Results 91 to 100 of about 124,737 (275)
Force for ancient and recent life: viral and stem-loop RNA consortia promote life. [PDF]
, 2014 Lytic viruses were thought to kill the most numerous host (i.e., kill the winner). But persisting viruses/defectives can also protect against viruses, especially in a ubiquitous virosphere. In 1991, Yarmolinsky et al.
Villarreal, Luis P
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Biotechnology Progress, EarlyView.Integrating non‐chromatographic operations, such as low pH viral inactivation and a depth filtration mimic, into an automated micro‐scale platform enhances productivity while reducing resource and time requirements. By facilitating rapid, data‐rich experimentation, the platform offers a powerful and efficient tool for assessing and optimizing ...
Paras Sharma +4 more
wiley +1 more source
Evolution of Foamy Viruses: The Most Ancient of All Retroviruses
Viruses, 2013 Recent evidence indicates that foamy viruses (FVs) are the oldest retroviruses (RVs) that we know and coevolved with their hosts for several hundred million years. This coevolution may have contributed to the non-pathogenicity of FVs, an important factor
Jochen Bodem, Axel Rethwilm
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Biotechnology Progress, EarlyView.Abstract As adeno‐associated viral vectors (AAV) continue to advance through the clinical pipeline, effective downstream purification strategies must be developed to ensure bulk drug purity and safety. AAV are produced within mammalian cells, bringing forth risks associated with viral contamination.
Akshay S. Chaubal +5 more
wiley +1 more source
Viruses, 2016 Interaction of viral envelope proteins with host cell membranes has been extensively investigated in a number of systems. However, the biological relevance of these interactions in vivo has been hampered by the absence of adequate animal models.
Alix de Brogniez, Jan Mast, Luc Willems
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Transposable Elements, Inflammation, and Neurological Disease. [PDF]
, 2019 Transposable Elements (TE) are mobile DNA elements that can replicate and insert themselves into different locations within the host genome. Their propensity to self-propagate has a myriad of consequences and yet their biological significance is not well-
Macia, Angela +2 more
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Epilepsia Open, EarlyView.Abstract Objective This study aims to investigate the causal relationship between cathepsins and epilepsy, using Mendelian randomization (MR) and mediation analysis. Methods Publicly accessible summary statistics on epilepsy were obtained from FinnGen and the International League Against Epilepsy Consortium.
Huaiyu Sun +7 more
wiley +1 more source
The Diverse Roles of microRNAs at the Host–Virus Interface
Viruses, 2018 MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date.
Annie Bernier, Selena M. Sagan
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Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles [PDF]
, 1996 Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of
Aster, Jon C. +6 more
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Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials. [PDF]
, 2009 BACKGROUND: Directly observed therapy has been recommended to improve adherence for patients with HIV infection who are on highly active antiretroviral therapy, but the benefit and cost-effectiveness of this approach has not been established conclusively.
Altice +41 more
core +3 more sources