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Adults with celiac disease exhibit overexpression of endogenous retroviruses, TRIM28, and SETDB1 despite gluten-free diet. [PDF]

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Packaging shRNA Retroviruses

Cold Spring Harbor Protocols, 2013
To silence a mammalian gene by RNAi using an encoded trigger, a short-hairpin RNA (shRNA) is integrated into the host cell genome as a stable transgene. Target cells are infected with viral plasmid containing shRNA inserted into the vector backbone. Before infection, the plasmid is transfected into a packaging cell line, which provides the trans-acting
Kenneth, Chang   +3 more
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Xenografts and Retroviruses

Science, 1999
Pigs have been suggested as a source of tissues and organs for transplantation. However, as [Weiss][1] discusses in a Perspective, one of the main safety concerns has been that porcine retroviruses present in pig tissue might take up residence in the human host after transplantation, resulting in the emergence of a new infectious disease.
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RETROVIRUSES AND ONCOGENES

Rheumatology, 1989
Rheumatoid arthritis (RA) is probably an auto-immune disorder incited by an infectious insult or primary disorder of the immune system. A viral aetiology is particularly attractive, as not only do we have documented virally associated arthritides in humans, e.g. rubella, Epstein-Barr virus and parvovirus, but also a member of the lentivirus subgroup of
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Pathogenic Human Retroviruses

New England Journal of Medicine, 1988
In the report by Minamoto et al. in this issue of the Journal, we have a striking reminder of the importance of pathogenic retroviruses, a special class of molecular pirates, both to individuals an...
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Retroviruses and psoriasis

Current Opinion in Infectious Diseases, 2000
Psoriasis occurs with at least undiminished frequency in HIV infected individuals. The behaviour of psoriasis in HIV disease is of interest, both in terms of pathogenesis and therapy, because of the background of profound immunodysregulation. It is paradoxical that, while drugs that target T lymphocytes are effective in psoriasis, the condition should ...
openaire   +2 more sources

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