Retromer and the cation-independent mannose 6-phosphate receptor-Time for a trial separation? [PDF]
, 2018 The retromer cargo-selective complex (CSC) comprising Vps35, Vps29 and Vps26 mediates the endosome-to-Golgi retrieval of the cation-independent mannose 6-phosphate receptor (CIMPR). Or does it? Recently published data have questioned the validity of this
Arighi +30 more
core +1 more source
Endosomal receptor trafficking: Retromer and beyond [PDF]
Traffic, 2018 The tubular endolysosomal network is a quality control system that ensures the proper delivery of internalized receptors to specific subcellular destinations in order to maintain cellular homeostasis. Although retromer was originally described in yeast as a regulator of endosome‐to‐Golgi receptor recycling, mammalian retromer has emerged as a central ...
Jing Wang +5 more
openaire +3 more sources
A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit
eLife, 2017 We describe a regulatory mechanism that controls the activity of retromer, an evolutionarily conserved sorting device that orchestrates cargo export from the endosome.
Tie-Zhong Cui +2 more
doaj +1 more source
Reduced LRRK2 in association with retromer dysfunction in post-mortem brain tissue from LRRK2 mutation carriers [PDF]
, 2017 Missense mutations in leucine-rich repeat kinase 2 (LRRK2) are pathogenic for familial Parkinson's disease. However, it is unknown whether levels of LRRK2 protein in the brain are altered in patients with LRRK2-associated Parkinson's disease.
Dzamko, N +12 more
core +1 more source
The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie, Stephens, DJ
core +2 more sources
Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.
PLoS Pathogens, 2014 The envelope glycoprotein (Env) of the Human Immunodeficiency Virus Type-1 (HIV-1) is a critical determinant of viral infectivity, tropism and is the main target for humoral immunity; however, little is known about the cellular machinery that directs Env
Elisabetta Groppelli +3 more
doaj +1 more source
Role of Retromer Complex in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2016 Retromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders.
Li eChaosi +3 more
doaj +1 more source
Nature Communications, 2023 Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network.
James L. Daly +13 more
doaj +1 more source
Diversity of retromer-mediated vesicular trafficking pathways in plants
Frontiers in Plant Science, 2023 The plant endomembrane system is organized and regulated by large gene families that encode proteins responsible for the spatiotemporal delivery and retrieval of cargo throughout the cell and to and from the plasma membrane.
Suryatapa Ghosh Jha, Emily R. Larson
doaj +1 more source
Retromer protein VPS29 plays a crucial and positive role in the sumoylation system mediated by E3 SUMO ligase SIZ1. [PDF]
Plant JSUMMARY Vacuolar protein sorting 29 (VPS29) functions in retrograde protein transport as a component of the retromer complex. However, the role of VPS29 in the regulation of post‐translational modifications, such as sumoylation and ubiquitination, has ...
Min WK +11 more
europepmc +2 more sources