Cellular processes associated with LRRK2 function and dysfunction. [PDF]
, 2015 Mutations in the leucine-rich repeat kinase 2 (LRRK2) encoding gene are the most common cause of monogenic Parkinson's Disease (PD). The identification of LRRK2 polymorphisms associated with increased risk for sporadic PD, as well as the observation that
Bandopadhyay, R, Manzoni, C, Wallings, R
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Retromer Retrieves Wntless [PDF]
Developmental Cell, 2008 Wntless is a sorting receptor required for Wnt secretion. Wntless is retrieved from endosomes to the Golgi by retromer, permitting Wntless reutilization in Wnt transport. In the absence of retromer, Wntless is degraded in lysosomes and Wnt secretion is impaired.
openaire +3 more sources
Navigating the Controversies of Retromer-Mediated Endosomal Protein Sorting
Frontiers in Cell and Developmental Biology, 2021 The retromer complex was first identified more than 20 years ago through studies conducted in the yeast Saccharomyces cerevisiae. Data obtained using many different model systems have revealed that retromer is a key component of the endosomal protein ...
Yingfeng Tu, Matthew N. J. Seaman
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Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour [PDF]
, 2016 The five-subunit WASH complex generates actin networks that participate in endocytic trafficking, migration and invasion in various cell types. Loss of one of the two subunits WASH or strumpellin in mice is lethal, but little is known about their role in
Insall, Robert H. +5 more
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Complex polarity: building multicellular tissues through apical membrane traffic [PDF]
, 2016 The formation of distinct subdomains of the cell surface is crucial for multicellular organism development. The most striking example of this is apical-basal polarization.
Adams +157 more
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Retromer dysfunction in amyotrophic lateral sclerosis
Proceedings of the National Academy of Sciences, 2022 Retromer is a heteropentameric complex that plays a specialized role in endosomal protein sorting and trafficking. Here, we report a reduction in the retromer proteins—vacuolar protein sorting 35 (VPS35), VPS26A, and VPS29—in patients with amyotrophic lateral sclerosis (ALS) and in the ALS model provided by transgenic (Tg) mice expressing ...
Eduardo J. Pérez-Torres +87 more
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Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
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The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2018 The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s ...
Hongfeng Zhang +8 more
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