Results 21 to 30 of about 11,758 (252)

VPS35 and retromer dysfunction in Parkinson's disease

Philosophical Transactions of the Royal Society B: Biological Sciences
The vacuolar protein sorting 35 ortholog (VPS35) gene encodes a core component of the retromer complex essential for the endosomal sorting and recycling of transmembrane cargo.
Jordan Rowlands, Darren J. Moore
semanticscholar   +3 more sources

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition. [PDF]

Proc Natl Acad Sci U S A
Significance The endosomal–lysosomal network is essential for normal cellular function with network defects being associated with numerous neurodegenerative diseases.
Daly JL, Chen KE, Butkovič R, Guo Q, Healy MD, Pennink E, Gamble-Strutt G, Higham Z, Moody ERR, Lewis PA, Heesom KJ, Williams TA, McMillan KJ, Collins BM, Cullen PJ.   +14 more
europepmc   +4 more sources

OXR1 maintains the retromer to delay brain aging under dietary restriction

Nature Communications
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR.
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi   +23 more
doaj   +2 more sources

Retromer-dependent lysosomal stress in Parkinson's disease

Philosophical Transactions of the Royal Society B: Biological Sciences
While causative mutations in complex disorders are rare, they can be used to extract a biological pathway whose pathogenicity can generalize to common forms of the disease. Here we begin by relying on the biological consequences of mutations in LRRK2 and
Dario R. Alessi, Peter J. Cullen, Mark R. Cookson, Kalpana Merchant, Scott A. Small   +4 more
semanticscholar   +4 more sources

LEAP2 triggers retromer-mediated membrane trafficking of MOSPD2 to promote chemotaxis in teleost monocytes/macrophages. [PDF]

Zool Res
Liver-expressed antimicrobial peptide 2 (LEAP2) is a key regulator of innate immune defense in teleosts, yet the molecular basis of its chemotactic function remains largely unidentified.
Zhu TF, Zhao ZY, Fei CJ, Shen SC, Shao JZ, Nie L, Chen J.   +6 more
europepmc   +2 more sources

Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2022
Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby ...
Shun Yoshida, Shun Yoshida, Takafumi Hasegawa   +2 more
doaj   +1 more source

Erratum for the Research Article: "Targeting VPS18 hampers retromer trafficking of PD-L1 and augments immunotherapy" by T. Dong <i>et al</i>.

Sci Adv
europepmc   +2 more sources

ER stress disrupts insulin release in murine models of type 2 diabetes by impairing retromer action and constitutive secretion

Cell Reports
Nancy Sue, Le May Thai, Ebru Boslem, Kwan Yi Chu, Chenxu Yan, Leanne Mackin, William E. Hughes, Angela Fontaine-Titley, Deborah S. Barkauskas, Louise Cottle, Helen E. Thomas, Carsten Schmitz‐Peiffer, Yan‐Chuan Shi, Paul Timpson, David Herrmann, Martin Whitham, Trevor J. Biden   +16 more
openalex   +3 more sources

Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. [PDF]

PLoS Pathogens, 2015
Trafficking of human papillomaviruses to the Golgi apparatus during virus entry requires retromer, an endosomal coat protein complex that mediates the vesicular transport of cellular transmembrane proteins from the endosome to the Golgi apparatus or the ...
Andreea Popa, Wei Zhang, Megan S Harrison, Kylia Goodner, Teymur Kazakov, Edward C Goodwin, Alex Lipovsky, Christopher G Burd, Daniel DiMaio   +8 more
doaj   +1 more source

VPS35-Retromer: Multifunctional Roles in Various Biological Processes - A Focus on Neurodegenerative Diseases and Cancer. [PDF]

J Inflamm Res
The Vacuolar Protein Sorting 35 (VPS35)-Retromer complex plays a pivotal role in intracellular protein trafficking and recycling. As an integral component of the Retromer complex, VPS35 selectively recognizes and retrogradely transports membrane protein ...
Fan X, Xie Y, Cao S, Zhu L, Wang X.
europepmc   +2 more sources