Results 91 to 100 of about 84,233 (235)

The Diverse Roles of microRNAs at the Host–Virus Interface

Viruses, 2018
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date.
Annie Bernier, Selena M. Sagan
doaj   +1 more source

Tumor‐Intrinsic Forkhead Box A2 Regulates the Lymph Node Metastasis of Papillary Thyroid Carcinoma by Regulating T‐Cell Apoptosis

iLABMED, EarlyView.
We identified FOXA2 as a key regulator of lymph node metastasis in thyroid cancer, which controls cancer cell aggressiveness. FOXA2 knockdown promotes metastasis by enhancing tumor cell migration and, importantly, by inducing T‐cell apoptosis through a CCL2/LCN2‐mediated pathway. Created with BioGDP.com.
Ping Yang, Xueying Zhang, Wen Deng, Fangning Gao, Shujia Peng, Guoqiang Bao, Lijuan Yuan   +6 more
wiley   +1 more source

Anti-viral activity of red microalgal polysaccharides against retroviruses

Cancer Cell International, 2002
Red microalgal polysaccharides significantly inhibited the production of retroviruses (murine leukemia virus- MuLV) and cell transformation by murine sarcoma virus(MuSV-124) in cell culture.
Huleihel Mahmoud M, Souprun Yelena Y, Talyshinsky Marina M   +2 more
doaj   +1 more source

Viroids-First—A Model for Life on Earth, Mars and Exoplanets

Geosciences, 2019
The search for extraterrestrial life, recently fueled by the discovery of exoplanets, requires defined biosignatures. Current biomarkers include those of extremophilic organisms, typically archaea.
Karin Moelling, Felix Broecker
doaj   +1 more source

Origin of the retroviruses: when, where, and how?

Current Opinion in Virology, 2017
Highlights • Retroviruses are a virus family of considerable medical and veterinary importance.• Until recently, very little was known about deep retroviral origins.• New research supports a marine origin of retroviruses, ∼460–550 million years ago.• The
Alexander Hayward
semanticscholar   +1 more source

Upregulation of sphingomyelin and ABCA8 in response to TDP‐43 pathology in amyotrophic lateral sclerosis brain

Brain Pathology, EarlyView.
Increases in sphingomyelin in response to TDP‐43 pathology in the disease‐affected motor cortex of amyotrophic lateral sclerosis (ALS) brain. Abstract Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease characterized by the degeneration of motor neurons and the presence of TAR DNA‐binding protein 43 (TDP‐43 ...
Finula I. Isik, Russell Pickford, Nicolas Dzamko, Kerry‐Anne Rye, Woojin Scott Kim   +4 more
wiley   +1 more source

Revisiting Plus-Strand DNA Synthesis in Retroviruses and Long Terminal Repeat Retrotransposons: Dynamics of Enzyme: Substrate Interactions

Viruses, 2009
Although polypurine tract (PPT)-primed initiation of plus-strand DNA synthesis in retroviruses and LTR-containing retrotransposons can be accurately duplicated, the molecular details underlying this concerted series of events remain largely unknown ...
Stuart F. J. Le Grice, John P. Marino, Daniele Fabris   +2 more
doaj   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

On the Selective Packaging of Genomic RNA by HIV-1

Viruses, 2016
Like other retroviruses, human immunodeficiency virus type 1 (HIV-1) selectively packages genomic RNA (gRNA) during virus assembly. However, in the absence of the gRNA, cellular messenger RNAs (mRNAs) are packaged.
Mauricio Comas-Garcia, Sean R. Davis, Alan Rein   +2 more
doaj   +1 more source

Degradation and remobilization of endogenous retroviruses by recombination during the earliest stages of a germ-line invasion

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Endogenous retroviruses (ERVs) are proviral sequences that result from host germ-line invasion by exogenous retroviruses. The majority of ERVs are degraded.
Ulrike Löber, M. Hobbs, A. Dayaram, K. Tsangaras, Kiersten Jones, D. E. Alquezar‐Planas, Y. Ishida, J. Meers, J. Mayer, C. Quedenau, Wei Chen, Rebecca N. Johnson, P. Timms, P. Young, A. Roca, A. Greenwood   +15 more
semanticscholar   +1 more source