Results 211 to 220 of about 117,013 (259)
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Oligomerization of Retrovirus Integrases
2018Integration of the reverse-transcribed viral cDNA into the host's genome is a critical step in the lifecycle of all retroviruses. Retrovirus integration is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric 'intasome' complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of ...
Duane P, Grandgenett, Hideki, Aihara
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Retrovirus in multiple sclerosis
Acta Neurologica Scandinavica, 1989Presence of cytopathic effect and enzyme reverse transcriptase in cultures of peripheral blood mononuclear cells is described in 2 of 15 patients with multiple sclerosis and none of healthy controls. These findings might indicate: the presence of a new human retrovirus in these individuals, despite the low detection rate, and the shortcomings inherent ...
S, Kam-Hansen +3 more
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Retrovirus insertion into herpesviruses
Trends in Microbiology, 1994Recent studies have indicated that retroviruses can integrate into and mutate the genomes of herpesviruses during co-infection. This interaction has the potential to change the host range and pathogenicity of both viruses and result in novel infectious agents and diseases.
R J, Isfort, R, Witter, H J, Kung
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Retrovirus variation and evolution
Genome, 1989Sixty-seven years ago in Toronto at the 39th Annual Meeting of the American Society of Naturalists, H. J. Muller (1922) in a theoretical talk entitled "Variation due to Change in the Individual Gene" discussed the newly described d'HCrelle bodies, which he stated "fulfills our definition of a gene", and Gratia's finding that these bodies could change ...
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2018
The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration.
Wei, Zhang +2 more
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The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration.
Wei, Zhang +2 more
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Retrovirus Phylogeny and Evolution
1990The elucidation of complete genomic sequences from a wide variety of retroviruses and retrotransposons has allowed the construction of sequence-based phylogenies that reveal their evolutionary history. True retroviruses, whether exogenous or endogenous, tend to cluster into four major groups.
R F, Doolittle +3 more
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Retrovirus-Associated Myelopathies
Archives of Neurology, 1987Human T-lymphotropic virus type I (HTLV-I), the causative agent of adult T-cell leukemia and non-Hodgkin's lymphoma (ATLL)--or a cross-reacting retrovirus--has been associated with tropical spastic paraparesis in Martinique, Jamaica, Colombia, Trinidad and Tobago, the Seychelles, and probably also in Zaire.
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Retrovirus Envelope Glycoproteins
1990The envelope glycoprotein complex of replication competent retroviruses is comprised of two polypeptides, an external, glycosylated, hydrophilic polypeptide (SU) and a membrane-spanning protein (TM), that form a knob or knobbed spike on the surface of the virion.
E, Hunter, R, Swanstrom
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Human Gene Therapy, 1990
Retroviral vectors promote the efficient transfer of genes into a variety of cell types from many animal species. An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retroviral vectors in the absence of replication-competent virus.
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Retroviral vectors promote the efficient transfer of genes into a variety of cell types from many animal species. An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retroviral vectors in the absence of replication-competent virus.
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