Results 51 to 60 of about 56,147 (242)
Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses
Advanced Science, EarlyView.ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti +13 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2023 Cells of the developing human brain are affected by the progressive acquisition of genetic and epigenetic alterations that have been reported to contribute to somatic mosaicism in the adult brain and are increasingly considered a possible cause of ...
Jonas Möhner +4 more
doaj +1 more source
The nitrate transporter family protein LjNPF8.6 controls the N-fixing nodule activity [PDF]
, 2017 N-fixing nodules are new organs formed on legume roots as a result of the beneficial interaction with soil bacteria, rhizobia. The nodule functioning is still a poorly characterized step of the symbiotic interaction, as only a few of the genes induced in
Chiurazzi, Maurizio +7 more
core +3 more sources
Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions
Advanced Science, EarlyView.This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang +4 more
wiley +1 more source
Molecular Oncology, 2018 Long interspersed nuclear element‐1 (LINE‐1 or L1) reactivation is linked to poor prognosis in non‐small‐cell lung carcinoma (NSCLC), but the molecular bases of this response remain largely unknown.
Pasano Bojang Jr., Kenneth S. Ramos
doaj +1 more source
eLife, 2018 The mechanisms by which a retrotransposon called LINE-1 duplicates itself and spreads through the human genome are becoming clearer.
Sandra L Martin
doaj +1 more source
Intragenic L1 Insertion: One Possibility of Brain Disorder
Life, 2022 Long interspersed nuclear element 1 (LINE1, L1) is a retrotransposon comprising ~17% of the human genome. A subset of L1s maintains the potential to mobilize and alter the genomic landscape, consequently contributing to the change in genome integrity and
Ji-Hoon Son, Hyunsu Do, Jinju Han
doaj +1 more source
A chromosome-scale genome assembly of Hordeum erectifolium: genomic, transcriptomic and anatomical adaptations to drought in a wild barley relative. [PDF]
New PhytolSummary Wild crop relatives are valuable genetic resources for improving stress adaptation in cultivated species, but their effective use depends on high‐quality reference genomes integrated with phenotypic and molecular datasets. Hordeum erectifolium, a wild relative of barley (H.
Haraldsson EB +8 more
europepmc +2 more sources
Nucleosomes affect local transformation efficiency [PDF]
, 2012 Genetic transformation is a natural process during which foreign DNA enters a cell and integrates into the genome. Apart from its relevance for horizontal gene transfer in nature, transformation is also the cornerstone of today's recombinant gene ...
Aslankoohi, Elham +6 more
core +2 more sources
Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng +18 more
wiley +1 more source