Results 91 to 100 of about 7,439,285 (173)

Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography–Tandem Mass Spectrometry

Veterinary and Comparative Oncology, Volume 24, Issue 1, Page 128-139, March 2026.
ABSTRACT Mammary carcinomas are aggressive neoplasms and a significant cause of mortality in female cats. Despite surgical removal, feline mammary carcinoma (FMC) often recurs or metastasizes. Specific tumour biomarkers are necessary for early detection, prognosis and therapy selection.
Pruettha Aruvornlop, Sekkarin Ploypetch, Walasinee Sakcamduang, Sirintra Sirivisoot, Tanit Kasantikul, Sittiruk Roytrakul, Narumon Phaonakrop, Nlin Arya   +7 more
wiley   +1 more source

Xenopus Wntless and the Retromer Complex Cooperate To Regulate XWnt4 Secretion [PDF]

Molecular and Cellular Biology, 2009
Wnt signaling is implicated in a variety of developmental and pathological processes. The molecular mechanisms governing the secretion of Wnt ligands remain to be elucidated. Wntless, an evolutionarily conserved multipass transmembrane protein, is a dedicated secretion factor of Wnt proteins that participates in Drosophila melanogaster embryogenesis ...
Kim, H, Cheong, SM, Ryu, J, Jung, HJ, Jho, EH, Han, JK   +5 more
openaire   +3 more sources

Retromer Is Essential for Autophagy-Dependent Plant Infection by the Rice Blast Fungus.

PLoS Genetics, 2015
The retromer mediates protein trafficking through recycling cargo from endosomes to the trans-Golgi network in eukaryotes. However, the role of such trafficking events during pathogen-host interaction remains unclear.
Wenhui Zheng, Jie Zhou, Yunlong He, Qiurong Xie, Ahai Chen, Huawei Zheng, Lei Shi, Xu Zhao, Chengkang Zhang, Qingping Huang, Kunhai Fang, Guodong Lu, Daniel J Ebbole, Guangpu Li, Naweed I Naqvi, Zonghua Wang   +15 more
doaj   +1 more source

A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

Molecular Neurodegeneration, 2020
Background The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and
Jian-Guo Li, Jin Chiu, Mercy Ramanjulu, Benjamin E. Blass, Domenico Praticò   +4 more
doaj   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

A Robust Serum Proteomic Signature of the E2 Allele of Apolipoprotein E

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study expands a serum protein signature of the e2 allele of APOE using multiple proteomic platforms and UK Biobank replication. The signature supports the role of APOE in lipid regulation through apolipoproteins and inflammation and includes, among others, neutrophil secreted granule proteins CAMP, CTSG, DEFA3, and MPO that point to inhibition of ...
Paola Sebastiani, Eric Reed, Kevin B Chandler, Prisma Lopez, Hannah Lords, Harold Bae, Catherine E Costello, Matthew Au, Lingyi Lynn Deng, Mengze Li, Qingyan Xiang, Heeju Noh, Lance Pflieger, Cory Funk, Noa Rappaport, Marianne Nygaard, Meghan I Short, Michael Brent, Stefano Monti, Stacy L Andersen, Thomas T Perls   +20 more
wiley   +1 more source

Alzheimer's disease Stage 1 and 2: Biology, diagnostics, and treatment

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 1, January/March 2026.
Abstract Advances in biomarker technology, digital cognitive assessments, and amyloid‐targeting therapies have redefined the opportunities for accurate and early diagnosis and care of Alzheimer's disease (AD). These advances also create new possibilities for intervention before the onset of cognitive impairment.
Suzanne E. Schindler, Oskar Hansson, Alicia Algeciras‐Schimnich, Jalayne J. Arias, Brent Beasley, Gill Farrar, Nicole R. Fowler, Sarah M. Hartz, Clifford R. Jack, Linus Jönsson, Geoffrey Joyce, Claire J. Lansdall, Paul Maruff, Niklas Mattsson‐Carlgren, Catherine Jane Mummery, Jennifer Murphy, Hamid Okhravi, Ronald C. Petersen, Rema Raman, Christopher Randolph, Marie Reeberg Sass, Eric M. Reiman, Gemma Salvadó, Michael Schöll, Eric Siemers, Reisa A. Sperling, Tricia Thornton‐Wells, Rosanna Tortelli, Duygu Tosun, Lawren Vandevrede, Nicolas Villain, Stacie Weninger, Alette M. Wessels, Jin Zhou, Maria C. Carrillo, Christopher J. Weber   +35 more
wiley   +1 more source

Evolutionary reconstruction of the retromer complex and its function in Trypanosoma brucei [PDF]

Journal of Cell Science, 2011
Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde traffic from the endosome or lysosome to the Golgi complex. Here, comparative genomics, cell biology and phylogenetics were used to probe the early evolution of retromer and its function.
V Lila, Koumandou, Mary J, Klute, Emily K, Herman, Ricardo, Nunez-Miguel, Joel B, Dacks, Mark C, Field   +5 more
openaire   +2 more sources

Retromer dependent recycling of the Wnt secretion factor Wls is dispensable for stem cell maintenance in the mammalian intestinal epithelium. [PDF]

PLoS ONE, 2013
In C. elegans and Drosophila, retromer mediated retrograde transport of Wntless (Wls) from endosomes to the trans-Golgi network (TGN) is required for Wnt secretion.
Reinoud E A de Groot, Henner F Farin, Marie Macůrková, Johan H van Es, Hans C Clevers, Hendrik C Korswagen   +5 more
doaj   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, Volume 12, Issue 48, December 29, 2025.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source