Dysfunction of the retromer complex system contributes to amyloid and tau pathology in a stem cell model of Down syndrome [PDF]
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Retromer complex proteins are decreased in Down syndrome (DS) brains and correlate inversely with brain amyloidosis. However, whether retromer dysfunction contributes to the amyloid beta (Aβ) and tau neuropathology of DS remains unknown ...
Mary Elizabeth Curtis +3 more
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The Sorting and Transport of the Cargo Protein CcSnc1 by the Retromer Complex Regulate the Growth, Development, and Pathogenicity of Corynespora cassiicola [PDF]
Journal of FungiIn eukaryotes, the retromer complex is critical for the transport of cargo proteins from endosomes to the trans-Golgi network (TGN). Despite its importance, there is a lack of research on the retromer-mediated transport of cargo proteins regulating the ...
Shuyuan Cheng +10 more
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Dysregulation of the Retromer Complex in Brain Endothelial Cells Results in Accumulation of Phosphorylated Tau [PDF]
Journal of Inflammation Research, 2021 Alessia Filippone, Tiffany Smith, Domenico Pratico Alzheimer’s Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USACorrespondence: Domenico PraticoAlzheimer’s Center at Temple, Lewis Katz School of Medicine ...
Filippone A, Smith T, Pratico D
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Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response [PDF]
Cells, 2021 Sodium metabisulfite (Na2S2O5) is widely used as a preservative in the food and wine industry. However, it causes varying degrees of cellular damage to organisms.
Xuejiao Jin +8 more
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Stabilization of the retromer complex: Analysis of novel binding sites of bis-1,3-phenyl guanylhydrazone 2a to the VPS29/VPS35 interface [PDF]
Computational and Structural Biotechnology JournalThe stabilization of the retromer protein complex can be effective in the treatment of different neurological disorders. Following the identification of bis-1,3-phenyl guanylhydrazone 2a as an effective new compound for the treatment of amyotrophic ...
Elisa Fagnani +6 more
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Stabilizing the retromer complex rescues synaptic dysfunction and endosomal trafficking deficits in an Alzheimer’s disease mouse model [PDF]
Acta Neuropathologica CommunicationsDisruptions in synaptic transmission and plasticity are early hallmarks of Alzheimer’s disease (AD). Endosomal trafficking, mediated by the retromer complex, is essential for intracellular protein sorting, including the regulation of amyloid precursor ...
David Ramonet +2 more
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The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases [PDF]
Frontiers in Aging Neuroscience, 2018 The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s ...
Hongfeng Zhang +8 more
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Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer’s Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein [PDF]
Stem Cell Reports, 2018 Summary: Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer’s disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here,
Jessica E. Young +5 more
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VPS35, the Retromer Complex and Parkinson’s Disease [PDF]
Journal of Parkinson’s Disease, 2017 Mutations in the vacuolar protein sorting 35 ortholog ( VPS35 ) gene encoding a core component of the retromer complex, have recently emerged as a new cause of late-onset, autosomal dominant familial Parkinson’s disease (PD).
Erin T. Williams +2 more
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The retromer complex safeguards against neural progenitor-derived tumorigenesis by regulating Notch receptor trafficking [PDF]
eLife, 2018 The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious ...
Bo Li +6 more
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