Results 51 to 60 of about 11,758 (252)

The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2018
The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s ...
Hongfeng Zhang, Timothy Huang, Yujuan Hong, Weijie Yang, Xian Zhang, Hong Luo, Huaxi Xu, Huaxi Xu, Xin Wang   +8 more
doaj   +1 more source

Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease

Frontiers in Cell and Developmental Biology, 2021
Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of cellular sorting processes and can drive severe physiological outcomes.
Mintu Chandra, Mintu Chandra, Amy K. Kendall, Amy K. Kendall, Lauren P. Jackson, Lauren P. Jackson, Lauren P. Jackson   +6 more
doaj   +1 more source

Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation [PDF]

, 2016
Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate ...
Ariotti, Nicholas, Bugarcic, Andrea, Collins, Brett M., Follett, Jordan, Norwood, Suzanne J., Parton, Robert G., Teasdale, Rohan D., Yang, Zhe   +7 more
core   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +4 more sources

WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway [PDF]

, 2015
Stress exposure triggers ligand-independent EGF receptor (EGFR) endocytosis, but its post-endocytic fate and role in regulating signalling are unclear. We show that the p38 MAP kinase-dependent, EGFR tyrosine kinase (TK)-independent EGFR internalization ...
Burgoyne, T, Futter, CE, Hartley, JA, Hochhauser, D, Sorkin, A, Tomas, A, Vaughan, SO   +6 more
core   +1 more source

Noncanonical Rab9a action supports retromer-mediated endosomal exit of human papillomavirus during virus entry.

PLoS Pathogens, 2023
Rab GTPases play key roles in controlling intracellular vesicular transport. GTP-bound Rab proteins support vesicle trafficking. Here, we report that, unlike cellular protein cargos, retromer-mediated delivery of human papillomaviruses (HPV) into the ...
Jeongjoon Choi, Daniel DiMaio
doaj   +1 more source

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]

, 2008
Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric, Ganley, Ian G., Pfeffer, Suzanne R.   +2 more
core   +4 more sources

Endosomal Sorting: Architecture of the Retromer Coat [PDF]

Current Biology, 2018
Retromer is a master regulator of endosomal cargo sorting. Using cryo-EM, a new study now reveals how, in yeast, this multiprotein complex is assembled on tubular membranes to form a coat complex that orchestrates the process of tubular-based cargo sorting.
Simonetti, Boris, Cullen, Pete
openaire   +4 more sources

Multifaceted Roles of Retromer in EGFR Trafficking and Signaling Activation

Cells, 2022
Mammalian retromer complex contributes to multiple early endosome-associated trafficking pathways whose origins are dependent on which sorting nexin (SNX) they are complexed with.
Zhe Yang, Zhengyang Feng, Zebin Li, Rohan D. Teasdale   +3 more
doaj   +1 more source

Correction to "From Mitochondria to Immunity: The Emerging Roles of Mitochondria-Derived Vesicles and Small Extracellular Vesicles in Cellular Communication and Disease". [PDF]

J Extracell Vesicles
Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.
europepmc   +2 more sources