Results 61 to 70 of about 7,439,285 (173)
A mechanism for retromer endosomal coat complex assembly with cargo [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance The endosomal system is a network of organelles that play key roles in nutrient uptake, protein and lipid sorting, and signal transduction. Integral membrane proteins are delivered to endosomes via trafficking from the plasma membrane and the secretory pathway, and many of these proteins are then returned from the endosome for ...
Megan S, Harrison +5 more
openaire +2 more sources
Neurobiology of Disease, 2012 The retromer complex plays an important role in intracellular transport, is highly expressed in the hippocampus, and has been implicated in the trafficking of the amyloid precursor protein (APP).
Akhil Bhalla +5 more
doaj +1 more source
Parkinsonism & Related Disorders, 2021 INTRODUCTION To identify and investigate patients with Parkinson's disease (PD) harboring VPS35 variants in Japan. METHODS Using targeted gene panel screening, we analyzed 393 familial, 294 young-onset, and 52 late-onset sporadic PD patients derived ...
Mayu Ishiguro +9 more
semanticscholar +1 more source
Assembly and Solution Structure of the Core Retromer Protein Complex [PDF]
Traffic, 2010 Retromer is a peripheral membrane protein complex that has pleiotropic roles in endosomal membrane trafficking. The core of retromer possesses three subunits, VPS35, VPS29 and VPS26, that play different roles in binding to cargo, regulatory proteins and complex stabilization.
Norwood, SJ +5 more
openaire +3 more sources
Retromer disruption promotes amyloidogenic APP processing
Neurobiology of Disease, 2011 Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in ...
Christopher P. Sullivan +7 more
doaj +1 more source
Nature Communications, 2023 Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network.
James L. Daly +13 more
doaj +1 more source
The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat
eLife, 2022 Membrane trafficking pathways perform important roles in establishing and maintaining the endosomal network. Retrograde protein sorting from the endosome is promoted by conserved SNX-BAR-containing coat complexes including retromer which enrich cargo at ...
Shawn P Shortill +4 more
doaj +1 more source
The retromer complex regulates C. elegans development and mammalian ciliogenesis
bioRxiv, 2021 The mammalian retromer is comprised of subunits VPS26, VPS29 and VPS35, and a more loosely-associated sorting nexin (SNX) heterodimer. Despite known roles for the retromer in multiple trafficking events in yeast and mammalian cells, its role in ...
Shuwei Xie +8 more
semanticscholar +1 more source
PTEN Regulates Glucose Transporter Recycling by Impairing SNX27 Retromer Assembly
Cell Reports, 2017 Summary: The tumor suppressor PTEN executes cellular functions predominantly through its phosphatase activity. Here we identified a phosphatase-independent role for PTEN during vesicular trafficking of the glucose transporter GLUT1.
Swapnil Rohidas Shinde +1 more
doaj +1 more source
Actin polymerization in the endosomal pathway, but not on the Coxiella-containing vacuole, is essential for pathogen growth. [PDF]
PLoS Pathogens, 2018 Coxiella burnetii is an intracellular bacterium that replicates within an expansive phagolysosome-like vacuole. Fusion between the Coxiella-containing vacuole (CCV) and late endosomes/multivesicular bodies requires Rab7, the HOPS tethering complex, and ...
Heather E Miller +2 more
doaj +1 more source