Results 61 to 70 of about 9,787 (196)
The retromer complex in development and disease [PDF]
Development, 2015 The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes.
Shiuan, Wang, Hugo J, Bellen
openaire +2 more sources
Neurobiology of Disease, 2012 The retromer complex plays an important role in intracellular transport, is highly expressed in the hippocampus, and has been implicated in the trafficking of the amyloid precursor protein (APP).
Akhil Bhalla +5 more
doaj +1 more source
Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. [PDF]
, 2015 Notch signaling is a major regulator of cell fate, proliferation, and differentiation. Like other signaling pathways, its activity is strongly influenced by intracellular trafficking.
Bray, Sarah J +4 more
core +1 more source
PLoS Biology, 2014 Rhodopsin mistrafficking can cause photoreceptor (PR) degeneration. Upon light exposure, activated rhodopsin 1 (Rh1) in Drosophila PRs is internalized via endocytosis and degraded in lysosomes. Whether internalized Rh1 can be recycled is unknown.
Shiuan Wang +14 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts.
Lin Cui +11 more
doaj +1 more source
HTLV-1 Tax-1 interacts with SNX27 to regulate cellular localization of the HTLV-1 receptor molecule, GLUT1 [PDF]
, 2019 An estimated 10–20 million people worldwide are infected with human T cell leukemia virus type 1 (HTLV-1), with endemic areas of infection in Japan, Australia, the Caribbean, and Africa.
Al-Saleem, Jacob +6 more
core +3 more sources
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Membrane transport: Retromer to the rescue [PDF]
Current Biology, 2001 Genetic analysis in yeast has led to the discovery of a complex that retrieves proteins selectively from the prevacuolar compartment and transports them to the Golgi. Orthologs of these proteins in mammalian cells are likely to play a similar role but their cargoes are yet to be identified.
openaire +2 more sources
Retromer dysfunction at the nexus of tauopathies
Cell Death & Differentiation, 2021 Tauopathies define a broad range of neurodegenerative diseases that encompass pathological aggregation of the microtubule-associated protein tau. Although tau aggregation is a central feature of these diseases, their underlying pathobiology is remarkably heterogeneous at the molecular level.
Julian M. Carosi +3 more
openaire +5 more sources
Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus.
PLoS Genetics, 2015 The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-Golgi network in eukaryotes. However, the role of such trafficking events during pathogen-host interaction remains unclear.
Wenhui Zheng +15 more
doaj +1 more source