Mistargeting of secretory cargo in retromer-deficient cells
Disease Models & Mechanisms, 2021 Intracellular trafficking is a basic and essential cellular function required for delivery of proteins to the appropriate subcellular destination; this process is especially demanding in professional secretory cells, which synthesize and secrete massive ...
Sarah D. Neuman +4 more
doaj +1 more source
Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation [PDF]
, 2016 Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate ...
Ariotti, Nicholas +7 more
core +1 more source
PLoS Pathogens, 2023 Rab GTPases play key roles in controlling intracellular vesicular transport. GTP-bound Rab proteins support vesicle trafficking. Here, we report that, unlike cellular protein cargos, retromer-mediated delivery of human papillomaviruses (HPV) into the ...
Jeongjoon Choi, Daniel DiMaio
doaj +1 more source
The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
core +2 more sources
Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]
, 2013 Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska +54 more
core +4 more sources
Multifaceted Roles of Retromer in EGFR Trafficking and Signaling Activation
Cells, 2022 Mammalian retromer complex contributes to multiple early endosome-associated trafficking pathways whose origins are dependent on which sorting nexin (SNX) they are complexed with.
Zhe Yang +3 more
doaj +1 more source
WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]
, 2015 Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T +6 more
core +1 more source
Endosomal Sorting: Architecture of the Retromer Coat [PDF]
Current Biology, 2018 Retromer is a master regulator of endosomal cargo sorting. Using cryo-EM, a new study now reveals how, in yeast, this multiprotein complex is assembled on tubular membranes to form a coat complex that orchestrates the process of tubular-based cargo sorting.
Simonetti, Boris, Cullen, Pete
openaire +4 more sources
Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50 [PDF]
, 2016 Retromer and the associated actin-polymerizing WASH complex are essential for the endocytic recycling of a wide range of integral membrane proteins. A hereditary Parkinson's-disease-causing point mutation (D620N) in the retromer subunit VPS35 perturbs
Cullen, Peter J. +7 more
core +2 more sources
Endosomal receptor trafficking: Retromer and beyond [PDF]
Traffic, 2018 The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome‐to‐Golgi receptor recycling, mammalian retromer has emerged as a central ...
Jing Wang +5 more
openaire +3 more sources