Vacuole fragmentation depends on a novel Atg18-containing retromer-complex. [PDF]
Autophagy, 2023 The yeast PROPPIN Atg18 folds as a β-propeller with two binding sites for phosphatidylinositol-3-phosphate (PtdIns3P) and PtdIns(3,5)P2 at its circumference.
Marquardt L +6 more
europepmc +5 more sources
The understudied links of the retromer complex to age-related pathways. [PDF]
Geroscience, 2022 Neuronal aging is associated with numerous diseases resulting in memory impairment and functional decline. A common hallmark of these disorders is the accumulation of intracellular and extracellular protein aggregates.
Wilson KA.
europepmc +6 more sources
Role of Retromer Complex in Neurodegenerative Diseases [PDF]
Frontiers in Aging Neuroscience, 2016 Retromer is a protein complex that plays a central role in endosomal trafficking, and retromer dysfunction has been linked to a growing number of neurological disorders.
Li eChaosi +3 more
doaj +5 more sources
VPS35, the core component of the retromer complex, and Parkinson's disease. [PDF]
Ibrain, 2021 Parkinson's disease (PD) is a neurodegenerative disease that is common in middle‐aged and elderly people, and its onset is related to multiple factors, such as heredity, environment, and age.
Luo AD, Xu ZC, Liao SS.
europepmc +6 more sources
Dysregulation of the Retromer Complex System in Down Syndrome. [PDF]
Ann Neurol, 2020 Most of the patients with Down syndrome (DS) develop Alzheimer's disease (AD) neuropathology by age 40. Although this increased susceptibility to AD in DS is thought to be primarily due to triplication of the amyloid precursor protein located on ...
Curtis ME, Yu D, Praticò D.
europepmc +5 more sources
Endosomal sorting and trafficking, the retromer complex and neurodegeneration. [PDF]
Mol Psychiatry, 2019 The retromer is a highly conserved multimeric protein complex present in all eukaryotic cells whose activity is essential for regulating the recycling and retrieval of numerous protein cargos from the endosome to trans-Golgi network or the cell surface ...
Vagnozzi AN, Praticò D.
europepmc +5 more sources
VPS29C: Adding complexity to the Retromer complex. [PDF]
Proc Natl Acad Sci U S AChen B, Burstein E, Billadeau DD.
europepmc +4 more sources
Retromer Regulates Macro‐ and Micro‐Autophagy via Distinct Vacuolar Proteases in the Rice Blast Fungus [PDF]
Advanced ScienceThe vacuole degrades and recycles endocytic and autophagic cargos, while the retromer complex sorts cargos from the endosomes to the trans‐Golgi network or the plasma membrane, thus preventing unnecessary vacuolar degradation.
Dingyang Zhang +13 more
doaj +3 more sources
Oxidation of retromer complex controls mitochondrial translation. [PDF]
NatureReactive oxygen species (ROS) underlie human pathologies including cancer and neurodegeneration1,2. However, the proteins that sense ROS levels and regulate their production through their cysteine residues remain ill defined. Here, using systematic base-editing and computational screens, we identify cysteines in VPS35, a member of the retromer ...
Zhang J +34 more
europepmc +4 more sources
Updated Insight into the Physiological and Pathological Roles of the Retromer Complex. [PDF]
Int J Mol Sci, 2017 Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 ...
Abubakar YS, Zheng W, Olsson S, Zhou J.
europepmc +5 more sources