Results 131 to 140 of about 7,439,285 (173)

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through autoinhibition. [PDF]

Proc Natl Acad Sci U S A
Daly JL, Chen KE, Butkovič R, Guo Q, Healy MD, Pennink E, Gamble-Strutt G, Higham Z, Moody ERR, Lewis PA, Heesom KJ, Williams TA, McMillan KJ, Collins BM, Cullen PJ.   +14 more
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Hybrid endosomal coats containing different classes of sorting nexins

Gopaldass N, Chowdhury SR, Alves AC, Mayer LM, Comte-Miserez V, Mayerv A.   +5 more
europepmc   +1 more source

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The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

Journal of Neuroscience Research, 2023
Membrane trafficking is a physiological process encompassing different pathways involved in transporting cellular products across cell membranes to specific cell locations via encapsulated vesicles.
T. Abdul-Rahman, Shankha Ghosh, Jacob Kalmanovich, Andrews Awuah, Marija Zivcevska, Samar Khalifa, Esther Edet Bassey, Namarig Alnil Ali, Matheus S. Ferreira, Tungki Pratama Umar, Neil Garg, V. Nweze, Venkata Sai Sulekhya Inturu, M. Abdelwahab, Sneha Kurian, Athanasios Alexiou, M. Alfaleh, T. Alqurashi, G. Ashraf   +18 more
semanticscholar   +1 more source

Autophagy captures the retromer-TBC1D5 complex to inhibit receptor recycling

Autophagy, 2023
Retromer prevents the destruction of numerous receptors by recycling them from endosomes to the trans-Golgi network or plasma membrane. This enables retromer to fine-tune the activity of many signaling pathways in parallel. However, the mechanism(s) by which retromer function adapts to environmental fluctuations such as nutrient withdrawal and how this
Julian M. Carosi, Leanne K. Hein, Jarrod J. Sandow, Linh V. P. Dang, Kathryn Hattersley, Donna Denton, Sharad Kumar, Timothy J. Sargeant   +7 more
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Identification of novel retromer complexes in the mouse testis

Biochemical and Biophysical Research Communications, 2008
A family of vacuolar protein sorting (Vps) proteins, which are components of mammalian retromer complex, has been studied in the mouse. Vps26a is known as a retromer component that plays an important role in embryonic development: however, its cell-type expression and precise role remain to be elucidated.
Ekyune, Kim, Jae-Woong, Lee, Dong-Chul, Baek, Sang-Rae, Lee, Myeong-Su, Kim, Sang-Hyun, Kim, Kazuhiko, Imakawa, Kyu-Tae, Chang   +7 more
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Scorpion venom heat‐resistant synthetic peptide improves cognitive dysfunction of APP/PS1 mice through microglial retromer complex

British Journal of Pharmacology
The abnormal accumulation of amyloid‐β (Aβ) in the brain is a characteristic pathological change observed in patients with Alzheimer's disease (AD). Microglial phagocytosis, dependent on recycling through the retromer complex and cell membrane‐bound ...
Yue Zhang, Yu-Xia Wu, Xiaogang Zhang, Song-Yu Guo, Jia-Peng He, Na-Na Hu, Yue-Lin Huang, Yue Kong, Qi-Fa Li, Aoran Sui, Bao-Hang Zhu, Hua Piao, Jie Zhao, Shao Li   +13 more
semanticscholar   +1 more source

Functional Architecture of the Retromer Cargo-recognition Complex

Microscopy and Microanalysis, 2008
Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7 ...
G Effantin, A Hierro, AL Rojas, R Rojas, N Murthy, AV Kajava, JS Bonifacino, JH Hurley, AC Steven   +8 more
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Genetic variability of the retromer cargo recognition complex in parkinsonism

Movement Disorders, 2014
AbstractBackgroundA pathogenic mutation (VPS35 p.D620N) within the retromer complex has been shown to segregate with late‐onset Parkinson's disease (PD). Several studies have subsequently detected the mutation in patients with PD and not in controls.MethodsMutation screening of the coding regions of the retromer cargo recognition complex genes (VPS26A ...
Emil K, Gustavsson, Ilaria, Guella, Joanne, Trinh, Chelsea, Szu-Tu, Alex, Rajput, Ali H, Rajput, John C, Steele, Martin, McKeown, Beom S, Jeon, Jan O, Aasly, Matthew J, Farrer   +10 more
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Golgi-associated retrograde protein (GARP) complex recruits retromer to trans-Golgi network for FgKex2 and FgSnc1 recycling, necessary for the development and pathogenicity of Fusarium graminearum.

New Phytologist
In eukaryotes, the retromer complex plays a crucial role in the sorting and retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN).
Yunfei Long, Xin Chen, Jia Chen, Haoran Zhang, Ying Lin, Shuyuan Cheng, Neng Pu, Xuandong Zhou, Renzhi Sheng, Y. S. Abubakar, Huawei Zheng, Yingzi Yun, G. Lu, Zonghua Wang, Wenhui Zheng   +14 more
semanticscholar   +1 more source