Gibberellin DELLA signaling targets the retromer complex to redirect protein trafficking to the plasma membrane. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance This study identifies and outlines a nontranscriptional branch of the canonical GA signaling pathway that redirects protein traffic from the vacuolar degradation route to the plasma membrane.
Salanenka Y +6 more
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Unconventional endosome-like compartment and retromer complex in Toxoplasma gondii govern parasite integrity and host infection [PDF]
Nature Communications, 2016 The retromer complex is a multi-protein component of the endosomal protein sorting machinery. Here, Sangaré et al. identify unique features in the retromer complex of the parasite Toxoplasma gondii, and show that it is crucial for the biogenesis of ...
Lamba Omar Sangaré +12 more
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Proteomic Identification of Cytokeratin 19 Association with Retromer Reveals a Connection with Cellular Dynamics [PDF]
CellsRetromer is an evolutionarily conserved protein complex first identified in budding yeast. It was originally described for its essential role in endosome-to-Golgi retrieval of lysosomal hydrolase receptors. Retromer is now known to mediate trafficking of
Marcel Verges
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Retro Is Cool: Structure of the Versatile Retromer Complex. [PDF]
Structure, 2020 In this issue of Structure, Kendall et al. (2020) reveal the cryo-EM structure of the mammalian retromer complex, which is essential in sorting membrane proteins in endosomes.
Leonora Martínez-Núñez, M. Munson
semanticscholar +3 more sources
Hybrid endosomal coats contain different classes of sorting nexins [PDF]
The EMBO JournalEndosomes are protein sorting stations, where multiple membrane coats form tubulovesicular carriers exporting proteins to the Golgi, the plasma membrane, or endo-lysosomal compartments.
Navin Gopaldass +5 more
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A therapeutic roadmap to restore the SORL1‐retromer recycling complex
Alzheimer's & DementiaGenetic, cell biology and autopsied brain tissue studies indicate that deficits in the SORL1‐retromer complex play a critical role in the pathogenesis of Alzheimer’s disease (AD).
Kalpana M. Merchant
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Structural Mechanism for Cargo Recognition by the Retromer Complex. [PDF]
Cell, 2016 Retromer is a multi-protein complex that recycles transmembrane cargo from endosomes to the trans-Golgi network and the plasma membrane. Defects in retromer impair various cellular processes and underlie some forms of Alzheimer's disease and Parkinson's disease.
Lucas M +5 more
europepmc +5 more sources
Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2022 Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby ...
Shun Yoshida +2 more
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Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer's disease neurons. [PDF]
Hum Mol Genet, 2017 Tammineni P +4 more
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The retromer complex in development and disease. [PDF]
Development, 2015 The retromer complex is a multimeric protein complex involved in recycling proteins from endosomes to the trans-Golgi network or plasma membrane. It thus regulates the abundance and subcellular distribution of its cargo within cells. Studies using model organisms show that the retromer complex is involved in specific developmental processes.
Wang S, Bellen HJ.
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