Results 31 to 40 of about 11,758 (252)
Current Biology, 2017 Lucas and Hierro introduce the retromer and its role in endosomal protein sorting and trafficking.
María, Lucas, Aitor, Hierro
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Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling [PDF]
Plant Cell ReportsRetromer protein AtVPS29 upregulates the SLY1 protein and downregulates the RGA protein, positively stimulating the development of the root meristematic zone, which indicates an important role of AtVPS29 in gibberellin signaling.
Wang Ki Min +3 more
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Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Retromer complex proteins are decreased in Down syndrome (DS) brains and correlate inversely with brain amyloidosis. However, whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of DS remains unknown ...
Mary Elizabeth Curtis +3 more
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Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation. [PDF]
Nat CommunEndosomal retrieval and recycling of integral cargo proteins is essential for cell and organism development and homeostasis and is orchestrated through a specialised endosomal nanodomain, the retrieval sub-domain.
Antón-Plágaro C +9 more
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Retromer enhancement rescues endosomal recycling defects induced by SORL1 deficiency [PDF]
Alzheimers DementMishra S, Williams C, Young J.
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Retromers in Alzheimer’s Disease [PDF]
Neurodegenerative Diseases, 2012 Amyloid-β peptide (Aβ), the key pathogenic agent in Alzheimer’s disease (AD), is released after sequential proteolytic cleavage of the transmembrane amyloid precursor protein (APP). β-Site APP-cleaving enzyme 1 (BACE1) cleaves APP in early endosomes, and the cause of increased BACE cleavage of APP in AD is not fully resolved yet.
Siegenthaler, Barbara +1 more
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Retromer revisited: Evolving roles for retromer in endosomal sorting [PDF]
Journal of Cell Biology, 2017 The highly conserved retromer complex has been linked to cargo retrieval from endosomes to the trans-Golgi network. In this issue, Kvainickas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702137) and Simonetti et al. (2017. J. Cell Biol.
John P. Chamberland, Brigitte Ritter
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eLife, 2020 Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye +10 more
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Going Forward with Retromer [PDF]
Developmental Cell, 2014 The retromer complex is well known to mediate retrograde transport from endosomes to the Golgi. In a recent issue of Neuron, Choy et al. (2014) identify a function for retromer in supporting fast, local delivery of neurotransmitter receptors from endosomes to the dendritic plasma membrane.
Farias, Ginny G. +2 more
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Understanding the contributions of VPS35 and the retromer in neurodegenerative disease
Neurobiology of Disease, 2022 Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD).
Erin T. Williams +3 more
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