A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit
eLife, 2017 We describe a regulatory mechanism that controls the activity of retromer, an evolutionarily conserved sorting device that orchestrates cargo export from the endosome.
Tie-Zhong Cui +2 more
doaj +1 more source
Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease
Frontiers in Cell and Developmental Biology, 2021 Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of cellular sorting processes and can drive severe physiological outcomes.
Mintu Chandra +6 more
doaj +1 more source
Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]
, 2018 The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Arighi +30 more
core +1 more source
Modulation of plant autophagy during pathogen attack [PDF]
, 2017 In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O. +9 more
core +1 more source
Role of Retromer Complex in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2016 Retromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders.
Li eChaosi +3 more
doaj +1 more source
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing [PDF]
, 2018 The processing of amyloid precursor protein (APP) to the neurotoxic pro-aggregatory Aβ peptide is controlled by the mechanisms that govern the trafficking and localisation of APP.
Breusegem, Sophia +2 more
core +1 more source
Diversity of retromer-mediated vesicular trafficking pathways in plants
Frontiers in Plant Science, 2023 The plant endomembrane system is organized and regulated by large gene families that encode proteins responsible for the spatiotemporal delivery and retrieval of cargo throughout the cell and to and from the plasma membrane.
Suryatapa Ghosh Jha, Emily R. Larson
doaj +1 more source
Retromer promotes the lysosomal turnover of mtDNA. [PDF]
Sci AdvMitochondrial DNA (mtDNA) is exposed to multiple insults produced by normal cellular function. Upon mtDNA replication stress, the mitochondrial genome transfers to endosomes for degradation. Using proximity biotinylation, we found that mtDNA stress leads to the rewiring of the mitochondrial proximity proteome, increasing mitochondria’s ...
Kakanj P +10 more
europepmc +3 more sources
Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated [PDF]
, 2010 Background Retrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5-containing endosomes, mediated by clathrin and the recently characterized retromer complex.
Edgar F da Cruz e Silva +9 more
core +2 more sources
Signalling gets sorted by retromer [PDF]
The EMBO Journal, 2011 Wnt proteins are secreted glycoproteins required for intercellular communication and important for development and tissue homoeostasis. Wnts are secreted through association to the sorting receptor Wntless, which promotes transport of Wnt from the trans‐Golgi network (TGN) to the plasma membrane.
openaire +4 more sources