Results 101 to 110 of about 7,439,285 (173)

Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2 [PDF]

Proceedings of the National Academy of Sciences, 2005
We have previously shown that the putative mammalian retromer components sorting nexins 1 and 2 ( Snx1 and Snx2 ) result in embryonic lethality when simultaneously targeted for deletion in mice, whereas others have shown that Hβ58 (also known as mVps26
Courtney T, Griffin, JoAnn, Trejo, Terry, Magnuson   +2 more
openaire   +2 more sources

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Structure of Vps26B and Mapping of its Interaction with the Retromer Protein Complex [PDF]

Traffic, 2007
Retromer is a heteromeric protein complex with important roles in endosomal membrane trafficking, most notably in the retrograde transport of lysosomal hydrolase receptors from endosomes to the Golgi. The core of retromer is composed of three subunits vacuolar protein sorting (Vps)35, Vps26 and Vps29, and in mammals, there are two paralogues of the ...
Brett M, Collins, Suzanne J, Norwood, Markus C, Kerr, Donna, Mahony, Matthew N J, Seaman, Rohan D, Teasdale, David J, Owen   +6 more
openaire   +3 more sources

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

Sorting Out the Role of α-Synuclein in Retromer-Mediated Endosomal Protein Sorting

Journal of Experimental Neuroscience, 2018
Retromer is a phylogenetically conserved, multisubunit coat complex that controls endosomal protein trafficking and sorting. Mutations in the retromer gene VPS35 cause late-onset Parkinson disease, suggesting that trafficking defects cause ...
Dhaval Patel, Stephan N Witt
doaj   +1 more source

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins.

PLoS ONE, 2011
VPS29 is a key component of the cargo-binding core complex of retromer, a protein assembly with diverse roles in transport of receptors within the endosomal system.
James D Swarbrick, Daniel J Shaw, Sandeep Chhabra, Rajesh Ghai, Eugene Valkov, Suzanne J Norwood, Matthew N J Seaman, Brett M Collins   +7 more
doaj   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae

Yeast, Volume 42, Issue 12, Page 283-302, December 2025.
Yeast plasmids expressing human Aβ‐42, α‐syn, htt, and TDP‐43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transport, vacuolar autophagy, and mitochondrial activity. ABSTRACT Here, we review the use of Saccharomyces cerevisiae as a powerful model organism for studying ...
Jose Ribamar Ferreira‐Junior, Vittoria de Lima Camandona, Mario H. Barros   +2 more
wiley   +1 more source

Exosome Tethering Requires Tetherin Homodimerisation

Biology of the Cell, Volume 117, Issue 12, December 2025.
Rather than being released from cells, exosomes can be retained at the plasma membrane via the protein tetherin. Here, we demonstrate that exosome tethering requires the formation of tetherin homodimers, and that mutations in tetherin that impair homodimer formation impair exosome tethering.
Yağmur Yıldızhan, Adam M. Bourke, Hannah K. Jackson, Paul T. Manna, Roberta Palmulli, James R. Edgar   +5 more
wiley   +1 more source

Retromer‐mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21

bioRxiv
Endosomal trafficking ensures the proper distribution of lipids and proteins to various cellular compartments, facilitating intracellular communication, nutrient transport, waste disposal, and the maintenance of cell structure.
M. Romano-Moreno, Elsa N Astorga-Simón, Adriana L Rojas, A. Hierro   +3 more
semanticscholar   +1 more source

Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

Molecular Neurodegeneration, 2010
Background Retrograde transport of several transmembrane proteins from endosomes to the trans-Golgi network (TGN) occurs via Rab 5-containing endosomes, mediated by clathrin and the recently characterized retromer complex.
Gandy Sam, Small Scott A, Lane Rachel, Lah James, Wiltfang Jens, Esselmann Hermann, Rebelo Sandra, Vieira Sandra I, da Cruz e Silva Edgar F, da Cruz e Silva Odete AB   +9 more
doaj   +1 more source