Results 61 to 70 of about 68,205 (163)

Determinants of the Bovine Leukemia Virus Envelope Glycoproteins Involved in Infectivity, Replication and Pathogenesis

open access: yesViruses, 2016
Interaction of viral envelope proteins with host cell membranes has been extensively investigated in a number of systems. However, the biological relevance of these interactions in vivo has been hampered by the absence of adequate animal models.
Alix de Brogniez, Jan Mast, Luc Willems
doaj   +1 more source

Haematology and biochemistry parameters for koalas (Phascolarctos cinereus) on Raymond Island, Victoria: use of point‐of‐care analysers

open access: yesAustralian Veterinary Journal, EarlyView.
Biochemistry and haematology analytes can provide information on the health status of individual animals or populations in direct comparison to expected values or reference intervals developed using the same analysis methodology from a healthy reference population of the target species. Point‐of‐care analysers are increasingly used in the assessment of
RA Jelic   +4 more
wiley   +1 more source

The Diverse Roles of microRNAs at the Host–Virus Interface

open access: yesViruses, 2018
MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression at the post-transcriptional level. Through this activity, they are implicated in almost every cellular process investigated to date.
Annie Bernier, Selena M. Sagan
doaj   +1 more source

Human APOBEC3G suppresses homologous recombination and LIG4‐independent end joining in DNA double‐strand break repair

open access: yesThe FEBS Journal, EarlyView.
Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito   +6 more
wiley   +1 more source

Anti-viral activity of red microalgal polysaccharides against retroviruses

open access: yesCancer Cell International, 2002
Red microalgal polysaccharides significantly inhibited the production of retroviruses (murine leukemia virus- MuLV) and cell transformation by murine sarcoma virus(MuSV-124) in cell culture.
Huleihel Mahmoud M   +2 more
doaj   +1 more source

The H19/miR‐760/BST2 regulatory axis sustains breast cancer tumorigenesis and metastasis

open access: yesThe FEBS Journal, EarlyView.
H19 and BST2 promote breast cancer aggressiveness through their reciprocal coregulation by miR‐760. Since both transcripts are targeted by miR‐760, overexpression of one sequesters the microRNA and relieves repression of the other: H19 raises BST2 levels, and BST2 raises H19 levels.
Kekely Klouyovo   +8 more
wiley   +1 more source

Viroids-First—A Model for Life on Earth, Mars and Exoplanets

open access: yesGeosciences, 2019
The search for extraterrestrial life, recently fueled by the discovery of exoplanets, requires defined biosignatures. Current biomarkers include those of extremophilic organisms, typically archaea.
Karin Moelling, Felix Broecker
doaj   +1 more source

Multiple Sclerosis and Viruses: « Liaisons Dangereuses ». [PDF]

open access: yesRev Med Virol
ABSTRACT Multiple sclerosis (MS) is a complex, multifactorial neurodegenerative disease with an aetiology that is still partially elusive. Several risk factors are associated with MS development including genetic predisposition and various environmental stressors; however, recently, viral infections have gained significant attention as a crucial ...
Plavina S   +11 more
europepmc   +2 more sources

Combining TAG‐72CAR with anti‐MUC16CAR improves the potency of ovarian cancer treatment

open access: yesThe FEBS Journal, EarlyView.
Tz‐KBBCAR, a combinatorial CAR targeting MUC16 and TAG‐72, enhances the precision of ovarian cancer immunotherapy. By requiring both tumour antigens for full activation, Tz‐KBBCAR was designed to eliminate MUC16+/TAG‐72+ cancer cells, while sparing MUC16+/TAG‐72‐ healthy cells.
Alicia Villatoro   +13 more
wiley   +1 more source

Revisiting Plus-Strand DNA Synthesis in Retroviruses and Long Terminal Repeat Retrotransposons: Dynamics of Enzyme: Substrate Interactions

open access: yesViruses, 2009
Although polypurine tract (PPT)-primed initiation of plus-strand DNA synthesis in retroviruses and LTR-containing retrotransposons can be accurately duplicated, the molecular details underlying this concerted series of events remain largely unknown ...
Stuart F. J. Le Grice   +2 more
doaj   +1 more source

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