Results 71 to 80 of about 7,439,285 (173)
Multifaceted Roles of Retromer in EGFR Trafficking and Signaling Activation
Cells, 2022 Mammalian retromer complex contributes to multiple early endosome-associated trafficking pathways whose origins are dependent on which sorting nexin (SNX) they are complexed with.
Zhe Yang +3 more
doaj +1 more source
Intercompartmental communication in senescence
FEBS Open Bio, EarlyView.Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz +3 more
wiley +1 more source
Nature Communications, 2018 Sustained Wnt secretion requires the endosomal SNX3-retromer complex for endosome-to-trans-Golgi network transport of the internalised Wnt chaperone Wntless. Here the authors show that in both C.
Ian J. McGough +8 more
doaj +1 more source
Hyperleucinemia causes hippocampal retromer deficiency linking diabetes to Alzheimer's disease
Neurobiology of Disease, 2014 Type 2 diabetes (T2D) is a major risk factor for late-onset Alzheimer's disease (AD). A variety of metabolic changes related to T2D (e.g. hyperinsulinemia, hyperglycemia, and elevated branched-chain amino acids) have been proposed as mechanistic links ...
Michael V. Morabito +5 more
doaj +1 more source
Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease
Frontiers in Cell and Developmental Biology, 2021 Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of cellular sorting processes and can drive severe physiological outcomes.
Mintu Chandra +6 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies vacuole membrane protein 1 (VMP1) as a critical regulator of intestinal epithelial barrier homeostasis. VMP1 facilitates the recruitment of CORO1C to late endosomes, supporting Retromer‐mediated recycling of the tight junction protein Occludin.
Jiawei Zhao +12 more
wiley +1 more source
The Structure and Function of the Retromer Protein Complex [PDF]
Traffic, 2008 The transport of transmembrane proteins and associated ligands through the endosomal system is governed by a number of different protein assemblies. One such assembly is retromer, a peripheral membrane protein complex that has important roles in endosomal sorting of a variety of cargo molecules.
openaire +3 more sources
Diversity of retromer-mediated vesicular trafficking pathways in plants
Frontiers in Plant Science, 2023 The plant endomembrane system is organized and regulated by large gene families that encode proteins responsible for the spatiotemporal delivery and retrieval of cargo throughout the cell and to and from the plasma membrane.
Suryatapa Ghosh Jha, Emily R. Larson
doaj +1 more source
Interdisciplinary Medicine, EarlyView.Discovery and validation of a urinary extracellular vesicle protein signature for the diagnosis of renal allograft fibrosis. Abstract Interstitial fibrosis is the best indicator of irreversible or ongoing renal injury after kidney transplantation and faces considerable diagnostic challenges.
Wenxuan Zhao +12 more
wiley +1 more source
Regulation of the endosomal SNX27-retromer by OTULIN
Nature Communications, 2019 OTULIN is a linear ubiquitin hydrolase that regulates ubiquitin homeostasis. Here the authors identify the adaptor of the endosomal retromer complex sorting nexin 27 (SNX27) as a binding partner of OTULIN and determine the structure of the OTULIN-SNX27 ...
Aurelia Stangl +12 more
doaj +1 more source