Results 21 to 30 of about 7,439,285 (173)

The regulatory role of the Aspergillus flavus core retromer complex in aflatoxin metabolism. [PDF]

J Biol Chem, 2022
Aflatoxins are a series of highly toxic and carcinogenic secondary metabolites that are synthesized by Aspergillus species. The degradation of aflatoxin enzymes is an important regulatory mechanism which modulates mycotoxin producing.
Wang S, Wang Y, Liu Y, Liu L, Li J, Yang K, Liu M, Zeng W, Qin L, Lin R, Nie X, Jiang L, Wang S.   +12 more
europepmc   +2 more sources

Plant ESCRT protein ALIX coordinates with retromer complex in regulating receptor-mediated sorting of soluble vacuolar proteins. [PDF]

Proc Natl Acad Sci U S A, 2022
Significance The endosomal sorting complex required for transport (ESCRT) machinery in multicellular organisms plays canonical functions in multivesicular body (MVB) biogenesis and membrane protein sorting.
Hu S, Li B, Wu F, Zhu D, Zouhar J, Gao C, Shimada T, Rojo E, Hara-Nishimura I, Jiang L, Shen J.   +10 more
europepmc   +2 more sources

FgRab5 and FgRab7 are essential for endosomes biogenesis and non-redundantly recruit the retromer complex to the endosomes in Fusarium graminearum. [PDF]

Stress Biol, 2021
The retromer complex, composed of the cargo-selective complex (CSC) Vps35-Vps29-Vps26 in complex with the sorting nexin dimer Vps5-Vps17, mediates the sorting and retrograde transport of cargo proteins from the endosomes to the trans-Golgi network in ...
Abubakar YS, Qiu H, Fang W, Zheng H, Lu G, Zhou J, Wang Z, Zheng W.   +7 more
europepmc   +2 more sources

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex. [PDF]

Proc Natl Acad Sci U S A
Endosomal membrane trafficking is mediated by specific protein coats and formation of actin-rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27–Retromer assembly interacts with ...
Guo Q, Chen KE, Gimenez-Andres M, Jellett AP, Gao Y, Simonetti B, Liu M, Danson CM, Heesom KJ, Cullen PJ, Collins BM.   +10 more
europepmc   +2 more sources

The Retromer Complex: From Genesis to Revelations.

Trends in Biochemical Sciences, 2021
The retromer complex has a well-established role in endosomal protein sorting, being necessary for maintaining the dynamic localisation of hundreds of membrane proteins that traverse the endocytic system.
M. Seaman
semanticscholar   +4 more sources

The Parkinson Disease-Associated Mutant DNAJC13(N855S) Leads to Its Accelerated Degradation and Negatively Affects Macroautophagy and Retromer Complex-Mediated Dynamics. [PDF]

J Cell Physiol
While Parkinson′s disease has a multifactorial etiology, 5%–10% of cases present with identifiable disease‐causing gene mutations. Further investigation into these mutations is a way to identify underlying pathologic mechanism.
Stein A, Vo S, Freese C, Kluge J, Maus J, Koziollek-Drechsler I, Silva B, Behl C, Clement AM.   +8 more
europepmc   +2 more sources

Validation of a binding site on the SORLA‐retromer complex that augments endosomal recycling: Implications for a novel class of AD drugs [PDF]

Alzheimers Dement
Genetic studies have established that loss of function SORL1 gene variants are associated with Alzheimer’s disease (AD). SORL1 encodes an endosomal trafficking receptor, SORLA, which regulates endosomal protein recycling through its interaction with the ...
Merchant K, Andersen O, Lefker B, Withka J, Small S, Petsko G, Klein J, Armstrong R.   +7 more
europepmc   +2 more sources

Lysosomal down-regulation of the mu opioid receptor is opposed by the Retromer complex. [PDF]

Sci Adv
A critical homeostatic mechanism for regulating G protein–coupled receptor (GPCR) activity is agonist-induced GPCR endocytosis and trafficking to the lysosome for proteolytic down-regulation. The mu opioid receptor (MOR) is a notable example of this type
Dagunts A, Adoff H, Novy B, Ameur LB, De Maria M, Saunders A, Lobingier BT.   +6 more
europepmc   +2 more sources

Honokiol enhances the sensitivity of cetuximab in KRAS^G13D mutant colorectal cancer through destroying SNX3-retromer complex. [PDF]

Theranostics
Rationale: the proto-oncogene KRAS is frequently mutated in colorectal cancer (CRC), leading to inherent resistance against monoclonal antibodies targeting the epidermal growth factor receptor (EGFR), such as cetuximab.
Zhu Q, Zhang R, Gu X, Zhao Z, Gao Q, Chen M, Wu Q, Xie T, Sui X.   +8 more
europepmc   +2 more sources

A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling. [PDF]

J Cell Biol, 2019
Retromer sorts diverse membrane proteins into recycling tubules/vesicles from the endosome. How it precisely selects its cargos is not well described. Suzuki et al. reveal that retromer interacts with a bipartite sorting signal, which facilitates precise
Suzuki SW, Chuang YS, Li M, Seaman MNJ, Emr SD.   +4 more
europepmc   +2 more sources