Results 51 to 60 of about 7,439,285 (173)
eLife, 2020 Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult ...
Hui Ye +10 more
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Understanding the contributions of VPS35 and the retromer in neurodegenerative disease
Neurobiology of Disease, 2022 Perturbations of the endolysosomal pathway have been suggested to play an important role in the pathogenesis of several neurodegenerative diseases, including Parkinson's disease (PD) and Alzheimer's disease (AD).
Erin T. Williams +3 more
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Navigating the Controversies of Retromer-Mediated Endosomal Protein Sorting
Frontiers in Cell and Developmental Biology, 2021 The retromer complex was first identified more than 20 years ago through studies conducted in the yeast Saccharomyces cerevisiae. Data obtained using many different model systems have revealed that retromer is a key component of the endosomal protein ...
Yingfeng Tu, Matthew N. J. Seaman
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VPS29–VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process [PDF]
FEBS Letters, 2015 Retromer is a complex of proteins that functions in the endosome‐to‐Golgi retrieval cargo transport pathway. VPS35 works as the central subunit of retromer to recognize the cargos and binds with VPS29 and VPS26 via distinct domains. We show that deficiency of VPS35 or VPS29 accompanies degradation of other subunits, whereas VPS26 deficiency had no ...
Fuse, Atsuhito +7 more
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Retromer in Synaptic Function and Pathology
Frontiers in Synaptic Neuroscience, 2018 The retromer complex mediates export of select transmembrane proteins from endosomes to the trans-Golgi network (TGN) or to the plasma membrane. Dysfunction of retromer has been linked with slowly progressing neurodegenerative disorders, including ...
Lennart Brodin +2 more
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CROP: a retromer‐PROPPIN complex mediating membrane fission in the endo‐lysosomal system [PDF]
The EMBO Journal, 2021 AbstractEndo-lysosomal compartments exchange proteins by fusing, fissioning, and through endosomal transport carriers. Thereby, they sort many plasma membrane receptors and transporters and control cellular signaling and metabolism. How the membrane fission events are catalyzed is poorly understood.
Thibault Courtellemont +3 more
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HPV virions hitchhike a ride on retromer complexes [PDF]
Proceedings of the National Academy of Sciences, 2013 Nonenveloped viruses use cellular pathways to gain access to and traverse the cytoplasm of host cells. Indeed, many of the by now well-established pathways have been initially identified during the study of virus entry. In PNAS, Lipovsky et al.
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Traffic, 2022 Abstract The pentameric WASH complex facilitates endosomal protein sorting by activating Arp2/3, which in turn leads to the formation of F‐actin patches specifically on the endosomal surface. It is generally accepted that WASH complex attaches to the endosomal membrane via the interaction of its subunit FAM21 with
V. Dostál +4 more
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Retromer regulates HIV-1 envelope glycoprotein trafficking and incorporation into virions.
PLoS Pathogens, 2014 The envelope glycoprotein (Env) of the Human Immunodeficiency Virus Type-1 (HIV-1) is a critical determinant of viral infectivity, tropism and is the main target for humoral immunity; however, little is known about the cellular machinery that directs Env
Elisabetta Groppelli +3 more
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The retromer complex - endosomal protein recycling and beyond. [PDF]
J Cell Sci, 2012 The retromer complex is a vital element of the endosomal protein sorting machinery that is conserved across all eukaryotes. Retromer is most closely associated with the endosome-to-Golgi retrieval pathway and is necessary to maintain an active pool of hydrolase receptors in the trans-Golgi network. Recent progress in studies of retromer have identified
Seaman MN.
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