Results 81 to 90 of about 68,205 (163)

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Letermovir in Refractory and Resistant CMV After Lung Transplantation: Therapeutic Potential and Emergence of Resistance

Transplant Infectious Disease, EarlyView.
Letermovir use for active R/R CMV infection was associated with treatment‐emergent resistance in approximately one‐third of patients, particularly in those with high baseline viral loads and delayed virological response. These findings support careful patient selection, close virological monitoring, and early resistance testing.
Tobias Veit, Stefan Trost, Teresa Kauke, Nina Engels, Gabriela Leuschner, Michael Gerckens, Carlo Mümmler, Sebastian Michel, Michael Zoller, Valeria Hackemann, Jürgen Behr, Nikolaus Kneidinger   +11 more
wiley   +1 more source

HTLV screening and confirmatory testing among blood donors in São Paulo: A cross‐sectional study

Transfusion Medicine, EarlyView.
Abstract Introduction Human T‐cell lymphotropic virus types 1 and 2 (HTLV‐1/2) are transfusion‐transmissible retroviruses associated with severe diseases, and blood donor screening is mandatory in Brazil. Increasing HTLV‐related discard rates at our institution prompted this study to determine the prevalence and incidence of HTLV‐1/2 and to investigate
Suzete C. Ferreira, Anna S. Nishyia, Jerenice E. Ferreira, Claudia Di Lorenzo Oliveira, Cesar de Almeida‐Neto, Tila Fanciani, Katia C. Dantas, Juliana Derriga, Silvia Petrossi Gallo Polato, Nanci Salles, Vanderson Rocha, Alfredo Mendrone‐Junior   +11 more
wiley   +1 more source

dNTP depletion and beyond: the multifaceted nature of SAMHD1-mediated viral restriction

Journal of Virology
SAMHD1 is a dNTPase of mammalian cells. In 2011, SAMHD1 was found to be a host restriction factor against retroviruses through dNTP reduction. Recent research provides evidence that the antiviral mechanisms of SAMHD1 cannot be explained solely by its ...
Pak-Hin Hinson Cheung, Hua Yang, Li Wu
doaj   +1 more source

Ascending infection of Gardnerella spp. and compartmentalized inflammatory response in fetal–maternal interface organ‐on‐chip model

The Journal of Physiology, EarlyView.
Abstract figure legend The fetal–maternal interface organ‐on‐chip was used to investigate the ascending infection of Gardnerella spp. across the decidua (DEC), chorion trophoblast (CTC), amnion mesenchymal (AMC) and amnion epithelial (AEC) compartments over 48 h.
Mariana de Castro Silva, Jeniffer Sena Baptista Ferreira, Rafael Gomes Barnabé, Maria Eduarda Tesini Rocha, Laura Emi Yonezawa de Souza, Bruna Ribeiro de Andrade Ramos, Ramkumar Menon, Márcia Guimarães da Silva   +7 more
wiley   +1 more source

Neuronal Overexpression of Glycogen Synthase Kinase‐3β Accelerates Age‐Related Glial, Vascular, and Inflammatory Remodeling of the Murine Dentate Gyrus

Glia, Volume 74, Issue 12, December 2026.
Aging induces layer‐specific changes in glial populations and vascular organization across the dentate gyrus. Neuronal GSK‐3β overexpression accelerates age‐related remodeling of the dentate gyrus neurogenic niche. GSK‐3β‐overexpressing mice show premature subgranular zone (SGZ) astrocyte loss, altered microglia and oligodendroglia, and vascular ...
Ana V. Prádanos‐Senén, Carla B. Rodríguez‐Moreno, María Llorens‐Martín   +2 more
wiley   +1 more source

Distinct Epigenetic Responses to Aging and Short‐Term High‐Fat Diet in Hepatic Lipid Metabolism Genes in Male and Female Mice

Liver International Communications, Volume 7, Issue 4, December 2026.
ABSTRACT Background and Aims Aging is associated with widespread epigenetic remodelling that contributes to metabolic alterations in the liver. High‐fat diet (HFD) represents a major environmental perturbation affecting hepatic metabolism, yet its specific impact on age‐associated epigenetic changes remains unclear.
Annalena Frank, Sascha Tierling, Beate Czepukojc, Sonja M. Kessler, Thomas Hentrich, Michael Kohlstedt, Johannes Haybaeck, Christoph Wittmann, Jessica Hoppstädter, Julia Schulze‐Hentrich, Alexandra K. Kiemer   +10 more
wiley   +1 more source

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER–Lysosome Calcium Signaling

Traffic, Volume 27, Issue 4, December 2026.
Hypothetical model: The lysosomal protein TMEM55B interacts with an ER protein complex containing Protrudin and PDZD8 at ER–lysosome membrane contact sites, and also acts to stabilize v‐ATPase in lysosomes. Through these interactions, TMEM55B contributes to the maintenance of luminal homeostasis, including lysosomal acidification and regulates ER ...
Nagi Mukae, Honoka Maki, Michiko Shirane
wiley   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

Nano Borophene as a Programmable 2D Scaffold for Organized DNA Assembly and Long‐Range Energy Transfer

Advanced Functional Materials, Volume 36, Issue 88, 2 November 2026.
Borophene is introduced as a programmable 2D bio‐interface that organizes DNA through dual boron–sulfur and nucleobase interactions. This molecular architecture enables efficient long‐range nanosurface energy transfer, establishing new design principles for functional nano–bio interfaces and amplification‐free optical biosensing.
Teresa Aditya, Pranay Saha, John M. Sansalone, Shraddha Krishnakumar, Matthew Molinaro, André J. van der Vlies, Nada Maher, Adrienne Griffiths, Zakhro Zakirova, Ketan Dighe, Narayana R. Aluru, Dipanjan Pan   +11 more
wiley   +1 more source